• 3325 Citations
  • 31 h-Index
1993 …2020

Research output per year

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Research Output

2012

Regulation of neurosteroid biosynthesis by neurotransmitters and neuropeptides

Rego, J. L. D., Seong, J. Y., Burel, D., Leprince, J., Vaudry, D., Luu-The, V., Tonon, M. C., Tsutsui, K., Pelletier, G. & Vaudry, H., 2012, In : Frontiers in Endocrinology. 3, JAN, Article 4.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Spatiotemporal expression and functional implication of CXCL14 in the developing mice cerebellum

Park, C. R., Kim, D. K., Cho, E. B., You, D. J., Do Rego, J. L., Vaudry, D., Sun, W., Kim, H., Seong, J. Y. & Hwang, J. I., 2012 Sep, In : Molecules and cells. 34, 3, p. 289-293 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Structural and molecular conservation of glucagon-like peptide-1 and its receptor confers selective ligand-receptor interaction

Moon, M. J., Park, S., Kim, D. K., Cho, E. B., Hwang, J. I., Vaudry, H. & Seong, J. Y., 2012, In : Frontiers in Endocrinology. 3, NOV, Article 141.

Research output: Contribution to journalReview article

14 Citations (Scopus)
2011

Class-C Sox transcription factors control GnRH gene expression via the intronic transcriptional enhancer

Kim, H. D., Choe, H. K., Chung, S., Kim, M., Seong, J. Y., Son, G. H. & Kim, K., 2011 Jul 1, In : Molecular Endocrinology. 25, 7, p. 1184-1196 13 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Insulin contributes to fine-tuning of the pancreatic beta-cell response to glucagon-like peptide-1

Moon, M. J., Kim, H. Y., Park, S., Kim, D. K., Cho, E. B., Hwang, J. I. & Seong, J. Y., 2011 Oct, In : Molecules and cells. 32, 4, p. 389-395 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Organization of two independent kisspeptin systems derived from evolutionary-ancient kiss genes in the brain of zebrafish

Servili, A., Le Page, Y., Leprince, J., Caraty, A., Escobar, S., Parhar, I. S., Seong, J. Y., Vaudry, H. & Kah, O., 2011 Apr, In : Endocrinology. 152, 4, p. 1527-1540 14 p.

Research output: Contribution to journalArticle

159 Citations (Scopus)

Regulatory roles of heterogeneous nuclear ribonucleoprotein M and Nova-1 protein in alternative splicing of dopamine D2 receptor pre-mRNA

Park, E., Iaccarino, C., Lee, J., Kwon, I., Baik, S. M., Kim, M., Seong, J. Y., Son, G. H., Borrelli, E. & Kim, K., 2011 Jul 15, In : Journal of Biological Chemistry. 286, 28, p. 25301-25308 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Revisiting the evolution of gonadotropin-releasing hormones and their receptors in vertebrates: Secrets hidden in genomes

Kim, D. K., Cho, E. B., Moon, M. J., Park, S., Hwang, J. I., Kah, O., Sower, S. A., Vaudry, H. & Seong, J. Y., 2011 Jan 1, In : General and Comparative Endocrinology. 170, 1, p. 68-78 11 p.

Research output: Contribution to journalReview article

73 Citations (Scopus)

Secretoneurin stimulates the production and release of luteinizing hormone in mouse lβt2 gonadotropin cells

Zhao, E., Mcneilly, J. R., McNeilly, A. S., Fischer-Colbrie, R., Basak, A., Seong, J. Y. & Trudeau, V. L., 2011 Aug, In : American Journal of Physiology - Endocrinology and Metabolism. 301, 2, p. E288-E297

Research output: Contribution to journalArticle

21 Citations (Scopus)
2010

Discovery and evolutionary history of gonadotrophin-inhibitory hormone and kisspeptin: New key neuropeptides controlling reproduction

Tsutsui, K., Bentley, G. E., Kriegsfeld, L. J., Osugi, T., Seong, J. Y. & Vaudry, H., 2010 Jul, In : Journal of Neuroendocrinology. 22, 7, p. 716-727 12 p.

Research output: Contribution to journalReview article

134 Citations (Scopus)

Intermolecular cross-talk between NTR1 and NTR2 neurotensin receptor promotes intracellular sequestration and functional inhibition of NTR1 receptors

Hwang, J. R., Baek, M. W., Sim, J., Choi, H. S., Han, J. M., Kim, Y. L., Hwang, J. I., Kwon, H. B., Beaudet, N., Sarret, P. & Seong, J. Y., 2010 Jan 1, In : Biochemical and biophysical research communications. 391, 1, p. 1007-1013 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Molecular coevolution of kisspeptins and their receptors from fish to mammals

Um, H. N., Han, J. M., Hwang, J. I., Hong, S. I., Vaudry, H. & Seong, J. Y., 2010 Jul, In : Annals of the New York Academy of Sciences. 1200, p. 67-74 8 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Regulation of IκB kinase by GβL through recruitment of the protein phosphatases

You, D. J., Kim, Y. L., Park, C. R., Kim, D. K., Yeom, J., Lee, C., Ahn, C., Seong, J. Y. & Hwang, J. I., 2010 Dec, In : Molecules and cells. 30, 6, p. 527-532 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Splicing variants of the orphan G-protein-coupled receptor GPR56 regulate the activity of transcription factors associated with tumorigenesis

Kim, J. E., Han, J. M., Park, C. R., Shin, K. J., Ahn, C., Seong, J. Y. & Hwang, J. I., 2010 Jan, In : Journal of Cancer Research and Clinical Oncology. 136, 1, p. 47-53 7 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Suppression of NF-κB signaling by KEAP1 regulation of IKKβ activity through autophagic degradation and inhibition of phosphorylation

Kim, J. E., You, D. J., Lee, C., Ahn, C., Seong, J. Y. & Hwang, J. I., 2010 Nov, In : Cellular Signalling. 22, 11, p. 1645-1654 10 p.

Research output: Contribution to journalArticle

113 Citations (Scopus)

Tyr1 and Ile7 of glucose-dependent insulinotropic polypeptide (GIP) confer differential ligand selectivity toward GIP and glucagon-like peptide-1 receptors

Moon, M. J., Kim, H. Y., Kim, S. G., Park, J., Choi, D. S., Hwang, J. I. & Seong, J. Y., 2010 Aug, In : Molecules and cells. 30, 2, p. 149-154 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2009

A gonadotropin-releasing hormone-II antagonist induces autophagy of prostate cancer cells

Dong-Ki, K., Ji, S. Y., Kaushik, M., Jong-Ik, H., Kyungjin, K., Dongseung, S., Younghee, A., Cheolji, L., Byeong-Cheol, K., Hyuk, B. K., Jun, C. & Jae, Y. S., 2009 Feb 1, In : Cancer Research. 69, 3, p. 923-931 9 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Lysophosphatidic acid signaling through LPA receptor subtype 1 induces colony scattering of gastrointestinal cancer cells

Shin, K. J., Kim, Y. L., Lee, S., Kim, D. K., Ahn, C., Chung, J., Seong, J. Y. & Hwang, J. I., 2009 Jan, In : Journal of Cancer Research and Clinical Oncology. 135, 1, p. 45-52 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Molecular cloning of the bullfrog kisspeptin receptor GPR54 with high sensitivity to Xenopus kisspeptin

Moon, J. S., Lee, Y. R., Oh, D. Y., Hwang, J. I., Lee, J. Y., Kim, J. I., Vaudry, H., Kwon, H. B. & Seong, J. Y., 2009 Jan, In : Peptides. 30, 1, p. 171-179 9 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Molecular evolution of multiple forms of kisspeptins and GPR54 receptors in vertebrates

Yeo, R. L., Tsunekawa, K., Mi, J. M., Haet, N. U., Hwang, J. I., Osugi, T., Otaki, N., Sunakawa, Y., Kim, K., Vaudry, H., Hyuk, B. K., Seong, J. Y. & Tsutsui, K., 2009 Jun, In : Endocrinology. 150, 6, p. 2837-2846 10 p.

Research output: Contribution to journalArticle

172 Citations (Scopus)

Molecular interaction between kisspeptin decapeptide analogs and a lipid membrane

Lee, J. Y., Moon, J. S., Eu, Y. J., Lee, C. W., Yang, S. T., Lee, S. K., Jung, H. H., Kim, H. H., Rhim, H., Seong, J. Y. & Kim, J. I., 2009 May 15, In : Archives of Biochemistry and Biophysics. 485, 2, p. 109-114 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Neurosteroid biosynthesis: Enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides

Do Rego, J. L., Seong, J. Y., Burel, D., Leprince, J., Luu-The, V., Tsutsui, K., Tonon, M. C., Pelletier, G. & Vaudry, H., 2009 Aug, In : Frontiers in Neuroendocrinology. 30, 3, p. 259-301 43 p.

Research output: Contribution to journalReview article

237 Citations (Scopus)

Nova-1 mediates glucocorticoid-induced inhibition of Pre-mRNA splicing of gonadotropin-releasing hormone transcripts

Park, E., Lee, M. S., Baik, S. M., Cho, E. B., Son, G. H., Seong, J. Y., Lee, K. H. & Kim, K., 2009 May 8, In : Journal of Biological Chemistry. 284, 19, p. 12792-12800 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Phylogenetic history, pharmacological features, and signal transduction of neurotensin receptors in vertebrates

Hwang, J. I., Kim, D. K., Kwon, H. B., Vaudry, H. & Seong, J. Y., 2009 Apr, Trends in Comparative Endocrinology and Neurobiology. Blackwell Publishing Inc., p. 169-178 10 p. (Annals of the New York Academy of Sciences; vol. 1163).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

12 Citations (Scopus)

Steroid biosynthesis within the frog brain: A model of neuroendocrine regulation

Do Rego, J. L., Seong, J. Y., Burel, D., Luu-The, V., Larhammar, D., Tsutsui, K., Pelletier, G., Tonon, M. C. & Vaudry, H., 2009 Apr, Trends in Comparative Endocrinology and Neurobiology. Blackwell Publishing Inc., p. 83-92 10 p. (Annals of the New York Academy of Sciences; vol. 1163).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

17 Citations (Scopus)
2008
5 Citations (Scopus)

GβL regulates TNFα-induced NF-k{cyrillic}B signaling by directly inhibiting the activation of Ik{cyrillic}B kinase

Kim, Y. L., Kim, J. E., Shin, K. J., Lee, S., Ahn, C., Chung, J., Kim, D. H., Seong, J. Y. & Hwang, J. I., 2008 Nov, In : Cellular Signalling. 20, 11, p. 2127-2133 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92

Oh, D. Y., Jung, M. Y., Mi, J. M., Jong-Ik, H., Han, C., Ju, Y. L., Jae, I. K., Sunoh, K., Hyewhon, R., David, K. O. D., Michael, J. W., Heung, S. N., Min, G. L., Hyuk, B. K., Kyungjin, K. & Jae, Y. S., 2008 Jul 25, In : Journal of Biological Chemistry. 283, 30, p. 21054-21064 11 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)

Involvement of amino acids flanking Glu7.32 of the Gonadotropin-releasing hormone receptor in the selectivity of antagonists

Wang, C., Oh, D. Y., Maiti, K., Kwon, H. B., Cheon, J., Hwang, J. I. & Seong, J. Y., 2008 Feb 29, In : Molecules and cells. 25, 1, p. 91-98 8 p.

Research output: Contribution to journalArticle

Novel glucagon-like peptide-1 agonists and use thereof

Seong, J. Y. & Kim, S. G., 2008 Aug 5, Patent No. 10-0851560

Research output: Patent

2007

Cloning and activation of the bullfrog apelin receptor: Gi/o coupling and high affinity for [Pro1]apelin-13

Moon, M. J., Oh, D. Y., Moon, J. S., Kim, D. K., Hwang, J. I., Lee, J. Y., Kim, J. I., Cho, S., Kwon, H. B. & Seong, J. Y., 2007 Oct 15, In : Molecular and Cellular Endocrinology. 277, 1-2, p. 51-60 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Integrin-linked kinase controls Notch1 signaling by down-regulation of protein stability through Fbw7 ubiquitin ligase

Jung-Soon, M., Mi-Yeon, K., Seung-Ok, H., In-Sook, K., Eun-Jung, A., Kyu, S. L., Mi-Sun, S., Jin-Young, K., Hee-Sae, L., Jeen-Woo, P., Eui-Ju, C., Jae, Y. S., Cheol, J. O., Reinhard, F. & Hee-Sae, P., 2007 Aug, In : Molecular and cellular biology. 27, 15, p. 5565-5574 10 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Molecular evolution of neuropeptide receptors with regard to maintaining high affinity to their authentic ligands

Cho, H. J., Acharjee, S., Moon, M. J., Oh, D. Y., Vaudry, H., Kwon, H. B. & Seong, J. Y., 2007, In : General and Comparative Endocrinology. 153, 1-3, p. 98-107 10 p.

Research output: Contribution to journalShort survey

31 Citations (Scopus)

The novel cellular mechanism of human 5-HT6 receptor through an interaction with fyn

Hyung-Mun, Y., Sunoh, K., Hyun-Ji, K., Evi, K., Jae, I. K., Jae, Y. S., Ja-Hyun, B. & Hyewhon, R., 2007 Feb 23, In : Journal of Biological Chemistry. 282, 8, p. 5496-5505 10 p.

Research output: Contribution to journalArticle

106 Citations (Scopus)
2006

Cellular and Molecular Biology of Orphan G Protein-Coupled Receptors

Oh, D. Y., Kim, K., Kwon, H. B. & Seong, J. Y., 2006, A Survey of Cell Biology. Kwang, J. (ed.). p. 163-218 56 p. (International Review of Cytology; vol. 252).

Research output: Chapter in Book/Report/Conference proceedingChapter

45 Citations (Scopus)

Cooperative actions of Tra2α with 9G8 and SRp30c in the RNA splicing of the gonadotropin-releasing hormone gene transcript

Eonyoung, P., Jin, H., Gi, H. S., Mi, S. L., Sooyoung, C., Sung, H. P., Kyungsook, P., Kun, H. L., Sukwoo, C., Jae, Y. S. & Kyungjin, K., 2006 Jan 6, In : Journal of Biological Chemistry. 281, 1, p. 401-409 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Involvement of the Ser-Glu-Pro motif in ligand species-dependent desensitisation of the rat gonadotrophin-releasing hormone receptor

Song, J. A., Oh, D. Y., Moon, J. S., Geum, D., Kwon, H. B. & Seong, J. Y., 2006 Oct, In : Journal of Neuroendocrinology. 18, 10, p. 757-766 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Vasotocin and mesotocin stimulate the biosynthesis of neurosteroids in the frog brain

Jean-Luc, D. R., Sujata, A., Jae, Y. S., Ludovic, G., David, A., Patrice, B., Arlette, B., Hyuk, B. K., Van, L. T., Georges, P. & Vaudry, H., 2006, In : Journal of Neuroscience. 26, 25, p. 6749-6760 12 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)
2005

Differential effects of gonadotropin-releasing hormone (GnRH)-I and GnRH-II on prostate cancer cell signaling and death

Kaushik, M., Da, Y. O., Jung, S. M., Sujata, A., Jian, H. L., Dong, G. B., Hee-Sae, P., Keesook, L., Young, C. L., Neon, C. J., Kyungjin, K., Hubert, V., Hyuk, B. K. & Jae, Y. S., 2005 Jul, In : Journal of Clinical Endocrinology and Metabolism. 90, 7, p. 4287-4298 12 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Extracellular loop 3 (EL3) and EL3-proximal transmembrane helix 7 of the mammalian type I and type II gonadotropin-releasing hormone (GnRH) receptors determine differential ligand selectivity to GnRH-I and GnRH-II

Li, J. H., Choe, H., Wang, A. F., Maiti, K., Wang, C., Salam, A., Chun, S. Y., Lee, W. K., Kim, K., Kwon, H. B. & Seong, J. Y., 2005 Apr, In : Molecular Pharmacology. 67, 4, p. 1099-1110 12 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

GnRH pre-mRNA splicing: Solving the mystery of a nature's knockout, hpg mouse

Son, G. H., Park, E., Jung, H., Han, J., Lee, K. H., Seong, J. Y. & Kim, K., 2005 Jan 14, In : Biochemical and biophysical research communications. 326, 2, p. 261-267 7 p.

Research output: Contribution to journalShort survey

12 Citations (Scopus)

Membrane-proximal region of the carboxyl terminus of the gonadotropin-releasing hormone receptor (GnRHR) confers differential signal transduction between mammalian and nonmammalian GnRHRs

Oh, D. Y., Song, J. A., Moon, J. S., Moon, M. J., Kim, J. I., Kim, K., Kwon, H. B. & Seong, J. Y., 2005 Mar, In : Molecular Endocrinology. 19, 3, p. 722-731 10 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Molecular cloning and functional characterization of a type-I neurotensin receptor (NTR) and a novel NTR from the bullfrog brain

Li, J. H., Sicard, F., Salam, M. A., Baek, M., LePrince, J., Vaudry, H., Kim, K., Kwon, H. B. & Seong, J. Y., 2005 Jun, In : Journal of Molecular Endocrinology. 34, 3, p. 793-807 15 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2004

Effect of ascorbic acid supplementation on testicular steroidogenesis and germ cell death in cadmium-treated male rats

Gupta, R. S., Kim, J., Gomes, C., Oh, S., Park, J., Im, W. B., Seong, J. Y., Ahn, R. S., Kwon, H. B. & Soh, J., 2004 Jun 30, In : Molecular and Cellular Endocrinology. 221, 1-2, p. 57-66 10 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Identification of amino acid residues that direct differential ligand selectivity of mammalian and nonmammalian V1a type receptors for arginine vasopressin and vasotocin: Insights into molecular coevolution of V1a type receptors and their ligands

Acharjee, S., Do-Rego, J. L., Oh, D. Y., Ahn, R. S., Choe, H., Vaudry, H., Kim, K., Seong, J. Y. & Kwon, H. B., 2004 Dec 24, In : Journal of Biological Chemistry. 279, 52, p. 54445-54453 9 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Molecular cloning, pharmacological characterization, and histochemical distribution of frog vasotocin and mesotocin receptors

Acharjee, S., Do-Rego, J. L., Oh, D. Y., Moon, J. S., Ahn, R. S., Lee, K., Bai, D. G., Vaudry, H., Kwon, H. B. & Seong, J. Y., 2004 Aug, In : Journal of Molecular Endocrinology. 33, 1, p. 293-313 21 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
32 Citations (Scopus)

Proliferation of TSU-Pr1, a human prostatic carcinoma cell line is stimulated by gonadotropin-releasing hormone

Enomoto, M., Seong, J. Y., Kawashima, S. & Park, M. K., 2004 May 7, In : Life Sciences. 74, 25, p. 3141-3152 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2003

Ala/Thr201 in extracellular loop 2 and Leu/Phe290 in transmembrane domain 6 of type 1 frog gonadotropin-releasing hormone receptor confer differential ligand sensitivity and signal transduction

Seong, J. Y., Wang, L., Oh, D. Y., Yun, O., Maiti, K., Li, J. H., Soh, J. M., Choi, H. S., Kim, K., Vaudry, H. & Kwon, H. B., 2003 Feb 1, In : Endocrinology. 144, 2, p. 454-466 13 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)