• 2183 Citations
  • 17 h-Index
19992020

Research output per year

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Research Output

2020

A JUN N-terminal kinase inhibitor induces ectodomain shedding of the cancer-associated membrane protease Prss14/epithin via protein kinase CβII

Yoon, J., Cho, Y., Kim, K. Y., Yoon, M. J., Lee, H. S., Jeon, S. D., Cho, Y., Kim, C. & Kim, M. G., 2020 May 15, In : Journal of Biological Chemistry. 295, 20, p. 7168-7177 10 p.

Research output: Contribution to journalArticle

Open Access
Open Access

Intramembrane proteolysis of an extracellular serine protease, epithin/PRSS14, enables its intracellular nuclear function

Cho, Y., Kim, S. B., Kim, J., Pham, A. V. Q., Yoon, M. J., Park, J. H., Hwang, K. T., Park, D., Cho, Y., Kim, M. G. & Kim, C., 2020 Jun 3, In : BMC biology. 18, 1, 60.

Research output: Contribution to journalArticle

Open Access

Selection and identification of a novel bone-targeting peptide for biomedical imaging of bone

Bang, J., Park, H., Yoo, J., Lee, D., Choi, W. I., Lee, J. H., Lee, Y. R., Kim, C., Koo, H. & Kim, S., 2020 Dec 1, In : Scientific reports. 10, 1, 10576.

Research output: Contribution to journalArticle

Open Access

Topological Adaptation of Transmembrane Domains to the Force-Modulated Lipid Bilayer Is a Basis of Sensing Mechanical Force

Kim, J., Lee, J., Jang, J., Ye, F., Hong, S. J., Petrich, B. G., Ulmer, T. S. & Kim, C., 2020 May 4, In : Current Biology. 30, 9, p. 1614-1625.e5

Research output: Contribution to journalArticle

4 Citations (Scopus)
2019

Targeting metastatic breast cancer with peptide epitopes derived from autocatalytic loop of Prss14/ST14 membrane serine protease and with monoclonal antibodies

Kim, K. Y., Yoon, M., Cho, Y., Lee, K. H., Park, S., Lee, S. R., Choi, S. Y., Lee, D., Yang, C., Cho, E. H., Jeon, S. D., Kim, S. H., Kim, C. & Kim, M. G., 2019 Aug 19, In : Journal of Experimental and Clinical Cancer Research. 38, 1, 363.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

Cellular machinery for sensing mechanical force

Lim, C. G., Jang, J. & Kim, C., 2018 Dec 1, In : BMB Reports. 51, 12, p. 623-629 7 p.

Research output: Contribution to journalShort survey

Open Access
10 Citations (Scopus)

Membrane Anchoring of α-Helical Proteins: Role of Tryptophan

Situ, A. J., Kang, S. M., Frey, B. B., An, W., Kim, C. & Ulmer, T. S., 2018 Jan 25, In : Journal of Physical Chemistry B. 122, 3, p. 1185-1194 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2017

Disruption of TACE-filamin interaction can inhibit TACE-mediated ectodomain shedding

Cho, Y., Park, D. & Kim, C., 2017 Aug 26, In : Biochemical and Biophysical Research Communications. 490, 3, p. 997-1003 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Epigallocatechin gallate has pleiotropic effects on transmembrane signaling by altering the embedding of transmembrane domains

Ye, F., Yang, C., Kim, J., MacNevin, C. J., Hahn, K. M., Park, D., Ginsberg, M. H. & Kim, C., 2017 Jun 16, In : Journal of Biological Chemistry. 292, 24, p. 9858-9864 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Identification of indothiazinone as a natural antiplatelet agent

Yang, C., Kwon, S., Kim, S. J., Jeong, M., Park, J-Y., Park, D., Hong, S. J., Jung, J. W. & Kim, C., 2017, (Accepted/In press) In : Chemical Biology and Drug Design.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Talin modulation by a synthetic N-acylurea derivative reduces angiogenesis in human endothelial cells

Lim, I. R., Joo, H. J., Jeong, M., Kim, J. H., Choi, S. C., Kim, C., Jung, J. W. & Hong, S. J., 2017 Jan 22, In : International Journal of Molecular Sciences. 18, 1, 221.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2016

Amelioration of sepsis by TIE2 activation-induced vascular protection

Han, S., Lee, S. J., Kim, K. E., Lee, H. S., Oh, N., Park, I., Ko, E., Oh, S. J., Lee, Y. S., Kim, D., Lee, S., Lee, D. H., Lee, K. H., Chae, S. Y., Lee, J. H., Kim, S. J., Kim, H. C., Kim, S., Kim, S. H., Kim, C. & 9 others, Nakaoka, Y., He, Y., Augustin, H. G., Hu, J., Song, P. H., Kim, Y. I., Kim, P., Kim, I. & Koh, G. Y., 2016 Apr 20, In : Science Translational Medicine. 8, 335

Research output: Contribution to journalArticle

78 Citations (Scopus)

Antibody neutralization of cell-surface gC1qR/HABP1/SF2-p32 prevents lamellipodia formation and tumorigenesis

Kim, B. C., Hwang, H. J., An, H. T., Lee, H., Park, J. S., Hong, J., Ko, J. S., Kim, C., Lee, J. S. & Ko, Y-G., 2016, In : Oncotarget. 7, 31, p. 49972-49985 14 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Calmodulin Mediates Ca2+-Dependent Inhibition of Tie2 Signaling and Acts as a Developmental Brake during Embryonic Angiogenesis

Yang, C., Ohk, J., Lee, J. Y., Kim, E. J., Kim, J., Han, S., Park, D., Jung, H. & Kim, C., 2016 Jul 1, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 36, 7, p. 1406-1416 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Impact of suppression of tumorigenicity 14 (ST14)/serine protease 14 (prss14) expression analysis on the prognosis and management of estrogen receptor negative breast cancer

Kim, S., Yang, J. W., Kim, C. & Kim, M. G., 2016 Jun 7, In : Oncotarget. 7, 23, p. 34643-34663 21 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The Rap1-RIAM-talin axis of integrin activation and blood cell function

Lagarrigue, F., Kim, C. & Ginsberg, M. H., 2016 Jul 28, In : Blood. 128, 4, p. 479-487 9 p.

Research output: Contribution to journalReview article

41 Citations (Scopus)

Vimentin filament controls integrin α5β1-mediated cell adhesion by binding to integrin through its Ser38 residue

Kim, J., Jang, J., Yang, C., Kim, E. J., Jung, H. & Kim, C., 2016 Oct 1, In : FEBS Letters. 590, 20, p. 3517-3525 9 p.

Research output: Contribution to journalLetter

4 Citations (Scopus)

Vimentin filaments regulate integrin-ligand interactions by binding to the cytoplasmic tail of integrin β3

Kim, J., Yang, C., Kim, E. J., Jang, J., Kim, S. J., Kang, S. M., Kim, M. G., Jung, H., Park, D. & Kim, C., 2016 May 15, In : Journal of Cell Science. 129, 10, p. 2030-2042 13 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2014

Gln-362 of angiopoietin-2 mediates migration of tumor and endothelial cells through association with α5β1 integrin

Lee, H. S., Oh, S. J., Lee, K. H., Lee, Y. S., Ko, E., Kim, K. E., Kim, H. C., Kim, S., Song, P. H., Kim, Y. I., Kim, C. & Han, S., 2014 Nov 7, In : Journal of Biological Chemistry. 289, 45, p. 31330-31340 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Integrin αIIb tail distal of GFFKR participates in inside-out αIIbβ3 activation

Li, A., Guo, Q., Kim, C., Hu, W. & Ye, F., 2014 Jan 1, In : Journal of Thrombosis and Haemostasis. 12, 7, p. 1145-1155 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Intermolecular transmembrane domain interactions activate integrin αIIbβ3

Ye, F., Kim, S. J. & Kim, C., 2014 Jun 27, In : Journal of Biological Chemistry. 289, 26, p. 18507-18513 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Shedding of epithin/PRSS14 is induced by TGF-β and mediated by tumor necrosis factor-α converting enzyme

Lee, H. S., Park, B. M., Cho, Y., Kim, S., Kim, C., Kim, M. G. & Park, D., 2014 Oct 3, In : Biochemical and Biophysical Research Communications. 452, 4, p. 1084-1090 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2013
7 Citations (Scopus)

Erratum: Basic amino-acid side chains regulate transmembrane integrin signalling (Nature (2012) 481 (209-213) DOI: 10.1038/nature10697)

Kim, C., Schmidt, T., Cho, E. G., Ye, F., Ulmer, T. S. & Ginsberg, M. H., 2013 May 30, In : Nature. 497, 7451, 1 p.

Research output: Contribution to journalComment/debate

The nucleus of endothelial cell as a sensor of blood flow direction

Tkachenko, E., Gutierrez, E., Saikin, S. K., Fogelstrand, P., Kim, C., Groisman, A. & Ginsberg, M. H., 2013 Oct 15, In : Biology Open. 2, 10, p. 1007-1012 6 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
2012

Basic amino-acid side chains regulate transmembrane integrin signalling

Kim, C., Schmidt, T., Cho, E. G., Ye, F., Ulmer, T. S. & Ginsberg, M. H., 2012 Jan 12, In : Nature. 481, 7380, p. 209-214 6 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Reconstruction of integrin activation

Ye, F., Kim, C. & Ginsberg, M. H., 2012 Jan 5, In : Blood. 119, 1, p. 26-33 8 p.

Research output: Contribution to journalReview article

60 Citations (Scopus)

Talin activates integrins by altering the topology of the β transmembrane domain

Kim, C., Ye, F., Hu, X. & Ginsberg, M. H., 2012 May, In : Journal of Cell Biology. 197, 5, p. 605-611 7 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)
2011

Epithin/PRSS14 proteolytically regulates angiopoietin receptor Tie2 during transendothelial migration

Kim, C., Lee, H. S., Lee, D., Lee, S. D., Cho, E. G., Yang, S. J., Kim, S. B., Park, D. & Kim, M. G., 2011 Jan 27, In : Blood. 117, 4, p. 1415-1424 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Molecular mechanism of inside-out integrin regulation

Ye, F., Kim, C. & Ginsberg, M. H., 2011 Jul, In : Journal of Thrombosis and Haemostasis. 9, 1 S, p. 20-25 6 p.

Research output: Contribution to journalReview article

61 Citations (Scopus)

Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells

Tkachenko, E., Sabouri-Ghomi, M., Pertz, O., Kim, C., Gutierrez, E., MacHacek, M., Groisman, A., Danuser, G. & Ginsberg, M. H., 2011 Jun, In : Nature Cell Biology. 13, 6, p. 660-668 9 p.

Research output: Contribution to journalArticle

97 Citations (Scopus)

Regulation of integrin activation

Kim, C., Ye, F. & Ginsberg, M. H., 2011, In : Annual Review of Cell and Developmental Biology. 27, p. 321-345 25 p.

Research output: Contribution to journalArticle

247 Citations (Scopus)
2010

Epithin, a target of transforming growth factor-β signaling, mediates epithelial-mesenchymal transition

Lee, H. S., Kim, C., Kim, S. B., Kim, M. G. & Park, D., 2010 May 14, In : Biochemical and biophysical research communications. 395, 4, p. 553-559 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Soluble epithin/PRSS14 secreted from cancer cells contains active angiogenic potential

Kim, S. B., Lee, D., Jeong, J. W., Kim, C., Park, D. & Kim, M. G., 2010 Jun, In : Molecules and cells. 29, 6, p. 617-623 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

The final steps of integrin activation: The end game

Shattil, S. J., Kim, C. & Ginsberg, M. H., 2010 Apr, In : Nature Reviews Molecular Cell Biology. 11, 4, p. 288-300 13 p.

Research output: Contribution to journalReview article

591 Citations (Scopus)
2009

Interactions of platelet integrin αIIb and β3 transmembrane domains in mammalian cell membranes and their role in integrin activation

Kim, C., Lau, T. L., Ulmer, T. S. & Ginsberg, M. H., 2009, In : Blood. 113, 19, p. 4747-4753 7 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

The structure of an integrin/talin complex reveals the basis of inside-out signal transduction

Anthis, N. J., Wegener, K. L., Ye, F., Kim, C., Goult, B. T., Lowe, E. D., Vakonakis, I., Bate, N., Critchley, D. R., Ginsberg, M. H. & Campbell, I. D., 2009 Nov, In : EMBO Journal. 28, 22, p. 3623-3632 10 p.

Research output: Contribution to journalArticle

209 Citations (Scopus)

The structure of the integrin αiIbΒ3 transmembrane complex explains integrin transmembrane signalling

Lau, T. L., Kim, C., Ginsberg, M. H. & Ulmer, T. S., 2009 May 6, In : EMBO Journal. 28, 9, p. 1351-1361 11 p.

Research output: Contribution to journalArticle

239 Citations (Scopus)
2007

CD98hc (SLC3A2) interaction with the integrin β subunit cytoplasmic domain mediates adhesive signaling

Prager, G. W., Féral, C. C., Kim, C., Han, J. & Ginsberg, M. H., 2007 Aug 17, In : Journal of Biological Chemistry. 282, 33, p. 24477-24484 8 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
2005

Filamin is essential for shedding of the transmembrane serine protease, epithin

Kim, C., Cho, Y., Kang, C. H., Kim, M. G., Lee, H. S., Cho, E. G. & Park, D., 2005 Nov, In : EMBO Reports. 6, 11, p. 1045-1051 7 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
2001

N-terminal Processing Is Essential for Release of Epithin, a Mouse Type II Membrane Serine Protease

Cho, E. G., Kim, M. G., Kim, C., Kim, S. R., Seong, I. S., Chung, C., Schwartz, R. H. & Park, D., 2001 Nov 30, In : Journal of Biological Chemistry. 276, 48, p. 44581-44589 9 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)
1999

Promotion of skeletal muscle differentiation by K252a with tyrosine phosphorylation of focal adhesion: A possible involvement of small GTPase Rho

Lee, K. H., Lee, S. H., Kim, D., Rhee, S., Kim, C., Chung, C. H., Kwon, H. & Kang, M. S., 1999 Nov 1, In : Experimental Cell Research. 252, 2, p. 401-415 15 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)