14-3-3η inhibits chondrogenic differentiation of ATDC5 cell

Hee Eun Yoon, Ki Soon Kim, Ick Young Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

It was previously shown that 14-3-3η is overexpressed in the synovial fluid of patients with joint inflammation, which is often associated with growth failure. In this study, we investigated the role of 14-3-3η in chondrogenesis using ATDC5 cells. Upon treatment with TNF-α, cells overexpressed 14-3-3η with inhibition of chondrogenesis. Chondrogenesis was also inhibited by overexpression of 14-3-3η without TNF-α treatment, whereas silencing of 14-3-3η promoted chondrogenic differentiation. Further, G1 phase arrest was inhibited by overexpression of 14-3-3η. In summary, we suggest that 14-3-3η plays a regulatory role in chondrogenic differentiation.

Original languageEnglish
Pages (from-to)59-63
Number of pages5
JournalBiochemical and biophysical research communications
Volume406
Issue number1
DOIs
Publication statusPublished - 2011 Mar 4

Keywords

  • 14-3-3η
  • ATDC5 cells
  • Chondrogenesis
  • Joint inflammation

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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