• 3325 Citations
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1993 …2020

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Activation of central GABAA- but not of GABAB – receptors rapidly reduces pituitary LH release and GnRH gene expression in the preoptic/anterior hypothalamic area of ovariectomized rats

Leonhardt, S., Seong, J. Y., Kim, K., Thorun, Y., Wuttke, W. & Jarry, H., 1995, In : Neuroendocrinology. 61, 6, p. 655-662 8 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)
34 Citations (Scopus)

A gonadotropin-releasing hormone-II antagonist induces autophagy of prostate cancer cells

Dong-Ki, K., Ji, S. Y., Kaushik, M., Jong-Ik, H., Kyungjin, K., Dongseung, S., Younghee, A., Cheolji, L., Byeong-Cheol, K., Hyuk, B. K., Jun, C. & Jae, Y. S., 2009 Feb 1, In : Cancer Research. 69, 3, p. 923-931 9 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Ala/Thr201 in extracellular loop 2 and Leu/Phe290 in transmembrane domain 6 of type 1 frog gonadotropin-releasing hormone receptor confer differential ligand sensitivity and signal transduction

Seong, J. Y., Wang, L., Oh, D. Y., Yun, O., Maiti, K., Li, J. H., Soh, J. M., Choi, H. S., Kim, K., Vaudry, H. & Kwon, H. B., 2003 Feb 1, In : Endocrinology. 144, 2, p. 454-466 13 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Analysis of exonic splicing enhancers in the mouse gonadotropin-releasing hormone (GnRH) gene

Han, J., Seong, J. Y., Kim, K., Wuttke, W. & Jarry, H., 2001 Feb 22, In : Molecular and Cellular Endocrinology. 173, 1-2, p. 157-166 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Analysis of steroid-induced genes in the rat preoptic area-anterior hypothalamus using a differential-display reverse transcriptase-polymerase chain reaction

Park, S., Seong, J. Y., Son, G. H., Kang, S. S., Lee, S., Kim, S. R. & Kim, K., 2001, In : Journal of Neuroendocrinology. 13, 6, p. 531-539 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A Novel Glucagon-Related Peptide (GCRP) and Its Receptor GCRPR Account for Coevolution of Their Family Members in Vertebrates

Park, C. R., Moon, M. J., Park, S., Kim, D. K., Cho, E. B., Millar, R. P., Hwang, J. I. & Seong, J. Y., 2013 Jun 11, In : PloS one. 8, 6, e65420.

Research output: Contribution to journalArticle

21 Citations (Scopus)

A novel long-acting glucagon-like peptide-1 agonist with improved efficacy in insulin secretion and β-cell growth

Kim, H. Y., Hwang, J. I., Moon, M. J. & Seong, J. Y., 2014, In : Endocrinology and Metabolism. 29, 3, p. 320-327 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Anti-Cancer Activity of a Novel Small Molecule Compound That Simultaneously Activates p53 and Inhibits NF-κB Signaling

Hwang, S. G., Park, J., Park, J. Y., Park, C. H., Lee, K. H., Cho, J. W., Hwang, J. I. & Seong, J. Y., 2012 Sep 13, In : PloS one. 7, 9, e44259.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Apoptotic death of prostate cancer cells by a gonadotropin-releasing hormone-II antagonist

Park, S., Han, J. M., Cheon, J., Hwang, J. I. & Seong, J. Y., 2014 Jun 13, In : PloS one. 9, 6, e99723.

Research output: Contribution to journalArticle

9 Citations (Scopus)

A splicing variant of NME1 negatively regulates NF-κB signaling and inhibits cancer metastasis by interacting with IKKβ

You, D. J., Park, C. R., Lee, H. B., Moon, M. J., Kang, J. H., Lee, C., Oh, S. H., Ahn, C., Seong, J. Y. & Hwang, J. I., 2014 Jun 20, In : Journal of Biological Chemistry. 289, 25, p. 17709-17720 12 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Brain-specific chemokine FAM19A5 induces hypothalamic inflammation

Kang, D., Kim, H. R., Kim, K. K., Kim, D. H., Jeong, B., Jin, S., Park, J. W., Seong, J. Y. & Lee, B. J., 2020 Mar 19, In : Biochemical and biophysical research communications. 523, 4, p. 829-834 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Characterization of functional domains in NME1L regulation of NF-κB signaling

You, D. J., Park, C. R., Mander, S., Ahn, C., Seong, J. Y. & Hwang, J. I., 2016 May 1, In : Molecules and cells. 39, 5, p. 403-409 7 p.

Research output: Contribution to journalArticle

Class-C Sox transcription factors control GnRH gene expression via the intronic transcriptional enhancer

Kim, H. D., Choe, H. K., Chung, S., Kim, M., Seong, J. Y., Son, G. H. & Kim, K., 2011 Jul 1, In : Molecular Endocrinology. 25, 7, p. 1184-1196 13 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Cloning and activation of the bullfrog apelin receptor: Gi/o coupling and high affinity for [Pro1]apelin-13

Moon, M. J., Oh, D. Y., Moon, J. S., Kim, D. K., Hwang, J. I., Lee, J. Y., Kim, J. I., Cho, S., Kwon, H. B. & Seong, J. Y., 2007 Oct 15, In : Molecular and Cellular Endocrinology. 277, 1-2, p. 51-60 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Cloning and characterization of androgen receptor from bullfrog, Rana catesbeiana

Chattopadhyay, S., Park, J. H., Seong, J. Y., Kwon, H. B. & Lee, K., 2003 Oct 15, In : General and Comparative Endocrinology. 134, 1, p. 10-17 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III

Kim, D. K., Yun, S., Son, G. H., Hwang, J. I., Park, C. R., Kim, J. I., Kim, K., Vaudry, H. & Seong, J. Y., 2014 May, In : Endocrinology. 155, 5, p. 1864-1873 10 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Competitive PCR for quantitation of gonadotropin-releasing hormone mRNA level in a single micropunch of the rat preoptic area

Kim, K., Jarry, H., Knoke, I., Seong, J. Y., Leonhardt, S. & Wuttke, W., 1993 Nov, In : Molecular and Cellular Endocrinology. 97, 1-2, p. 153-158 6 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Conformational signatures in β-arrestin2 reveal natural biased agonism at a G-protein-coupled receptor

Reyes-Alcaraz, A., Lee, Y. N., Yun, S., Hwang, J. I. & Seong, J. Y., 2018 Dec 1, In : Communications Biology. 1, 1, 128.

Research output: Contribution to journalArticle

Open Access
15 Citations (Scopus)

Cooperative actions of Tra2α with 9G8 and SRp30c in the RNA splicing of the gonadotropin-releasing hormone gene transcript

Eonyoung, P., Jin, H., Gi, H. S., Mi, S. L., Sooyoung, C., Sung, H. P., Kyungsook, P., Kun, H. L., Sukwoo, C., Jae, Y. S. & Kyungjin, K., 2006 Jan 6, In : Journal of Biological Chemistry. 281, 1, p. 401-409 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

CXCL14 enhances proliferation and migration of NCI-H460 human lung cancer cells overexpressing the glycoproteins containing heparan sulfate or sialic acid

Park, C. R., You, D. J., Kim, D. K., Moon, M. J., Lee, C., Oh, S. H., Ahn, C., Seong, J. Y. & Hwang, J. I., 2013 May, In : Journal of cellular biochemistry. 114, 5, p. 1084-1096 13 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Development of spexin-based human galanin receptor type II-specific agonists with increased stability in serum and anxiolytic effect in mice

Reyes-Alcaraz, A., Lee, Y. N., Son, G. H., Kim, N. H., Kim, D. K., Yun, S., Kim, D. H., Hwang, J. I. & Seong, J. Y., 2016 Feb 24, In : Scientific reports. 6, 21453.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Differential desensitization and internalization of three different bullfrog gonadotropin-releasing hormone receptors

Acharjee, S., Maiti, K., Soh, J. M., Im, W. B., Seong, J. Y. & Kwon, H. B., 2002 Aug, In : Molecules and cells. 14, 1, p. 101-107 7 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Differential effects of gonadotropin-releasing hormone (GnRH)-I and GnRH-II on prostate cancer cell signaling and death

Kaushik, M., Da, Y. O., Jung, S. M., Sujata, A., Jian, H. L., Dong, G. B., Hee-Sae, P., Keesook, L., Young, C. L., Neon, C. J., Kyungjin, K., Hubert, V., Hyuk, B. K. & Jae, Y. S., 2005 Jul, In : Journal of Clinical Endocrinology and Metabolism. 90, 7, p. 4287-4298 12 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Differential G protein coupling preference of mammalian and nonmammalian gonadotropin-releasing hormone receptors

Oh, D. Y., Wang, L., Ahn, R. S., Park, J. Y., Seong, J. Y. & Kwon, H. B., 2003 Jul 31, In : Molecular and Cellular Endocrinology. 205, 1-2, p. 89-98 10 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Differential regulation of gonadotropin-releasing hormone (GnRH) receptor expression in the posterior mediobasal hypothalamus by steroid hormones: Implication of GnRH neuronal activity

Seong, J. Y., Kang, S. S., Kam, K., Han, Y. G., Kwon, H. B., Ryu, K. & Kim, K., 1998 Jan, In : Molecular Brain Research. 53, 1-2, p. 226-235 10 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Dimer of arfaptin 2 regulates NF-κB signaling by interacting with IKKβ/NEMO and inhibiting IKKβ kinase activity

You, D. J., Park, C. R., Furlong, M., Koo, O., Lee, C., Ahn, C., Seong, J. Y. & Hwang, J. I., 2015 Nov 1, In : Cellular Signalling. 27, 11, p. 2173-2181 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Distribution and neuronal circuit of spexin 1/2 neurons in the zebrafish CNS

Kim, E., Jeong, I., Chung, A. Y., Kim, S., Kwon, S. H., Seong, J. Y. & Park, H. C., 2019 Dec 1, In : Scientific reports. 9, 1, 5025.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Distribution of galanin receptor 2b neurons and interaction with galanin in the zebrafish central nervous system

Kim, E., Jeong, I., Kim, S., Kim, H. K., Lee, D. W., Kim, B., Seong, J. Y., Bae, Y. K., Ryu, J. H. & Park, H. C., 2016 Aug 15, In : Neuroscience Letters. 628, p. 153-160 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Effect of ascorbic acid supplementation on testicular steroidogenesis and germ cell death in cadmium-treated male rats

Gupta, R. S., Kim, J., Gomes, C., Oh, S., Park, J., Im, W. B., Seong, J. Y., Ahn, R. S., Kwon, H. B. & Soh, J., 2004 Jun 30, In : Molecular and Cellular Endocrinology. 221, 1-2, p. 57-66 10 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Effect of GABAergic compounds on gonadotropin-releasing hormone receptor gene expression in the rat

Seong, J. Y., Jarry, H., Küinemuth, S., Leonhardt, S., Wutke, W. & Kim, K., 1995 Jun, In : Endocrinology. 136, 6, p. 2587-2593 7 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
Open Access
31 Citations (Scopus)

Evolutionarily conserved residues at glucagon-like peptide-1 (GLP-1) receptor core confer ligand-induced receptor activation

Moon, M. J., Kim, H. Y., Park, S., Kim, D. K., Cho, E. B., Park, C. R., You, D. J., Hwang, J. I., Kim, K., Choe, H. & Seong, J. Y., 2012 Feb 3, In : Journal of Biological Chemistry. 287, 6, p. 3873-3884 12 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
3 Citations (Scopus)

Excision of the first intron from the gonadotropin-releasing hormone (GnRH) transcript serves as a key regulatory step for GnRH biosynthesis

Son, G. H., Jung, H., Seong, J. Y., Choe, Y., Geum, D. & Kim, K., 2003 May 16, In : Journal of Biological Chemistry. 278, 20, p. 18037-18044 8 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Exonic splicing enhancer-dependent splicing of the gonadotropin-releasing hormone premessenger ribonucleic acid is mediated by Tra2α, a 40-kilodalton serine/arginine-rich protein

Seong, J. Y., Han, J., Park, S., Wuttke, W., Jarry, H. & Kim, K., 2002 Nov 1, In : Molecular Endocrinology. 16, 11, p. 2426-2438 13 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Expansion of secretin-like G protein-coupled receptors and their peptide ligands via local duplications before and after two rounds of whole-genome duplication

Hwang, J. I., Moon, M. J., Park, S., Kim, D. K., Cho, E. B., Ha, N., Son, G. H., Kim, K., Vaudry, H. & Seong, J. Y., 2013 May, In : Molecular Biology and Evolution. 30, 5, p. 1119-1130 12 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Exploring the molecular structures that confer ligand selectivity for galanin type II and III receptors

Lee, Y. N., Reyes-Alcaraz, A., Yun, S., Lee, C. S., Hwang, J. I. & Seong, J. Y., 2020, In : PloS one. 15, 3, e0230872.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Extracellular loop 3 (EL3) and EL3-proximal transmembrane helix 7 of the mammalian type I and type II gonadotropin-releasing hormone (GnRH) receptors determine differential ligand selectivity to GnRH-I and GnRH-II

Li, J. H., Choe, H., Wang, A. F., Maiti, K., Wang, C., Salam, A., Chun, S. Y., Lee, W. K., Kim, K., Kwon, H. B. & Seong, J. Y., 2005 Apr, In : Molecular Pharmacology. 67, 4, p. 1099-1110 12 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

FAM19A5, a brain-specific chemokine, inhibits RANKL-induced osteoclast formation through formyl peptide receptor 2

Park, M. Y., Kim, H. S., Lee, M., Park, B., Lee, H. Y., Cho, E. B., Seong, J. Y. & Bae, Y. S., 2017 Dec 1, In : Scientific reports. 7, 1, 15575.

Research output: Contribution to journalArticle

12 Citations (Scopus)

FAM19A5 expression during embryogenesis and in the adult traumatic brain of FAM19A5-LacZ Knock-in mice

Shahapal, A., Cho, E. B., Yong, H. J., Jeong, I., Kwak, H., Lee, J. K., Kim, W., Kim, B., Park, H. C., Lee, W. S., Kim, H., Hwang, J. I. & Seong, J. Y., 2019, In : Frontiers in Neuroscience. 13, AUG, 917.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

First intron excision of GnRH pre-mRNA during postnatal development of normal mice and adult hypogonadal mice

Jae Young Seong, Y. S., Bong Won Kim, W. K., Park, S., Gi Hoon Son, H. S. & Kim, K., 2001, In : Endocrinology. 142, 10, p. 4454-4461 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

GABBR2 mutations determine phenotype in rett syndrome and epileptic encephalopathy

Yoo, Y., Jung, J., Lee, Y. N., Lee, Y., Cho, H., Na, E., Hong, J. Y., Kim, E., Lee, J. S., Lee, J. S., Hong, C., Park, S. Y., Wie, J., Miller, K., Shur, N., Clow, C., Ebel, R. S., DeBrosse, S. D., Henderson, L. B., Willaert, R. & 15 others, Castaldi, C., Tikhonova, I., Bilgüvar, K., Mane, S., Kim, K. J., Hwang, Y. S., Lee, S. G., So, I., Lim, B. C., Choi, H. J., Seong, J. Y., Shin, Y. B., Jung, H., Chae, J. H. & Choi, M., 2017 Sep 1, In : Annals of Neurology. 82, 3, p. 466-478 13 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

GnRH-II analogs for selective activation and inhibition of non-mammalian and type-II mammalian GnRH receptors

Maiti, K., Li, J. H., Wang, A. F., Acharjee, S., Kim, W. P., Im, W. B., Kwon, H. B. & Seong, J. Y., 2003 Oct, In : Molecules and cells. 16, 2, p. 173-179 7 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

GnRH pre-mRNA splicing: Role of exonic splicing enhancer

Han, J., Hoon Son, G., Young Seong, J. & Kim, K., 2002, In : Progress in Brain Research. 141, p. 209-219 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Gonadotropin-releasing hormone stimulates the biosynthesis of pregnenolone sulfate and dehydroepiandrosterone sulfate in the hypothalamus

Burel, D., Li, J. H., Do-Rego, J. L., Wang, A. F., Luu-The, V., Pelletier, G., Tillet, Y., Taragnat, C., Kwon, H. B., Seong, J. Y. & Vaudry, H., 2013 Jun 1, In : Endocrinology. 154, 6, p. 2114-2128 15 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

GβL regulates TNFα-induced NF-k{cyrillic}B signaling by directly inhibiting the activation of Ik{cyrillic}B kinase

Kim, Y. L., Kim, J. E., Shin, K. J., Lee, S., Ahn, C., Chung, J., Kim, D. H., Seong, J. Y. & Hwang, J. I., 2008 Nov, In : Cellular Signalling. 20, 11, p. 2127-2133 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Histidine7.36(305) in the conserved peptide receptor activation domain of the gonadotropin releasing hormone receptor couples peptide binding and receptor activation

Mayevu, N. M. I., Choe, H., Abagyan, R., Seong, J. Y., Millar, R. P., Katz, A. A. & Flanagan, C. A., 2015 Feb 5, In : Molecular and Cellular Endocrinology. 402, p. 95-106 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Identification of amino acid residues that direct differential ligand selectivity of mammalian and nonmammalian V1a type receptors for arginine vasopressin and vasotocin: Insights into molecular coevolution of V1a type receptors and their ligands

Acharjee, S., Do-Rego, J. L., Oh, D. Y., Ahn, R. S., Choe, H., Vaudry, H., Kim, K., Seong, J. Y. & Kwon, H. B., 2004 Dec 24, In : Journal of Biological Chemistry. 279, 52, p. 54445-54453 9 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)