• 3729 Citations
  • 36 h-Index
19962020

Research output per year

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Research Output

  • 3729 Citations
  • 36 h-Index
  • 107 Article
  • 7 Patent
  • 1 Review article
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Article
2020

HSP90A inhibition promotes anti-tumor immunity by reversing multi-modal resistance and stem-like property of immune-refractory tumors

Song, K. H., Oh, S. J., Kim, S., Cho, H., Lee, H. J., Song, J. S., Chung, J. Y., Cho, E., Lee, J., Jeon, S., Yee, C., Lee, K. M., Hewitt, S. M., Kim, J. H., Woo, S. R. & Kim, T. W., 2020 Dec 1, In : Nature communications. 11, 1, 562.

Research output: Contribution to journalArticle

Open Access
2019

TLR9 acts as a sensor for tumor-released DNA to modulate anti-tumor immunity after chemotherapy

Kang, T. H., Mao, C. P., Kim, Y. S., Kim, T. W., Yang, A., Lam, B., Tseng, S. H., Farmer, E., Park, Y. M. & Hung, C. F., 2019 Oct 16, In : Journal for ImmunoTherapy of Cancer. 7, 1, 260.

Research output: Contribution to journalArticle

Open Access
2018

Mitochondrial reprogramming via ATP5H loss promotes multimodal cancer therapy resistance

Song, K. H., Kim, J. H., Lee, Y. H., Bae, H. C., Lee, H. J., Woo, S. R., Oh, S. J., Lee, K-M., Yee, C., Kim, B. W., Cho, H., Chung, E. J., Chung, J. Y., Hewitt, S. M., Chung, T. W., Ha, K. T., Bae, Y. K., Mao, C. P., Yang, A., Wu, T. C. & 1 others, Kim, T. W., 2018 Aug 31, In : Journal of Clinical Investigation. 128, 9, p. 4098-4114 17 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Nonimmunogenetic Viral Capsid Carrier with Cancer Targeting Activity

Lee, B. R., Jo, E., Yoon, H. Y., Yoon, C. J., Lee, H. J., Kwon, K. C., Kim, T. W. & Lee, J., 2018 Aug 1, In : Advanced Science. 5, 8, 1800494.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Stabilization of HDAC1 via TCL1-pAKT-CHFR axis is a key element for NANOG-mediated multi-resistance and stem-like phenotype in immune-edited tumor cells

Woo, S. R., Lee, H. J., Oh, S. J., Kim, S., Park, S. H., Lee, J., Song, K. H. & Kim, T. W., 2018 Sep 10, In : Biochemical and Biophysical Research Communications. 503, 3, p. 1812-1818 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Targeting cyclin D-CDK4/6 sensitizes immune-refractory cancer by blocking the SCP3–NANOG axis

Oh, S. J., Cho, H., Kim, S., Noh, K. H., Song, K. H., Lee, H. J., Woo, S. R., Kim, S., Choi, C. H., Chung, J. Y., Hewitt, S. M., Kim, J. H., Baek, S., Lee, K-M., Yee, C., Park, H. C. & Kim, T. W., 2018 May 15, In : Cancer Research. 78, 10, p. 2638-2653 16 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2017

A PEGylated hyaluronic acid conjugate for targeted cancer immunotherapy

Shin, J. M., Oh, S. J., Kwon, S., Deepagan, V. G., Lee, M., Song, S. H., Lee, H. J., Kim, S., Song, K. H., Kim, T. W. & Park, J. H., 2017, (Accepted/In press) In : Journal of Controlled Release.

Research output: Contribution to journalArticle

18 Citations (Scopus)

API5 confers cancer stem cell-like properties through the FGF2-NANOG axis

Song, K. H., Cho, H., Kim, S., Lee, H. J., Oh, S. J., Woo, S. R., Hong, S. O., Jang, H. S., Noh, K. H., Choi, C. H., Chung, J. Y., Hewitt, S. M., Kim, J. H., Son, M., Kim, S. H., Lee, B. I., Park, H. C., Bae, Y. K. & Kim, T. W., 2017 Jan 1, In : Oncogenesis. 6, 1, e285.

Research output: Contribution to journalArticle

10 Citations (Scopus)

API5 induces cisplatin resistance through FGFR signaling in human cancer cells

Jang, H. S., Woo, S. R., Song, K. H., Cho, H., Chay, D. B., Hong, S. O., Lee, H. J., Oh, S. J., Chung, J. Y., Kim, J. H. & Kim, T. W., 2017 Sep 8, In : Experimental & molecular medicine. 49, 9, p. e374

Research output: Contribution to journalArticle

4 Citations (Scopus)

HDAC1 upregulation by NANOG promotes multidrug resistance and a stem-like phenotype in immune edited tumor cells

Song, K. H., Choi, C. H., Lee, H. J., Oh, S. J., Woo, S. R., Hong, S. O., Noh, K. H., Cho, H., Chung, E. J., Kim, J. H., Chung, J. Y., Hewitt, S. M., Baek, S., Lee, K-M., Yee, C., Son, M., Mao, C. P., Wu, T. C. & Kim, T. W., 2017 Sep 15, In : Cancer Research. 77, 18, p. 5039-5053 15 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

REP1 inhibits FOXO3-mediated apoptosis to promote cancer cell survival

Song, K. H., Woo, S. R., Chung, J. Y., Lee, H. J., Oh, S. J., Hong, S. O., Shim, J., Kim, Y. N., Rho, S. B., Hong, S. M., Cho, H., Hibi, M., Bae, D. J., Kim, S. Y., Kim, M. G., Kim, T. W. & Bae, Y. K., 2017 Jan 5, In : Cell Death and Disease. 8, 1, e2536.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Synaptonemal complex protein 3 is associated with lymphangiogenesis in non-small cell lung cancer patients with lymph node metastasis

Kitano, H., Chung, J. Y., Noh, K. H., Lee, Y. H., Kim, T. W., Lee, S. H., Eo, S. H., Cho, H. J., Choi, C. H., Inoue, S., Hanaoka, J., Fukuoka, J. & Hewitt, S. M., 2017, In : Journal of Translational Medicine. 15, 1, 138.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2016

Engineered Human Ferritin Nanoparticles for Direct Delivery of Tumor Antigens to Lymph Node and Cancer Immunotherapy

Lee, B. R., Ko, H. K., Ryu, J. H., Ahn, K. Y., Lee, Y. H., Oh, S. J., Na, J. H., Kim, T. W., Byun, Y., Kwon, I. C., Kim, K. M. & Lee, J., 2016 Oct 11, In : Scientific Reports. 6, 35182.

Research output: Contribution to journalArticle

19 Citations (Scopus)

TSLP Down-Regulates S100A7 and ß-Defensin 2 Via the JAK2/STAT3-Dependent Mechanism

Lee, H., Ryu, W. I., Kim, H. J., Bae, H. C., Ryu, H. J., Shin, J. J., Song, K. H., Kim, T. W. & Son, S. W., 2016 Dec 1, In : Journal of Investigative Dermatology. 136, 12, p. 2427-2435 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2015

A polymeric conjugate foreignizing tumor cells for targeted immunotherapy in vivo

Lee, Y. H., Yoon, H. Y., Shin, J. M., Saravanakumar, G., Noh, K. H., Song, K. H., Jeon, J. H., Kim, D. W., Lee, K-M., Kim, K. M., Kwon, I. C., Park, J. H. & Kim, T. W., 2015 Feb 10, In : Journal of Controlled Release. 199, p. 98-105 8 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Apoptosis inhibitor 5 increases metastasis via Erk-mediated MMP expression

Song, K. H., Kim, S. H., Noh, K. H., Bae, H. C., Kim, J. H., Lee, H. J., Song, J., Kang, T. H., Kim, D. W., Oh, S. J., Jeon, J. H. & Kim, T. W., 2015, In : BMB Reports. 48, 6, p. 330-335 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Gain of HIF-1α under normoxia in cancer mediates immune adaptation through the AKT/ERK and VEGFA axes

Lee, Y. H., Bae, H. C., Noh, K. H., Song, K. H., Ye, S. K., Mao, C. P., Lee, K-M., Wu, T. C. & Kim, T. W., 2015 Mar 15, In : Clinical Cancer Research. 21, 6, p. 1438-1446 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

NANOG signaling promotes metastatic capability of immunoedited tumor cells

Lee, H. J., Noh, K. H., Lee, Y. H., Song, K. H., Oh, S. J., Kim, S. Y. & Kim, T. W., 2015 Apr 22, In : Clinical and Experimental Metastasis. 32, 5, p. 429-439 11 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Signal transducer and activator of transcription 3-mediated CD133 up-regulation contributes to promotion of hepatocellular carcinoma

Won, C., Kim, B. H., Yi, E. H., Choi, K. J., Kim, E. K., Jeong, J. M., Lee, J. H., Jang, J. J., Yoon, J. H., Jeong, W. I., Park, I. C., Kim, T. W., Bae, S. S., Factor, V. M., Ma, S., Thorgeirsson, S. S., Lee, Y. H. & Ye, S. K., 2015 Oct 1, In : Hepatology. 62, 4, p. 1160-1173 14 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Targeting stemness is an effective strategy to control EML4-ALK+ non-small cell lung cancer cells

Oh, S. J., Noh, K. H., Lee, Y. H., Hong, S. O., Song, K. H., Lee, H. J., Kim, S., Kim, T. M., Jeon, J. H., Seo, J. H., Kim, D. W. & Kim, T. W., 2015, In : Oncotarget. 6, 37, p. 40255-40267 13 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

The siRNA cocktail targeting interleukin 10 receptor and transforming growth factor-β receptor on dendritic cells potentiates tumour antigen-specific CD8<sup>+</sup> T cell immunity

Ahn, Y. H., Hong, S. O., Kim, J. H., Noh, K. H., Song, K. H., Lee, Y. H., Jeon, J. H., Kim, D. W., Seo, J. H. & Kim, T. W., 2015 Jul 1, In : Clinical and Experimental Immunology. 181, 1, p. 164-178 15 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
2014

API5 Confers Tumoral Immune Escape through FGF2- Dependent Cell Survival Pathway

Noh, K. H., Kim, S. H., Kim, J. H., Song, K. H., Lee, Y. H., Kang, T. H., Han, H. D., Sood, A. K., Ng, J., Kim, K., Sonn, C. H., Kumar, V., Yee, C., Lee, K-M. & Kim, T. W., 2014 Jul 1, In : Cancer Research. 74, 13, p. 3556-3566 11 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Apoptosis inhibitor-5 overexpression is associated with tumor progression and poor prognosis in patients with cervical cancer

Cho, H., Chung, J. Y., Song, K. H., Noh, K. H., Kim, B. W., Chung, E. J., Ylaya, K., Kim, J. H., Kim, T. W., Hewitt, S. M. & Kim, J. H., 2014 Jul 28, In : BMC Cancer. 14, 1, 545.

Research output: Contribution to journalArticle

15 Citations (Scopus)

GM-CSF-loaded chitosan hydrogel as an immunoadjuvant enhances antigen-specific immune responses with reduced toxicity

Noh, K. H., Park, Y. M., Kim, H. S., Kang, T. H., Song, K. H., Lee, Y. H., Byeon, Y., Jeon, H. N., Jung, I. D., Shin, B. C., Lee, K-M., Seong, S. Y., Han, H. D. & Kim, T. W., 2014 Oct 18, In : BMC Immunology. 15, 1, 41.

Research output: Contribution to journalArticle

11 Citations (Scopus)

HIF-1α expression as a protective strategy of HepG2 cells against fatty acid-induced toxicity

Yoo, W., Noh, K. H., Ahn, J. H., Yu, J. H., Seo, J. A., Kim, S. G., Choi, K. M., Baik, S-H., Choi, D. S., Kim, T. W., Kim, H. J. & Kim, N. H., 2014 Jan 1, In : Journal of Cellular Biochemistry. 115, 6, p. 1147-1158 12 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion

Mao, C. P., Wu, T. C., Song, K. H. & Kim, T. W., 2014 Jan 1, In : OncoImmunology. 3, 7, e947871.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Synaptonemal complex protein 3 is a prognostic marker in cervical cancer

Cho, H., Noh, K. H., Chung, J. Y., Takikita, M., Chung, E. J., Kim, B. W., Hewitt, S. M., Kim, T. W. & Kim, J. H., 2014 Jun 6, In : PLoS One. 9, 6, e98712.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Treatment of tumors with vitamin e suppresses myeloid derived suppressor cells and enhances CD8+ T cell-mediated antitumor effects

Kang, T. H., Knoff, J., Yeh, W. H., Yang, B., Wang, C., Kim, Y. S., Kim, T. W., Wu, T. C. & Hung, C. F., 2014 Jul 29, In : PLoS One. 9, 7, e103562.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2013

(ADP-ribose) polymerase 1 and AMP-activated protein kinase mediate progressive dopaminergic neuronal degeneration in a mouse model of Parkinson's disease

Kim, T. W., Cho, H. M., Choi, S. Y., Suguira, Y., Hayasaka, T., Setou, M., Koh, H. C., Mi Hwang, E., Park, J. Y., Kang, S. J., Kim, H. S., Kim, H. & Sun, W., 2013 Nov 1, In : Cell Death and Disease. 4, 11, e919.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Chemotherapy acts as an adjuvant to convert the tumor microenvironment into a highly permissive state for vaccination-induced antitumor immunity

Kang, T. H., Mao, C. P., Lee, S. Y., Chen, A., Lee, J. H., Kim, T. W., Alvarez, R. D., Roden, R. B. S., Pardoll, D., Hung, C. F. & Wu, T. C., 2013 Apr 15, In : Cancer Research. 73, 8, p. 2493-2504 12 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Synaptonemal complex protein 3 as a novel prognostic marker in early stage non-small cell lung cancer

Chung, J. Y., Kitano, H., Takikita, M., Cho, H., Noh, K. H., Kim, T. W., Ylaya, K., Hanaoka, J., Fukuoka, J. & Hewitt, S. M., 2013 Apr 1, In : Human Pathology. 44, 4, p. 472-479 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2012

Cancer vaccination drives nanog-dependent evolution of tumor cells toward an immune-resistant and stem-like phenotype

Noh, K. H., Lee, Y. H., Jeon, J. H., Kang, T. H., Mao, C. P., Wu, T. C. & Kim, T. W., 2012 Apr 1, In : Cancer Research. 72, 7, p. 1717-1727 11 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Cyclosporin A suppresses prostate cancer cell growth through CaMKKβ/AMPK-mediated inhibition of mTORC1 signaling

Lee, C. R., Chun, J. N., Kim, S. Y., Park, S., Kim, S. H., Park, E. J., Kim, I. S., Cho, N. H., Kim, I. G., So, I., Kim, T. W. & Jeon, J. H., 2012 Aug 15, In : Biochemical Pharmacology. 84, 4, p. 425-431 7 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Geraniol induces cooperative interaction of apoptosis and autophagy to elicit cell death in PC-3 prostate cancer cells

Kim, S. H., Park, E. J., Lee, C. R., Chun, J. N., Cho, N. H., Kim, I. G., Lee, S., Kim, T. W., Park, H. H., So, I. & Jeon, J. H., 2012 May 1, In : International Journal of Oncology. 40, 5, p. 1683-1690 8 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules

Han, B. G., Kim, K. H., Lee, S. J., Jeong, K. C., Cho, J. W., Noh, K. H., Kim, T. W., Kim, S. J., Yoon, H. J., Suh, S. W., Lee, S. & Lee, B. I., 2012 Mar 30, In : Journal of Biological Chemistry. 287, 14, p. 10727-10737 11 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Menthol induces cell-cycle arrest in PC-3 cells by down-regulating G2/M genes, including polo-like kinase 1

Kim, S. H., Lee, S., Piccolo, S. R., Allen-Brady, K., Park, E. J., Chun, J. N., Kim, T. W., Cho, N. H., Kim, I. G., So, I. & Jeon, J. H., 2012 Jun 8, In : Biochemical and Biophysical Research Communications. 422, 3, p. 436-441 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Nanog signaling in cancer promotes stem-like phenotype and immune evasion

Noh, K. H., Kim, B. W., Song, K. H., Cho, H., Lee, Y. H., Kim, J. H., Chung, J. Y., Kim, J. H., Hewitt, S. M., Seong, S. Y., Mao, C. P., Wu, T. C. & Kim, T. W., 2012 Nov 1, In : Journal of Clinical Investigation. 122, 11, p. 4077-4093 17 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)

Overexpression of Romo1 promotes production of reactive oxygen species and invasiveness of hepatic tumor cells

Chung, J. S., Park, S., Park, S. H., Park, E. R., Cha, P. H., Kim, B. Y., Chung, Y. M., Woo, S. R., Han, C. J., Kim, S. B., Suh, K. S., Jang, J. J., Lee, K., Choi, D. W., Lee, S., Lee, G. Y., Hahm, K. B., Shin, J. A., Kim, B. S., Noh, K. H. & 3 others, Kim, T. W., Lee, K. H. & Yoo, Y. D., 2012 Oct 1, In : Gastroenterology. 143, 4

Research output: Contribution to journalArticle

38 Citations (Scopus)
2011

Blocking the immunosuppressive axis with small interfering RNA targeting interleukin (IL)-10 receptor enhances dendritic cell-based vaccine potency

Kim, J. H., Kang, T. H., Noh, K. H., Bae, H. C., Ahn, Y. H., Lee, Y. H., Choi, E. Y., Chun, K. H., Lee, S. J. & Kim, T. W., 2011 Aug 1, In : Clinical and Experimental Immunology. 165, 2, p. 180-189 10 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

CD8+ T-cell Activation in Mice Injected with a Plasmid DNA Vaccine Encoding AMA-1 of the Reemerging Korean Plasmodium vivax

Kim, H. J., Jung, B. K., Lee, J. J., Pyo, K. H., Kim, T. Y., Choi, B. I., Kim, T. W., Hisaeda, H., Himeno, K., Shin, E. H. & Chai, J. Y., 2011 Mar 1, In : Korean Journal of Parasitology. 49, 1, p. 85-90 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Dissociation of progressive dopaminergic neuronal death and behavioral impairments by bax deletion in a mouse model of parkinson's diseases

Kim, T. W., Moon, Y., Kim, K., Lee, J. E., Koh, H. C., Rhyu, I. J., Kim, H. & Sun, W., 2011 Oct 17, In : PloS one. 6, 10, e25346.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Enhancement of DNA vaccine potency by antigen linkage to IFN-Iγ-inducible protein-10

Kang, T. H., Kim, K. W., Bae, H. C., Seong, S. Y. & Kim, T. W., 2011 Feb 1, In : International Journal of Cancer. 128, 3, p. 702-714 13 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Evidence for the spontaneous production but massive programmed cell death of new neurons in the subcallosal zone of the postnatal mouse brain

Kim, W. R., Chun, S. K., Kim, T. W., Kim, H., Ono, K., Takebayashi, H., Ikenaka, K., Oppenheim, R. W. & Sun, W., 2011 Feb 1, In : European Journal of Neuroscience. 33, 4, p. 599-611 13 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Geraniol inhibits prostate cancer growth by targeting cell cycle and apoptosis pathways

Kim, S. H., Bae, H. C., Park, E. J., Lee, C. R., Kim, B. J., Lee, S., Park, H. H., Kim, S. J., So, I., Kim, T. W. & Jeon, J. H., 2011 Apr 1, In : Biochemical and biophysical research communications. 407, 1, p. 129-134 6 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Induction of Per1 expression following an experimentally induced epilepsy in the mouse hippocampus

Eun, B., Kim, H. J., Kim, S. Y., Kim, T. W., Hong, S. T., Choi, K. M., Shim, J. K., Moon, Y., Son, G. H., Kim, K., Kim, H. & Sun, W., 2011 Jul 8, In : Neuroscience Letters. 498, 2, p. 110-113 4 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Morphine attenuates endothelial cell adhesion molecules induced by the supernatant of LPS-stimulated colon cancer cells

Min, T. J., Park, S. H., Ji, Y. H., Lee, Y. S., Kim, T. W., Kim, J. H., Kim, W. Y. & Park, Y. C., 2011 Jun 1, In : Journal of Korean medical science. 26, 6, p. 747-752 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Morphine postconditioning attenuates ICAM-1 expression on endothelial cells

Min, T. J., Kim, J. I., Kim, J. H., Noh, K. H., Kim, T. W., Kim, W. Y., Lee, Y. S. & Park, Y. C., 2011 Feb 1, In : Journal of Korean medical science. 26, 2, p. 290-296 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Spontaneous reactive astrogliosis in the dentate gyrus of bax-deficient mice

Kim, T. W., Kim, H. & Sun, W., 2011 Apr 1, In : Molecules and Cells. 31, 4, p. 379-383 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2010

Ectopic expression of X-linked lymphocyte-regulated protein pM1 renders tumor cells resistant to antitumor immunity

Kang, T. H., Noh, K. H., Kim, J. H., Bae, H. C., Lin, K. Y., Monie, A., Pai, S. I., Hung, C. F., Wu, T. C. & Kim, T. W., 2010 Apr 15, In : Cancer Research. 70, 8, p. 3062-3070 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)