2-phenoxychromones and prenylflavonoids from Epimedium koreanum and their inhibitory effects on LPS-induced nitric oxide and interleukin-1β production

Qinghao Jin, Chul Lee, Jin Woo Lee, Eung Tae Yeon, Dongho Lee, Sang Bae Han, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Two new 2-phenoxychromones 1 and 2 and two prenylflavonoids 3 and 4 along with 12 known compounds (5-16) were isolated from the CH2Cl 2-soluble fraction of a methanol extract of Epimedium koreanum. Compounds 1, 4, 6, 7, 9, 10, 12, and 15 exhibit inhibitory effects on nitric oxide production with IC50 values ranging from 16.8 to 49.3 μM. Compounds 1, 4, 7, and 12 also showed inhibitory effects on interleukin-1β production with IC50 values ranging from 8.6 to 38.9 μM in RAW 264.7 macrophages.

Original languageEnglish
Pages (from-to)1724-1728
Number of pages5
JournalJournal of Natural Products
Volume77
Issue number7
DOIs
Publication statusPublished - 2014 Jul 25

ASJC Scopus subject areas

  • Molecular Medicine
  • Complementary and alternative medicine
  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Analytical Chemistry
  • Organic Chemistry

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