• 992 Citations
  • 14 h-Index
19992020

Research output per year

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Research Output

  • 992 Citations
  • 14 h-Index
  • 29 Article
  • 10 Review article
  • 1 Conference contribution
2020

Engineered human FcγRIIa fusion: A novel strategy to extend serum half-life of therapeutic proteins

Jo, M., Ko, S., Hwang, B., Min, S. W., Ha, J. Y., Lee, J. C., Jang, S. E. & Jung, S. T., 2020 Aug 1, In : Biotechnology and Bioengineering. 117, 8, p. 2351-2361 11 p.

Research output: Contribution to journalArticle

Reprogramming the constant region of immunoglobulin g subclasses for enhanced therapeutic potency against cancer

Kang, T. H. & Jung, S. T., 2020 Mar, In : Biomolecules. 10, 3, 382.

Research output: Contribution to journalReview article

Open Access
2019

Boosting therapeutic potency of antibodies by taming Fc domain functions

Kang, T. H. & Jung, S. T., 2019 Nov 1, In : Experimental and Molecular Medicine. 51, 11, 138.

Research output: Contribution to journalReview article

Open Access
1 Citation (Scopus)

Computer-based engineering of thermostabilized antibody fragments

Lee, J., Der, B. S., Karamitros, C. S., Li, W., Marshall, N. M., Lungu, O. I., Miklos, A. E., Xu, J., Kang, T. H., Lee, C. H., Tan, B., Hughes, R. A., Jung, S. T., Ippolito, G. C., Gray, J. J., Zhang, Y., Kuhlman, B., Georgiou, G. & Ellington, A. D., 2019 Jan 1, (Accepted/In press) In : AIChE Journal. e16864.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Construction of an immunotoxin via site-specific conjugation of anti-Her2 IgG and engineered Pseudomonas exotoxin A

Lee, B. S., Lee, Y., Park, J., Jeong, B. S., Jo, M., Jung, S. T. & Yoo, T. H., 2019 Jun 21, In : Journal of Biological Engineering. 13, 1, 56.

Research output: Contribution to journalArticle

Open Access

Engineered Arabidopsis Blue Light Receptor LOV Domain Variants with Improved Quantum Yield, Brightness, and Thermostability

Ko, S., Hwang, B., Na, J. H., Lee, J. & Jung, S. T., 2019 Jan 1, (Accepted/In press) In : Journal of agricultural and food chemistry.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Optimal combination of beneficial mutations for improved ADCC effector function of aglycosylated antibodies

Yoon, H. W., Jo, M., Ko, S., Kwon, H. S., Lim, C. S., Ko, B. J., Lee, J. C. & Jung, S. T., 2019 Oct, In : Molecular Immunology. 114, p. 62-71 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

Development of Single-Chain Antibodies Specific to Lysophosphatidic Acid Receptor 2

Son, S. H., Baek, S. I., Ju, M. S., Han, S. G., Jung, S. T. & Yu, Y. G., 2018 Apr 1, In : Bulletin of the Korean Chemical Society. 39, 4, p. 489-494 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Engineered aglycosylated full-length IgG Fc variants exhibiting improved FcγRIIIa binding and tumor cell clearance

Jo, M., Kwon, H. S., Lee, K. H., Lee, J. C. & Jung, S. T., 2018 Feb 17, In : mAbs. 10, 2, p. 278-289 12 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)

Escherichia coli inner membrane display system for high-throughput screening of dimeric proteins

Jo, M., Hwang, B., Yoon, H. W. & Jung, S. T., 2018 Dec 1, In : Biotechnology and Bioengineering. 115, 12, p. 2849-2858 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2017

A synthetic library for rapid isolation of humanized single-domain antibodies

Ju, M. S., Min, S. W., Lee, S. M., Kwon, H. S., Park, J. C., Lee, J. C. & Jung, S. T., 2017 Jun 1, In : Biotechnology and Bioprocess Engineering. 22, 3, p. 239-247 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Detection and purification of backbone-cyclized proteins using a bacterially expressed anti-myc-tag single chain antibody

Chauhan, S., Hou, C. Y., Jung, S. T. & Kang, T. J., 2017 Sep 1, In : Analytical Biochemistry. 532, p. 38-44 7 p.

Research output: Contribution to journalArticle

Determination of the endothelin-1 recognition sites of endothelin receptor type A by the directed-degeneration method

Han, S. G., Ko, S., Lee, W. K., Jung, S. T. & Yu, Y. G., 2017 Dec 1, In : Scientific reports. 7, 1, 7577.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2016

Engineering therapeutic antibodies targeting G-protein-coupled receptors

Jo, M. & Jung, S. T., 2016 Feb 5, In : Experimental & molecular medicine. 48, p. e207

Research output: Contribution to journalReview article

Open Access
29 Citations (Scopus)

The Highly Evolvable Antibody Fc Domain

Park, H. I., Yoon, H. W. & Jung, S. T., 2016 Nov 1, In : Trends in Biotechnology. 34, 11, p. 895-908 14 p.

Research output: Contribution to journalReview article

17 Citations (Scopus)
2015

Engineering antibodies for dual specificity and enhanced potency

Ko, S. & Jung, S. T., 2015 Apr 22, In : Biotechnology and Bioprocess Engineering. 20, 2, p. 201-210 10 p., 1.

Research output: Contribution to journalReview article

3 Citations (Scopus)

Structural consequences of aglycosylated IgG Fc variants evolved for FcγRI binding

Ju, M. S., Na, J. H., Yu, Y. G., Kim, J. Y., Jeong, C. & Jung, S. T., 2015 Oct 1, In : Molecular Immunology. 67, 2, p. 350-356 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2014

Aglycosylated full-length IgG antibodies: Steps toward next-generation immunotherapeutics

Ju, M. S. & Jung, S. T., 2014 Jan 1, In : Current Opinion in Biotechnology. 30, p. 128-139 12 p.

Research output: Contribution to journalReview article

31 Citations (Scopus)

Engineering an aglycosylated Fc variant for enhanced FcγRI engagement and pH-dependent human FcRn binding

Jung, S. T., Kang, T. H. & Kim, D. I., 2014 Nov 20, In : Biotechnology and Bioprocess Engineering. 19, 5, p. 780-789 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

High-resolution antibody dynamics of vaccine-induced immune responses

Laserson, U., Vigneault, F., Gadala-Maria, D., Yaari, G., Uduman, M., Vander Heiden, J. A., Kelton, W., Jung, S. T., Liu, Y., Laserson, J., Chari, R., Lee, J. H., Bachelet, I., Hickey, B., Lieberman-Aiden, E., Hanczaruk, B., Simen, B. B., Egholm, M., Koller, D., Georgiou, G. & 2 others, Kleinstein, S. H. & Church, G. M., 2014 Apr 1, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 13, p. 4928-4933 6 p.

Research output: Contribution to journalArticle

Open Access
101 Citations (Scopus)
2013

Development of a single chain antibody using a phage display cloning method for the detection of 2,4-dinitrotoluene

Na, J. H., Joo, M. S., Lee, W. K., Shim, H., Lim, S. H., Taek Jung, S. & Gyu Yu, Y., 2013 Feb 20, In : Bulletin of the Korean Chemical Society. 34, 2, p. 460-464 5 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Effective phagocytosis of low Her2 tumor cell lines with engineered, aglycosylated igg displaying high FcγRIIa affinity and selectivity

Jung, S. T., Kelton, W., Kang, T. H., Ng, D. T. W., Andersen, J. T., Sandlie, I., Sarkar, C. A. & Georgiou, G., 2013 Feb 15, In : ACS Chemical Biology. 8, 2, p. 368-375 8 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Molecular deconvolution of the monoclonal antibodies that comprise the polyclonal serum response

Wine, Y., Boutz, D. R., Lavinder, J. J., Miklos, A. E., Hughes, R. A., Hoi, K. H., Jung, S. T., Horton, A. P., Murrin, E. M., Ellington, A. D., Marcotte, E. M. & Georgiou, G., 2013 Feb 19, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 8, p. 2993-2998 6 p.

Research output: Contribution to journalArticle

Open Access
85 Citations (Scopus)

Tailoring immunoglobulin Fc for highly potent and serum-stable therapeutic antibodies

Jung, S. T., 2013 Jul, In : Biotechnology and Bioprocess Engineering. 18, 4, p. 625-636 12 p.

Research output: Contribution to journalReview article

10 Citations (Scopus)
2012

Recent development of highly sensitive Protease assay methods: Signal amplification through enzyme cascades

Yoon, H. K., Jung, S. T., Kim, J. H. & Yoo, T. H., 2012, In : Biotechnology and Bioprocess Engineering. 17, 6, p. 1113-1119 7 p.

Research output: Contribution to journalReview article

14 Citations (Scopus)

Revisiting the role of glycosylation in the structure of human IgG Fc

Borrok, M. J., Jung, S. T., Kang, T. H., Monzingo, A. F. & Georgiou, G., 2012 Sep 21, In : ACS Chemical Biology. 7, 9, p. 1596-1602 7 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)

Structure-guided directed evolution of highly selective P450-based magnetic resonance imaging sensors for dopamine and serotonin

Brustad, E. M., Lelyveld, V. S., Snow, C. D., Crook, N., Jung, S. T., Martinez, F. M., Scholl, T. J., Jasanoff, A. & Arnold, F. H., 2012 Sep 14, In : Journal of Molecular Biology. 422, 2, p. 245-262 18 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2011

Bypassing glycosylation: Engineering aglycosylated full-length IgG antibodies for human therapy

Jung, S. T., Kang, T. H., Kelton, W. & Georgiou, G., 2011 Dec, In : Current Opinion in Biotechnology. 22, 6, p. 858-867 10 p.

Research output: Contribution to journalReview article

68 Citations (Scopus)

Cytochrome P450: Taming a wild type enzyme

Jung, S. T., Lauchli, R. & Arnold, F. H., 2011 Dec, In : Current Opinion in Biotechnology. 22, 6, p. 809-817 9 p.

Research output: Contribution to journalReview article

186 Citations (Scopus)
2010

Aglycosylated IgG variants expressed in bacteria that selectively bind FcγRI potentiate tumor cell killing by monocyte-dendritic cells

Jung, S. T., Reddy, S. T., Kang, T. H., Borrok, M. J., Sandlie, I., Tucker, P. W. & Georgiou, G., 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 2, p. 604-609 6 p.

Research output: Contribution to journalArticle

Open Access
112 Citations (Scopus)

Efficient expression and purification of human aglycosylated Fcγ receptors in Escherichia coli

Jung, S. T., Kang, T. H. & Georgiou, G., 2010 Sep 1, In : Biotechnology and Bioengineering. 107, 1, p. 21-30 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Enrichment of Escherichia coli spheroplasts displaying scFv antibodies specific for antigens expressed on the human cell surface

Qiu, J. K., Jung, S. T., Georgiou, G. & Hang, H. Y., 2010 Dec, In : Applied Microbiology and Biotechnology. 88, 6, p. 1385-1391 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2008

Engineering of aglycosylated antibody Fc for selective binding to Fc gamma receptors and effector function

Jung, S. T., Kang, T. H., Sandlie, I., Tucker, P. W. & Georgiou, G., 2008, AIChE100 - 2008 AIChE Annual Meeting, Conference Proceedings. (AIChE Annual Meeting, Conference Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2007

Binding and enrichment of Escherichia coli spheroplasts expressing inner membrane tethered scFv antibodies on surface immobilized antigens

Sang, T. J., Ki, J. J., Iverson, B. L. & Georgiou, G., 2007 Sep 1, In : Biotechnology and Bioengineering. 98, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2003

Expression and Purification of Enzymatically Active Forms of the Human Lysyl Oxidase-like Protein 4

Kim, M. S., Kim, S. S., Jung, S. T., Park, J. Y., Yoo, H. W., Ko, J., Csiszar, K., Choi, S. Y. & Kim, Y., 2003 Dec 26, In : Journal of Biological Chemistry. 278, 52, p. 52071-52074 4 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Purification of enzymatically active human lysyl oxidase and lysyl oxidase-like protein from Escherichia coli inclusion bodies

Jung, S. T., Kim, M. S., Seo, J. Y., Kim, H. C. & Kim, Y., 2003 Oct, In : Protein Expression and Purification. 31, 2, p. 240-246 7 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
1999

An efficient translational termination of human erythropoietin in Escherichia coli by altering the base following the stop codon

Kang, S. H., Jung, S. T., Kang, T. J., Kim, R. G., Suh, S. H., Woo, J. H., Lee, E. Y. & Choi, C. Y., 1999, In : Biotechnology Techniques. 13, 11, p. 761-764 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A simple regression method for determining the quantity of translated protein in a cell-free protein synthesis system

Kang, T. J., Kang, S. H., Jung, S. T., Lee, E. Y. & Choi, C. Y., 1999 Sep, In : Journal of Bioscience and Bioengineering. 88, 3, p. 345-347 3 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)