Abstract
Tsc-protected ε-amino acids, bicyclo[3.3.0]octane-5-amino-1-carboxylic acids (1), ready to use in the solid-phase synthesis, are prepared from 4,4-diethylcarboxylic bicyclo[3.3.0]oct-2-enone (3), which is available in bulk from 2 through the catalytic Pauson-Khand reaction.
| Original language | English |
|---|---|
| Pages (from-to) | 7389-7393 |
| Number of pages | 5 |
| Journal | Tetrahedron Letters |
| Volume | 47 |
| Issue number | 41 |
| DOIs | |
| Publication status | Published - 2006 Oct 9 |
Keywords
- Bicyclic amino acid
- Pauson-Khand reaction
- Solid phase synthesis
- Tsc amine-protecting group
- Unnatural amino acid
- ε-Amino acid
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Cite this
Yeo, S. J., Jeong, K. S., Han, H., Kim, J., & Jeong, N. (2006). ε-Amino acids based on bicyclic skeleton: bicyclo[3.3.0]octane-5-amino-1-carboxylic acids. Tetrahedron Letters, 47(41), 7389-7393. https://doi.org/10.1016/j.tetlet.2006.07.137