β-Isocyanoalanine as an IR probe: comparison of vibrational dynamics between isonitrile and nitrile-derivatized IR probes

Michał Maj, Changwoo Ahn, Dorota Kossowska, Kwanghee Park, Kyungwon Kwak, Hogyu Han, Minhaeng Cho

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

An infrared (IR) probe based on isonitrile (NC)-derivatized alanine 1 was synthesized and the vibrational properties of its NC stretching mode were investigated using FTIR and femtosecond IR pump-probe spectroscopy. It is found that the NC stretching mode is very sensitive to the hydrogen-bonding ability of solvent molecules. Moreover, its transition dipole strength is larger than that of nitrile (CN) in nitrile-derivatized IR probe 2. The vibrational lifetime of the NC stretching mode is found to be 5.5 ± 0.2 ps in both D<inf>2</inf>O and DMF solvents, which is several times longer than that of the azido (N<inf>3</inf>) stretching mode in azido-derivatized IR probe 3. Altogether these properties suggest that the NC group can be a very promising sensing moiety of IR probes for studying the solvation structure and dynamics of biomolecules. This journal is

Original languageEnglish
Pages (from-to)11770-11778
Number of pages9
JournalPhysical Chemistry Chemical Physics
Volume17
Issue number17
DOIs
Publication statusPublished - 2015 May 7

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Physics and Astronomy(all)

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