2-phenoxychromones and prenylflavonoids from Epimedium koreanum and their inhibitory effects on LPS-induced nitric oxide and interleukin-1β production

Qinghao Jin, Chul Lee, Jin Woo Lee, Eung Tae Yeon, Dongho Lee, Sang Bae Han, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Two new 2-phenoxychromones 1 and 2 and two prenylflavonoids 3 and 4 along with 12 known compounds (5-16) were isolated from the CH2Cl 2-soluble fraction of a methanol extract of Epimedium koreanum. Compounds 1, 4, 6, 7, 9, 10, 12, and 15 exhibit inhibitory effects on nitric oxide production with IC50 values ranging from 16.8 to 49.3 μM. Compounds 1, 4, 7, and 12 also showed inhibitory effects on interleukin-1β production with IC50 values ranging from 8.6 to 38.9 μM in RAW 264.7 macrophages.

Original languageEnglish
Pages (from-to)1724-1728
Number of pages5
JournalJournal of Natural Products
Volume77
Issue number7
DOIs
Publication statusPublished - 2014 Jul 25

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Epimedium
Interleukin-1
Inhibitory Concentration 50
Nitric Oxide
Macrophages
Methanol

ASJC Scopus subject areas

  • Molecular Medicine
  • Complementary and alternative medicine
  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Analytical Chemistry
  • Organic Chemistry

Cite this

2-phenoxychromones and prenylflavonoids from Epimedium koreanum and their inhibitory effects on LPS-induced nitric oxide and interleukin-1β production. / Jin, Qinghao; Lee, Chul; Lee, Jin Woo; Yeon, Eung Tae; Lee, Dongho; Han, Sang Bae; Hong, Jin Tae; Kim, Youngsoo; Lee, Mi Kyeong; Hwang, Bang Yeon.

In: Journal of Natural Products, Vol. 77, No. 7, 25.07.2014, p. 1724-1728.

Research output: Contribution to journalArticle

Jin, Qinghao ; Lee, Chul ; Lee, Jin Woo ; Yeon, Eung Tae ; Lee, Dongho ; Han, Sang Bae ; Hong, Jin Tae ; Kim, Youngsoo ; Lee, Mi Kyeong ; Hwang, Bang Yeon. / 2-phenoxychromones and prenylflavonoids from Epimedium koreanum and their inhibitory effects on LPS-induced nitric oxide and interleukin-1β production. In: Journal of Natural Products. 2014 ; Vol. 77, No. 7. pp. 1724-1728.
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AU - Yeon, Eung Tae

AU - Lee, Dongho

AU - Han, Sang Bae

AU - Hong, Jin Tae

AU - Kim, Youngsoo

AU - Lee, Mi Kyeong

AU - Hwang, Bang Yeon

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