βig-h3 supports keratinocyte adhesion, migration, and proliferation through α3β1 integrin

Jong Sup Bae, Suk Hee Lee, Jung Eun Kim, Je Yong Choi, Rang Woon Park, Jae Yong Park, Hyun Sook Park, Young Sook Sohn, Dong Sin Lee, Eunhee Bae Lee, In San Kim

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

βig-h3 is an extracellular matrix protein and its expression is highly induced by TGF-β and it has also been suggested to play important roles in skin wound healing. In this paper, we demonstrate that βig-h3 is present in the papillary layer of dermis and synthesized in the basal keratinocytes in vivo and its expression is induced by TGF-β in normal human keratinocytes (NHEK) and HaCaT cells. βig-h3 mediates not only adhesion and spreading of keratinocytes but also supports migration and proliferation. These activities are mediated through interacting with α3β1 integrin. Previously identified two α3β1 integrin-interacting motifs of βig-h3, EPDIM, and NKDIL, are responsible for these activities. The results suggest that βig-h3 may regulate keratinocyte functions in normal skin and potentially during wound-healing process.

Original languageEnglish
Pages (from-to)940-948
Number of pages9
JournalBiochemical and biophysical research communications
Volume294
Issue number5
DOIs
Publication statusPublished - 2002 Jun 28

Keywords

  • Cell adhesion
  • Keratinocyte
  • Migration
  • TGF-β
  • Wound healing
  • α3β1 Integrin
  • βig-h3

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Bae, J. S., Lee, S. H., Kim, J. E., Choi, J. Y., Park, R. W., Yong Park, J., Park, H. S., Sohn, Y. S., Lee, D. S., Bae Lee, E., & Kim, I. S. (2002). βig-h3 supports keratinocyte adhesion, migration, and proliferation through α3β1 integrin. Biochemical and biophysical research communications, 294(5), 940-948. https://doi.org/10.1016/S0006-291X(02)00576-4