Abstract
The microfluidic epithelial models to mimic microenvironment physiologically has potential to be a useful tool for drug screening and pathophysiologic researches. Although a number of researches have demonstrated in-vitro nasal epithelial models, only few studies showed complicated nasal mucous membrane models. Here, we introduced a new 3-dimmensional (3D) in-vitro human nasal mucosa model with glands by optimizing culture conditions such as media, air-interfacing, hydrogels and type of cells in micro-scale. The similarity between in-vivo nasal mucous membrane and our invitro model suggest its utilization as a reliable research model for nasal disease models.
| Original language | English |
|---|---|
| Title of host publication | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 503-504 |
| Number of pages | 2 |
| ISBN (Electronic) | 9780979806490 |
| Publication status | Published - 2016 |
| Event | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland Duration: 2016 Oct 9 → 2016 Oct 13 |
Other
| Other | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 |
|---|---|
| Country | Ireland |
| City | Dublin |
| Period | 16/10/9 → 16/10/13 |
Keywords
- 3-dimensional
- Glands
- Nasal epithelial model
- Nasal mucosa
ASJC Scopus subject areas
- Control and Systems Engineering