ΔNp63 protein expression in uterine cervical and endometrial cancers

Zhenhua Lin, Mingzhu Liu, Zhuhu Li, Changheon Kim, Eungseok Lee, Insun Kim

    Research output: Contribution to journalArticlepeer-review

    30 Citations (Scopus)

    Abstract

    Purpose: To investigate the significance of p63 expression in uterine cervical and endometrial cancers. Materials and methods: ΔNp63 protein expression was studied in a variety of 127 cases of uterine cervical lesions (20 non-neoplastic cervices, 43 cervical intraepithelial neoplasia [CIN], 54 squamous cell carcinomas (SCCs), 40 adenocarcinomas, and 13 other histologic types) and 30 endometrioid type of endometrial adenocarcinomas by using immunohistochemistry. One SCC cell line (ME-180) and one adenocarcinoma cell line (HeLa) were also included. Results: In uterine cervix, the expression of ΔNp63 was increased with progression of CIN, and positive in all SCCs, transitional cell carcinomas, and adenoid basal carcinoma, but negative in all adenocarcinomas. Adenosquamous cell carcinoma and mixed neuroendocrine and squamous cell carcinoma were positive in squamous component, but not in adenocarcinoma and neuroendocrine carcinoma components. ME-180 cell line was positive, whereas HeLa cell line was negative. Endometrioid type of endometrial adenocarcinomas showed a positive staining in glandular (26.7%) and squamous component. Conclusions: Immunohistochemical staining for ΔNp63 is a powerful marker for squamous differentiation and useful in exclusion of glandular and neuroendocrine differentiation in uterine cervical cancers, but not always in endometrial cancers.

    Original languageEnglish
    Pages (from-to)811-816
    Number of pages6
    JournalJournal of Cancer Research and Clinical Oncology
    Volume132
    Issue number12
    DOIs
    Publication statusPublished - 2006 Dec

    Keywords

    • Endometrial cancer
    • Uterine cervical cancer
    • ΔNp63

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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