196G/A of the Brain-Derived Neurotrophic Factor Gene Polymorphisms Predicts Suicidal Behavior in Schizophrenia Patients

Eun Jeong Kim, Yong Ku Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective Brain-derived neurotrophic factor (BDNF) has possible neurobiologic impact on etiology of schizophrenia. We hypothesized that the specific allele or the genotype such as two single nucleotide polymorphisms (SNPs), 196G/A (rs6265), 11757G/C(rs16917204) is associated with schizophrenia or its clinical features. Methods 241 normal controls and 157 schizophrenia patients are included. The differences in allele or genotype distribution for the patients and normal controls were analyzed. We also analyzed clinical variables among patients. Results We found no significant difference in genotype or allele distributions of two studied SNPs between the patient group and the control group. However, history of suicide attempt was relatively higher in patients with genotype with A allele, compared to patients with genotype G/G for 196G/A (p-value=0.045). Conclusion Our results suggest that it is possible to use BDNF gene allele and genotype as a predictor for suicide attempt in schizophrenia patients. It can help manage the schizophrenia patients regarding suicidal behavior and furthermore, mortality.

Original languageEnglish
Pages (from-to)733-738
Number of pages6
JournalPsychiatry Investigation
Volume15
Issue number7
DOIs
Publication statusPublished - 2018 Jul 1

Fingerprint

Brain-Derived Neurotrophic Factor
Schizophrenia
Genotype
Alleles
Genes
Suicide
Single Nucleotide Polymorphism
Normal Distribution
Control Groups
Mortality

Keywords

  • Brain-derived neurotrophic factor
  • Polymorphisms
  • Schizophrenia
  • Suicide

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

196G/A of the Brain-Derived Neurotrophic Factor Gene Polymorphisms Predicts Suicidal Behavior in Schizophrenia Patients. / Kim, Eun Jeong; Kim, Yong Ku.

In: Psychiatry Investigation, Vol. 15, No. 7, 01.07.2018, p. 733-738.

Research output: Contribution to journalArticle

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N2 - Objective Brain-derived neurotrophic factor (BDNF) has possible neurobiologic impact on etiology of schizophrenia. We hypothesized that the specific allele or the genotype such as two single nucleotide polymorphisms (SNPs), 196G/A (rs6265), 11757G/C(rs16917204) is associated with schizophrenia or its clinical features. Methods 241 normal controls and 157 schizophrenia patients are included. The differences in allele or genotype distribution for the patients and normal controls were analyzed. We also analyzed clinical variables among patients. Results We found no significant difference in genotype or allele distributions of two studied SNPs between the patient group and the control group. However, history of suicide attempt was relatively higher in patients with genotype with A allele, compared to patients with genotype G/G for 196G/A (p-value=0.045). Conclusion Our results suggest that it is possible to use BDNF gene allele and genotype as a predictor for suicide attempt in schizophrenia patients. It can help manage the schizophrenia patients regarding suicidal behavior and furthermore, mortality.

AB - Objective Brain-derived neurotrophic factor (BDNF) has possible neurobiologic impact on etiology of schizophrenia. We hypothesized that the specific allele or the genotype such as two single nucleotide polymorphisms (SNPs), 196G/A (rs6265), 11757G/C(rs16917204) is associated with schizophrenia or its clinical features. Methods 241 normal controls and 157 schizophrenia patients are included. The differences in allele or genotype distribution for the patients and normal controls were analyzed. We also analyzed clinical variables among patients. Results We found no significant difference in genotype or allele distributions of two studied SNPs between the patient group and the control group. However, history of suicide attempt was relatively higher in patients with genotype with A allele, compared to patients with genotype G/G for 196G/A (p-value=0.045). Conclusion Our results suggest that it is possible to use BDNF gene allele and genotype as a predictor for suicide attempt in schizophrenia patients. It can help manage the schizophrenia patients regarding suicidal behavior and furthermore, mortality.

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