• 3304 Citations
  • 31 h-Index
1993 …2020

Research output per year

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Research Output

2020

Brain-specific chemokine FAM19A5 induces hypothalamic inflammation

Kang, D., Kim, H. R., Kim, K. K., Kim, D. H., Jeong, B., Jin, S., Park, J. W., Seong, J. Y. & Lee, B. J., 2020 Mar 19, In : Biochemical and biophysical research communications. 523, 4, p. 829-834 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Exploring the molecular structures that confer ligand selectivity for galanin type II and III receptors

Lee, Y. N., Reyes-Alcaraz, A., Yun, S., Lee, C. S., Hwang, J. I. & Seong, J. Y., 2020 Jan 1, In : PloS one. 15, 3, e0230872.

Research output: Contribution to journalArticle

Open Access

Serum FAM19A5 levels: A novel biomarker for neuroinflammation and neurodegeneration in major depressive disorder

Han, K. M., Tae, W. S., Kim, A., Kang, Y., Kang, W., Kang, J., Kim, Y. K., Kim, B., Seong, J. Y. & Ham, B. J., 2020 Jul, In : Brain, Behavior, and Immunity. 87, p. 852-859 8 p.

Research output: Contribution to journalArticle

The unique expression profile of FAM19A1 in the mouse brain and its association with hyperactivity, long-term memory and fear acquisition

Yong, H. J., Ha, N., Cho, E. B., Yun, S., Kim, H., Hwang, J. I. & Seong, J. Y., 2020 Dec 1, In : Scientific reports. 10, 1, 3969.

Research output: Contribution to journalArticle

Open Access
2019

Distribution and neuronal circuit of spexin 1/2 neurons in the zebrafish CNS

Kim, E., Jeong, I., Chung, A. Y., Kim, S., Kwon, S. H., Seong, J. Y. & Park, H. C., 2019 Dec 1, In : Scientific Reports. 9, 1, 5025.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

FAM19A5 expression during embryogenesis and in the adult traumatic brain of FAM19A5-LacZ Knock-in mice

Shahapal, A., Cho, E. B., Yong, H. J., Jeong, I., Kwak, H., Lee, J. K., Kim, W., Kim, B., Park, H. C., Lee, W. S., Kim, H., Hwang, J. I. & Seong, J. Y., 2019 Jan 1, In : Frontiers in Neuroscience. 13, AUG, 917.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Monitoring gpcr-β-arrestin1/2 interactions in real time living systems to accelerate drug discovery

Reyes-Alcaraz, A., Lee, Y. N., Yun, S., Hwang, J-I. & Seong, J. Y., 2019 Jun 1, In : Journal of Visualized Experiments. 2019, 148, e59994.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Overexpression of Spexin 1 in the Dorsal Habenula Reduces Anxiety in Zebrafish

Jeong, I., Kim, E., Seong, J. Y. & Park, H. C., 2019 Jan 1, In : Frontiers in neural circuits. 13, 1 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Serum FAM19A5 in neuromyelitis optica spectrum disorders: Can it be a new biomarker representing clinical status?

Lee, H. L., Seok, H. Y., Ryu, H. W., Cho, E. B., Kim, B. C., Kim, B. J., Min, J. H., Seok, J. M., Shin, H. Y., Kang, S. Y., Kwon, O. H., Lee, S. S., Oh, J., Sohn, E. H., Huh, S. Y., Cho, J. Y., Seong, J. Y. & Kim, B. J., 2019 Jan 1, (Accepted/In press) In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticle

1 Citation (Scopus)

SP-8356, a (1S)-(–)-verbenone derivative, exerts in vitro and in vivo anti-breast cancer effects by inhibiting NF-κB signaling

Mander, S., Kim, D. H., Thi Nguyen, H., Yong, H. J., Pahk, K., Kim, E. Y., Lee, K., Seong, J. Y., Kim, W-K. & Hwang, J-I., 2019 Dec 1, In : Scientific Reports. 9, 1, 6595.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Spexin-based galanin receptor type 2 agonist for comorbid mood disorders and abnormal body weight

Yun, S., Reyes-Alcaraz, A., Lee, Y. N., Yong, H. J., Choi, J., Ham, B. J., Sohn, J. W., Kim, D. H., Son, G. H., Kim, H., Kwon, S. G., Kim, D. S., Kim, B. C., Hwang, J. I. & Seong, J. Y., 2019 Jan 1, In : Frontiers in Neuroscience. 13, APR, 391.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)
2018

Conformational signatures in β-arrestin2 reveal natural biased agonism at a G-protein-coupled receptor

Reyes-Alcaraz, A., Lee, Y. N., Yun, S., Hwang, J-I. & Seong, J. Y., 2018 Dec 1, In : Communications Biology. 1, 1, 128.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

mRNA expression and metabolic regulation of npy and agrp1/2 in the zebrafish brain

Jeong, I., Kim, E., Kim, S., Kim, H. K., Lee, D. W., Seong, J. Y. & Park, H. C., 2018 Mar 6, In : Neuroscience Letters. 668, p. 73-79 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Replacement of the C-terminal Trp-cage of exendin-4 with a fatty acid improves therapeutic utility

Lee, J. G., Ryu, J. H., Kim, S. M., Park, M. Y., Kim, S. H., Shin, Y. G., Sohn, J. W., Kim, H. H., Park, Z. Y., Seong, J. Y. & Kim, J. I., 2018 May 1, In : Biochemical Pharmacology. 151, p. 59-68 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Spexin-based GALR2 agonists and use thereof

Seong, J. Y., Kim, D-H., Son, G. H. & Hwang, J-I., 2018 Jul 30, Patent No. 10-1885238

Research output: Patent

2017
3 Citations (Scopus)

FAM19A5, a brain-specific chemokine, inhibits RANKL-induced osteoclast formation through formyl peptide receptor 2

Park, M. Y., Kim, H. S., Lee, M., Park, B., Lee, H. Y., Cho, E. B., Seong, J. Y. & Bae, Y. S., 2017 Dec 1, In : Scientific Reports. 7, 1, 15575.

Research output: Contribution to journalArticle

12 Citations (Scopus)

GABBR2 mutations determine phenotype in rett syndrome and epileptic encephalopathy

Yoo, Y., Jung, J., Lee, Y. N., Lee, Y., Cho, H., Na, E., Hong, J. Y., Kim, E., Lee, J. S., Lee, J. S., Hong, C., Park, S. Y., Wie, J., Miller, K., Shur, N., Clow, C., Ebel, R. S., DeBrosse, S. D., Henderson, L. B., Willaert, R. & 15 others, Castaldi, C., Tikhonova, I., Bilgüvar, K., Mane, S., Kim, K. J., Hwang, Y. S., Lee, S. G., So, I., Lim, B. C., Choi, H. J., Seong, J. Y., Shin, Y. B., Jung, H., Chae, J. H. & Choi, M., 2017 Sep 1, In : Annals of Neurology. 82, 3, p. 466-478 13 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Nafamostat mesilate negatively regulates the metastasis of triple-negative breast cancer cells

Mander, S., You, D. J., Park, S., Kim, D. H., Yong, H. J., Kim, D-S., Ahn, C., Kim, Y. H., Seong, J. Y. & Hwang, J-I., 2017 Dec 1, (Accepted/In press) In : Archives of Pharmacal Research. p. 1-14 14 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2016

Characterization of functional domains in NME1L regulation of NF-κB signaling

You, D. J., Park, C. R., Mander, S., Ahn, C., Seong, J. Y. & Hwang, J-I., 2016 May 1, In : Molecules and Cells. 39, 5, p. 403-409 7 p.

Research output: Contribution to journalArticle

Development of spexin-based human galanin receptor type II-specific agonists with increased stability in serum and anxiolytic effect in mice

Reyes-Alcaraz, A., Lee, Y. N., Son, G. H., Kim, N. H., Kim, D. K., Yun, S., Kim, D-H., Hwang, J-I. & Seong, J. Y., 2016 Feb 24, In : Scientific Reports. 6, 21453.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Distribution of galanin receptor 2b neurons and interaction with galanin in the zebrafish central nervous system

Kim, E., Jeong, I., Kim, S., Kim, H. K., Lee, D. W., Kim, B., Seong, J. Y., Bae, Y. K., Ryu, J. H. & Park, H. C., 2016 Aug 15, In : Neuroscience Letters. 628, p. 153-160 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

NME1L Negatively Regulates IGF1-Dependent Proliferation of Breast Cancer Cells

You, D. J., Mander, S., Park, C. R., Koo, O., Lee, C., Oh, S. H., Ahn, C., Seong, J. Y. & Hwang, J-I., 2016 Jun 1, In : Journal of Cellular Biochemistry. 117, 6, p. 1454-1463 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The accessory proteins REEP5 and REEP6 refine CXCR1-mediated cellular responses and lung cancer progression

Park, C. R., You, D. J., Park, S., Mander, S., Jang, D. E., Yeom, S. C., Oh, S. H., Ahn, C., Lee, S. H., Seong, J. Y. & Hwang, J-I., 2016 Dec 14, In : Scientific Reports. 6, 39041.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2015

Dimer of arfaptin 2 regulates NF-κB signaling by interacting with IKKβ/NEMO and inhibiting IKKβ kinase activity

You, D. J., Park, C. R., Furlong, M., Koo, O., Lee, C., Ahn, C., Seong, J. Y. & Hwang, J-I., 2015 Nov 1, In : Cellular Signalling. 27, 11, p. 2173-2181 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Histidine7.36(305) in the conserved peptide receptor activation domain of the gonadotropin releasing hormone receptor couples peptide binding and receptor activation

Mayevu, N. M. I., Choe, H., Abagyan, R., Seong, J. Y., Millar, R. P., Katz, A. A. & Flanagan, C. A., 2015 Feb 5, In : Molecular and Cellular Endocrinology. 402, p. 95-106 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Ligand binding pocket formed by evolutionarily conserved residues in the glucagon-like peptide-1 (GLP-1) receptor core domain

Moon, M. J., Lee, Y. N., Park, S., Reyes-Alcaraz, A., Hwang, J-I., Millar, R. P., Choe, H. & Seong, J. Y., 2015 Feb 27, In : Journal of Biological Chemistry. 290, 9, p. 5696-5706 11 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Prevertebrate local gene duplication facilitated expansion of the neuropeptide GPCR superfamily

Yun, S., Furlong, M., Sim, M., Cho, M., Park, S., Cho, E. B., Reyes-Alcaraz, A., Hwang, J-I., Kim, J. & Seong, J. Y., 2015 Nov 1, In : Molecular Biology and Evolution. 32, 11, p. 2803-2817 15 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Soluble overexpression and purification of bioactive human CCL2 in E. coli by maltose-binding protein

Vu, T. T. T., Koo, B. K., Song, J. A., Chong, S. H., Park, C. R., Nguyen, M. T., Jeong, B., Ryu, H. B., Seong, J. Y., Jang, Y. J., Robinson, R. C. & Choe, H., 2015, In : Molecular Biology Reports. 42, 3, p. 651-663 13 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Use of spexin as ligand of galanin receptor type 3

Seong, J. Y. & Hwang, J-I., 2015 Apr 16, Patent No. 10-1514440

Research output: Patent

2014

A novel long-acting glucagon-like peptide-1 agonist with improved efficacy in insulin secretion and β-cell growth

Kim, H. Y., Hwang, J-I., Moon, M. J. & Seong, J. Y., 2014, In : Endocrinology and Metabolism. 29, 3, p. 320-327 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Apoptotic death of prostate cancer cells by a gonadotropin-releasing hormone-II antagonist

Park, S., Han, J. M., Cheon, J., Hwang, J-I. & Seong, J. Y., 2014 Jun 13, In : PLoS One. 9, 6, e99723.

Research output: Contribution to journalArticle

9 Citations (Scopus)

A splicing variant of NME1 negatively regulates NF-κB signaling and inhibits cancer metastasis by interacting with IKKβ

You, D. J., Park, C. R., Lee, H. B., Moon, M. J., Kang, J. H., Lee, C., Oh, S. H., Ahn, C., Seong, J. Y. & Hwang, J-I., 2014 Jun 20, In : Journal of Biological Chemistry. 289, 25, p. 17709-17720 12 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III

Kim, D. K., Yun, S., Son, G. H., Hwang, J. I., Park, C. R., Kim, J. I., Kim, K., Vaudry, H. & Seong, J. Y., 2014 May, In : Endocrinology. 155, 5, p. 1864-1873 10 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Does kisspeptin belong to the proposed RF-amide peptide family?

Yun, S., Kim, D. K., Furlong, M., Hwang, J-I., Vaudry, H. & Seong, J. Y., 2014, In : Frontiers in Endocrinology. 5, AUG, 134.

Research output: Contribution to journalShort survey

17 Citations (Scopus)

Identification of a novel insect neuropeptide, CNMa and its receptor

Jung, S. H., Lee, J. H., Chae, H. S., Seong, J. Y., Park, Y., Park, Z. Y. & Kim, Y. J., 2014 Jul 5, In : FEBS Letters. 588, 12, p. 2037-2041 5 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Local duplication of gonadotropin-releasing hormone (GnRH) receptor before two rounds of whole genome duplication and origin of the mammalian GnRH receptor

Sefideh, F. A., Moon, M. J., Yun, S., Hong, S. I., Hwang, J. I. & Seong, J. Y., 2014 Feb 3, In : PloS one. 9, 2, e87901.

Research output: Contribution to journalArticle

15 Citations (Scopus)

MOlecular evolution of GPCRs: GLP1/GLP1 receptors

Hwang, J. I., Yun, S., Moon, M. J., Park, C. R. & Seong, J. Y., 2014 Mar 5, In : Journal of Molecular Endocrinology. 52, 3, p. T15-T27

Research output: Contribution to journalReview article

15 Citations (Scopus)

Neuropeptide GPCRs in neuroendocrinology

Vaudry, H. & Seong, J. Y., 2014, In : Frontiers in Endocrinology. 5, APR, Article 41.

Research output: Contribution to journalEditorial

5 Citations (Scopus)

Pharmaceutical use of FAM19A5 involved in gliogenesis

Seong, J. Y., Sun, W. & Hwang, J-I., 2014 Jun 3, Patent No. 10-1406393

Research output: Patent

2013

A Novel Glucagon-Related Peptide (GCRP) and Its Receptor GCRPR Account for Coevolution of Their Family Members in Vertebrates

Park, C. R., Moon, M. J., Park, S., Kim, D. K., Cho, E. B., Millar, R. P., Hwang, J. I. & Seong, J. Y., 2013 Jun 11, In : PloS one. 8, 6, e65420.

Research output: Contribution to journalArticle

21 Citations (Scopus)

CXCL14 enhances proliferation and migration of NCI-H460 human lung cancer cells overexpressing the glycoproteins containing heparan sulfate or sialic acid

Park, C. R., You, D. J., Kim, D. K., Moon, M. J., Lee, C., Oh, S. H., Ahn, C., Seong, J. Y. & Hwang, J. I., 2013 May, In : Journal of cellular biochemistry. 114, 5, p. 1084-1096 13 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Expansion of secretin-like G protein-coupled receptors and their peptide ligands via local duplications before and after two rounds of whole-genome duplication

Hwang, J. I., Moon, M. J., Park, S., Kim, D. K., Cho, E. B., Ha, N., Son, G. H., Kim, K., Vaudry, H. & Seong, J. Y., 2013 May, In : Molecular Biology and Evolution. 30, 5, p. 1119-1130 12 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Gonadotropin-releasing hormone stimulates the biosynthesis of pregnenolone sulfate and dehydroepiandrosterone sulfate in the hypothalamus

Burel, D., Li, J. H., Do-Rego, J. L., Wang, A. F., Luu-The, V., Pelletier, G., Tillet, Y., Taragnat, C., Kwon, H. B., Seong, J. Y. & Vaudry, H., 2013 Jun 1, In : Endocrinology. 154, 6, p. 2114-2128 15 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Natalisin, a tachykinin-like signaling system, regulates sexual activity and fecundity in insects

Jiang, H., Lkhagva, A., Daubnerová, I., Chae, H. S., Šimo, L., Jung, S. H., Yoon, Y. K., Lee, N. R., Seong, J. Y., Žitňan, D., Park, Y. & Kim, Y. J., 2013 Sep 10, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 37, p. E3526-E3534

Research output: Contribution to journalArticle

75 Citations (Scopus)

Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation

Choe, H. K., Kim, H. D., Park, S. H., Lee, H. W., Park, J. Y., Seong, J. Y., Lightman, S. L., Son, G. H. & Kim, K., 2013 Apr 2, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 14, p. 5677-5682 6 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)
2012

Anti-Cancer Activity of a Novel Small Molecule Compound That Simultaneously Activates p53 and Inhibits NF-κB Signaling

Hwang, S. G., Park, J., Park, J. Y., Park, C. H., Lee, K. H., Cho, J. W., Hwang, J. I. & Seong, J. Y., 2012 Sep 13, In : PloS one. 7, 9, e44259.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Evolutionarily conserved residues at glucagon-like peptide-1 (GLP-1) receptor core confer ligand-induced receptor activation

Moon, M. J., Kim, H. Y., Park, S., Kim, D. K., Cho, E. B., Park, C. R., You, D. J., Hwang, J. I., Kim, K., Choe, H. & Seong, J. Y., 2012 Feb 3, In : Journal of Biological Chemistry. 287, 6, p. 3873-3884 12 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Molecular coevolution of neuropeptides gonadotropin-releasing hormone and kisspeptin with their cognate G protein-coupled receptors

Kim, D. K., Cho, E. B., Moon, M. J., Park, S., Hwang, J. I., Rego, J. L. D., Vaudry, H. & Seong, J. Y., 2012, In : Frontiers in Neuroscience. JAN, 3.

Research output: Contribution to journalReview article

35 Citations (Scopus)