• 3325 Citations
  • 31 h-Index
1993 …2020

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Article
2010

Molecular coevolution of kisspeptins and their receptors from fish to mammals

Um, H. N., Han, J. M., Hwang, J. I., Hong, S. I., Vaudry, H. & Seong, J. Y., 2010 Jul, In : Annals of the New York Academy of Sciences. 1200, p. 67-74 8 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Regulation of IκB kinase by GβL through recruitment of the protein phosphatases

You, D. J., Kim, Y. L., Park, C. R., Kim, D. K., Yeom, J., Lee, C., Ahn, C., Seong, J. Y. & Hwang, J. I., 2010 Dec, In : Molecules and cells. 30, 6, p. 527-532 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Splicing variants of the orphan G-protein-coupled receptor GPR56 regulate the activity of transcription factors associated with tumorigenesis

Kim, J. E., Han, J. M., Park, C. R., Shin, K. J., Ahn, C., Seong, J. Y. & Hwang, J. I., 2010 Jan, In : Journal of Cancer Research and Clinical Oncology. 136, 1, p. 47-53 7 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Suppression of NF-κB signaling by KEAP1 regulation of IKKβ activity through autophagic degradation and inhibition of phosphorylation

Kim, J. E., You, D. J., Lee, C., Ahn, C., Seong, J. Y. & Hwang, J. I., 2010 Nov, In : Cellular Signalling. 22, 11, p. 1645-1654 10 p.

Research output: Contribution to journalArticle

113 Citations (Scopus)

Tyr1 and Ile7 of glucose-dependent insulinotropic polypeptide (GIP) confer differential ligand selectivity toward GIP and glucagon-like peptide-1 receptors

Moon, M. J., Kim, H. Y., Kim, S. G., Park, J., Choi, D. S., Hwang, J. I. & Seong, J. Y., 2010 Aug, In : Molecules and cells. 30, 2, p. 149-154 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2009

A gonadotropin-releasing hormone-II antagonist induces autophagy of prostate cancer cells

Dong-Ki, K., Ji, S. Y., Kaushik, M., Jong-Ik, H., Kyungjin, K., Dongseung, S., Younghee, A., Cheolji, L., Byeong-Cheol, K., Hyuk, B. K., Jun, C. & Jae, Y. S., 2009 Feb 1, In : Cancer Research. 69, 3, p. 923-931 9 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Lysophosphatidic acid signaling through LPA receptor subtype 1 induces colony scattering of gastrointestinal cancer cells

Shin, K. J., Kim, Y. L., Lee, S., Kim, D. K., Ahn, C., Chung, J., Seong, J. Y. & Hwang, J. I., 2009 Jan, In : Journal of Cancer Research and Clinical Oncology. 135, 1, p. 45-52 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Molecular cloning of the bullfrog kisspeptin receptor GPR54 with high sensitivity to Xenopus kisspeptin

Moon, J. S., Lee, Y. R., Oh, D. Y., Hwang, J. I., Lee, J. Y., Kim, J. I., Vaudry, H., Kwon, H. B. & Seong, J. Y., 2009 Jan, In : Peptides. 30, 1, p. 171-179 9 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Molecular evolution of multiple forms of kisspeptins and GPR54 receptors in vertebrates

Yeo, R. L., Tsunekawa, K., Mi, J. M., Haet, N. U., Hwang, J. I., Osugi, T., Otaki, N., Sunakawa, Y., Kim, K., Vaudry, H., Hyuk, B. K., Seong, J. Y. & Tsutsui, K., 2009 Jun, In : Endocrinology. 150, 6, p. 2837-2846 10 p.

Research output: Contribution to journalArticle

172 Citations (Scopus)

Molecular interaction between kisspeptin decapeptide analogs and a lipid membrane

Lee, J. Y., Moon, J. S., Eu, Y. J., Lee, C. W., Yang, S. T., Lee, S. K., Jung, H. H., Kim, H. H., Rhim, H., Seong, J. Y. & Kim, J. I., 2009 May 15, In : Archives of Biochemistry and Biophysics. 485, 2, p. 109-114 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Nova-1 mediates glucocorticoid-induced inhibition of Pre-mRNA splicing of gonadotropin-releasing hormone transcripts

Park, E., Lee, M. S., Baik, S. M., Cho, E. B., Son, G. H., Seong, J. Y., Lee, K. H. & Kim, K., 2009 May 8, In : Journal of Biological Chemistry. 284, 19, p. 12792-12800 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2008
5 Citations (Scopus)

GβL regulates TNFα-induced NF-k{cyrillic}B signaling by directly inhibiting the activation of Ik{cyrillic}B kinase

Kim, Y. L., Kim, J. E., Shin, K. J., Lee, S., Ahn, C., Chung, J., Kim, D. H., Seong, J. Y. & Hwang, J. I., 2008 Nov, In : Cellular Signalling. 20, 11, p. 2127-2133 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92

Oh, D. Y., Jung, M. Y., Mi, J. M., Jong-Ik, H., Han, C., Ju, Y. L., Jae, I. K., Sunoh, K., Hyewhon, R., David, K. O. D., Michael, J. W., Heung, S. N., Min, G. L., Hyuk, B. K., Kyungjin, K. & Jae, Y. S., 2008 Jul 25, In : Journal of Biological Chemistry. 283, 30, p. 21054-21064 11 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)

Involvement of amino acids flanking Glu7.32 of the Gonadotropin-releasing hormone receptor in the selectivity of antagonists

Wang, C., Oh, D. Y., Maiti, K., Kwon, H. B., Cheon, J., Hwang, J. I. & Seong, J. Y., 2008 Feb 29, In : Molecules and cells. 25, 1, p. 91-98 8 p.

Research output: Contribution to journalArticle

2007

Cloning and activation of the bullfrog apelin receptor: Gi/o coupling and high affinity for [Pro1]apelin-13

Moon, M. J., Oh, D. Y., Moon, J. S., Kim, D. K., Hwang, J. I., Lee, J. Y., Kim, J. I., Cho, S., Kwon, H. B. & Seong, J. Y., 2007 Oct 15, In : Molecular and Cellular Endocrinology. 277, 1-2, p. 51-60 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Integrin-linked kinase controls Notch1 signaling by down-regulation of protein stability through Fbw7 ubiquitin ligase

Jung-Soon, M., Mi-Yeon, K., Seung-Ok, H., In-Sook, K., Eun-Jung, A., Kyu, S. L., Mi-Sun, S., Jin-Young, K., Hee-Sae, L., Jeen-Woo, P., Eui-Ju, C., Jae, Y. S., Cheol, J. O., Reinhard, F. & Hee-Sae, P., 2007 Aug, In : Molecular and cellular biology. 27, 15, p. 5565-5574 10 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

The novel cellular mechanism of human 5-HT6 receptor through an interaction with fyn

Hyung-Mun, Y., Sunoh, K., Hyun-Ji, K., Evi, K., Jae, I. K., Jae, Y. S., Ja-Hyun, B. & Hyewhon, R., 2007 Feb 23, In : Journal of Biological Chemistry. 282, 8, p. 5496-5505 10 p.

Research output: Contribution to journalArticle

106 Citations (Scopus)
2006

Cooperative actions of Tra2α with 9G8 and SRp30c in the RNA splicing of the gonadotropin-releasing hormone gene transcript

Eonyoung, P., Jin, H., Gi, H. S., Mi, S. L., Sooyoung, C., Sung, H. P., Kyungsook, P., Kun, H. L., Sukwoo, C., Jae, Y. S. & Kyungjin, K., 2006 Jan 6, In : Journal of Biological Chemistry. 281, 1, p. 401-409 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Involvement of the Ser-Glu-Pro motif in ligand species-dependent desensitisation of the rat gonadotrophin-releasing hormone receptor

Song, J. A., Oh, D. Y., Moon, J. S., Geum, D., Kwon, H. B. & Seong, J. Y., 2006 Oct, In : Journal of Neuroendocrinology. 18, 10, p. 757-766 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Vasotocin and mesotocin stimulate the biosynthesis of neurosteroids in the frog brain

Jean-Luc, D. R., Sujata, A., Jae, Y. S., Ludovic, G., David, A., Patrice, B., Arlette, B., Hyuk, B. K., Van, L. T., Georges, P. & Vaudry, H., 2006, In : Journal of Neuroscience. 26, 25, p. 6749-6760 12 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)
2005

Differential effects of gonadotropin-releasing hormone (GnRH)-I and GnRH-II on prostate cancer cell signaling and death

Kaushik, M., Da, Y. O., Jung, S. M., Sujata, A., Jian, H. L., Dong, G. B., Hee-Sae, P., Keesook, L., Young, C. L., Neon, C. J., Kyungjin, K., Hubert, V., Hyuk, B. K. & Jae, Y. S., 2005 Jul, In : Journal of Clinical Endocrinology and Metabolism. 90, 7, p. 4287-4298 12 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Extracellular loop 3 (EL3) and EL3-proximal transmembrane helix 7 of the mammalian type I and type II gonadotropin-releasing hormone (GnRH) receptors determine differential ligand selectivity to GnRH-I and GnRH-II

Li, J. H., Choe, H., Wang, A. F., Maiti, K., Wang, C., Salam, A., Chun, S. Y., Lee, W. K., Kim, K., Kwon, H. B. & Seong, J. Y., 2005 Apr, In : Molecular Pharmacology. 67, 4, p. 1099-1110 12 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Membrane-proximal region of the carboxyl terminus of the gonadotropin-releasing hormone receptor (GnRHR) confers differential signal transduction between mammalian and nonmammalian GnRHRs

Oh, D. Y., Song, J. A., Moon, J. S., Moon, M. J., Kim, J. I., Kim, K., Kwon, H. B. & Seong, J. Y., 2005 Mar, In : Molecular Endocrinology. 19, 3, p. 722-731 10 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Molecular cloning and functional characterization of a type-I neurotensin receptor (NTR) and a novel NTR from the bullfrog brain

Li, J. H., Sicard, F., Salam, M. A., Baek, M., LePrince, J., Vaudry, H., Kim, K., Kwon, H. B. & Seong, J. Y., 2005 Jun, In : Journal of Molecular Endocrinology. 34, 3, p. 793-807 15 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2004

Effect of ascorbic acid supplementation on testicular steroidogenesis and germ cell death in cadmium-treated male rats

Gupta, R. S., Kim, J., Gomes, C., Oh, S., Park, J., Im, W. B., Seong, J. Y., Ahn, R. S., Kwon, H. B. & Soh, J., 2004 Jun 30, In : Molecular and Cellular Endocrinology. 221, 1-2, p. 57-66 10 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Identification of amino acid residues that direct differential ligand selectivity of mammalian and nonmammalian V1a type receptors for arginine vasopressin and vasotocin: Insights into molecular coevolution of V1a type receptors and their ligands

Acharjee, S., Do-Rego, J. L., Oh, D. Y., Ahn, R. S., Choe, H., Vaudry, H., Kim, K., Seong, J. Y. & Kwon, H. B., 2004 Dec 24, In : Journal of Biological Chemistry. 279, 52, p. 54445-54453 9 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Molecular cloning, pharmacological characterization, and histochemical distribution of frog vasotocin and mesotocin receptors

Acharjee, S., Do-Rego, J. L., Oh, D. Y., Moon, J. S., Ahn, R. S., Lee, K., Bai, D. G., Vaudry, H., Kwon, H. B. & Seong, J. Y., 2004 Aug, In : Journal of Molecular Endocrinology. 33, 1, p. 293-313 21 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
32 Citations (Scopus)

Proliferation of TSU-Pr1, a human prostatic carcinoma cell line is stimulated by gonadotropin-releasing hormone

Enomoto, M., Seong, J. Y., Kawashima, S. & Park, M. K., 2004 May 7, In : Life Sciences. 74, 25, p. 3141-3152 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2003

Ala/Thr201 in extracellular loop 2 and Leu/Phe290 in transmembrane domain 6 of type 1 frog gonadotropin-releasing hormone receptor confer differential ligand sensitivity and signal transduction

Seong, J. Y., Wang, L., Oh, D. Y., Yun, O., Maiti, K., Li, J. H., Soh, J. M., Choi, H. S., Kim, K., Vaudry, H. & Kwon, H. B., 2003 Feb 1, In : Endocrinology. 144, 2, p. 454-466 13 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Cloning and characterization of androgen receptor from bullfrog, Rana catesbeiana

Chattopadhyay, S., Park, J. H., Seong, J. Y., Kwon, H. B. & Lee, K., 2003 Oct 15, In : General and Comparative Endocrinology. 134, 1, p. 10-17 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Differential G protein coupling preference of mammalian and nonmammalian gonadotropin-releasing hormone receptors

Oh, D. Y., Wang, L., Ahn, R. S., Park, J. Y., Seong, J. Y. & Kwon, H. B., 2003 Jul 31, In : Molecular and Cellular Endocrinology. 205, 1-2, p. 89-98 10 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Excision of the first intron from the gonadotropin-releasing hormone (GnRH) transcript serves as a key regulatory step for GnRH biosynthesis

Son, G. H., Jung, H., Seong, J. Y., Choe, Y., Geum, D. & Kim, K., 2003 May 16, In : Journal of Biological Chemistry. 278, 20, p. 18037-18044 8 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

GnRH-II analogs for selective activation and inhibition of non-mammalian and type-II mammalian GnRH receptors

Maiti, K., Li, J. H., Wang, A. F., Acharjee, S., Kim, W. P., Im, W. B., Kwon, H. B. & Seong, J. Y., 2003 Oct, In : Molecules and cells. 16, 2, p. 173-179 7 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Preferential ligand selectivity of the monkey type-II gonadotropin- releasing hormone (GnRH) receptor for GnRH-2 and its analogs

Wang, A. F., Li, J. H., Maiti, K., Kim, W. P., Kang, H. M., Seong, J. Y. & Kwon, H. B., 2003 Nov 14, In : Molecular and Cellular Endocrinology. 209, 1-2, p. 33-42 10 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2002

Differential desensitization and internalization of three different bullfrog gonadotropin-releasing hormone receptors

Acharjee, S., Maiti, K., Soh, J. M., Im, W. B., Seong, J. Y. & Kwon, H. B., 2002 Aug, In : Molecules and cells. 14, 1, p. 101-107 7 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Exonic splicing enhancer-dependent splicing of the gonadotropin-releasing hormone premessenger ribonucleic acid is mediated by Tra2α, a 40-kilodalton serine/arginine-rich protein

Seong, J. Y., Han, J., Park, S., Wuttke, W., Jarry, H. & Kim, K., 2002 Nov 1, In : Molecular Endocrinology. 16, 11, p. 2426-2438 13 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

GnRH pre-mRNA splicing: Role of exonic splicing enhancer

Han, J., Hoon Son, G., Young Seong, J. & Kim, K., 2002, In : Progress in Brain Research. 141, p. 209-219 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2001

Analysis of exonic splicing enhancers in the mouse gonadotropin-releasing hormone (GnRH) gene

Han, J., Seong, J. Y., Kim, K., Wuttke, W. & Jarry, H., 2001 Feb 22, In : Molecular and Cellular Endocrinology. 173, 1-2, p. 157-166 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Analysis of steroid-induced genes in the rat preoptic area-anterior hypothalamus using a differential-display reverse transcriptase-polymerase chain reaction

Park, S., Seong, J. Y., Son, G. H., Kang, S. S., Lee, S., Kim, S. R. & Kim, K., 2001, In : Journal of Neuroendocrinology. 13, 6, p. 531-539 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

First intron excision of GnRH pre-mRNA during postnatal development of normal mice and adult hypogonadal mice

Jae Young Seong, Y. S., Bong Won Kim, W. K., Park, S., Gi Hoon Son, H. S. & Kim, K., 2001, In : Endocrinology. 142, 10, p. 4454-4461 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Inhibitory activity of alternative splice variants of the bullfrog GnRH receptor-3 on wild-type receptor signaling

Wang, L., Oh, D. Y., Bogerd, J., Choi, H. S., Ahn, R. S., Seong, J. Y. & Kwon, H. B., 2001, In : Endocrinology. 142, 9, p. 4015-4025 11 p.

Research output: Contribution to journalArticle

Open Access
38 Citations (Scopus)

Three distinct types of GnRH receptor characterized in the bullfrog

Wang, L., Bogerd, J., Choi, H. S., Seong, J. Y., Soh, J. M., Chun, S. Y., Blomenröhr, M., Troskie, B. E., Millar, R. P., Yu, W. H., McCann, S. M. & Kwon, H. B., 2001 Jan 2, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 1, p. 361-366 6 p.

Research output: Contribution to journalArticle

Open Access
141 Citations (Scopus)
1999
Open Access
31 Citations (Scopus)
22 Citations (Scopus)
1998

Differential regulation of gonadotropin-releasing hormone (GnRH) receptor expression in the posterior mediobasal hypothalamus by steroid hormones: Implication of GnRH neuronal activity

Seong, J. Y., Kang, S. S., Kam, K., Han, Y. G., Kwon, H. B., Ryu, K. & Kim, K., 1998 Jan, In : Molecular Brain Research. 53, 1-2, p. 226-235 10 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Noradrenergic neurotoxin suppresses gonadotropin-releasing hormone (GnRH) and GnRH receptor gene expression in ovariectomized and steroid-treated rats

Kang, S. S., Son, G. H., Seong, J. Y., Choi, D., Kwon, H. B., Lee, C. C. & Kim, K., 1998 Dec, In : Journal of Neuroendocrinology. 10, 12, p. 911-918 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
1995

Activation of central GABAA- but not of GABAB – receptors rapidly reduces pituitary LH release and GnRH gene expression in the preoptic/anterior hypothalamic area of ovariectomized rats

Leonhardt, S., Seong, J. Y., Kim, K., Thorun, Y., Wuttke, W. & Jarry, H., 1995, In : Neuroendocrinology. 61, 6, p. 655-662 8 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)
34 Citations (Scopus)