Abstract
The microfluidic epithelial models to mimic microenvironment physiologically has potential to be a useful tool for drug screening and pathophysiologic researches. Although a number of researches have demonstrated in-vitro nasal epithelial models, only few studies showed complicated nasal mucous membrane models. Here, we introduced a new 3-dimmensional (3D) in-vitro human nasal mucosa model with glands by optimizing culture conditions such as media, air-interfacing, hydrogels and type of cells in micro-scale. The similarity between in-vivo nasal mucous membrane and our invitro model suggest its utilization as a reliable research model for nasal disease models.
| Original language | English |
|---|---|
| Title of host publication | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 503-504 |
| Number of pages | 2 |
| ISBN (Electronic) | 9780979806490 |
| Publication status | Published - 2016 |
| Event | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland Duration: 2016 Oct 9 → 2016 Oct 13 |
Other
| Other | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 |
|---|---|
| Country | Ireland |
| City | Dublin |
| Period | 16/10/9 → 16/10/13 |
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Keywords
- 3-dimensional
- Glands
- Nasal epithelial model
- Nasal mucosa
ASJC Scopus subject areas
- Control and Systems Engineering
Cite this
3-dimensional in-vitro human nasal mucous membrane with glands. / Na, Kyuhwan; Lee, Mingyu; Shin, Hyun Woo; Chung, Seok.
20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, 2016. p. 503-504.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - 3-dimensional in-vitro human nasal mucous membrane with glands
AU - Na, Kyuhwan
AU - Lee, Mingyu
AU - Shin, Hyun Woo
AU - Chung, Seok
PY - 2016
Y1 - 2016
N2 - The microfluidic epithelial models to mimic microenvironment physiologically has potential to be a useful tool for drug screening and pathophysiologic researches. Although a number of researches have demonstrated in-vitro nasal epithelial models, only few studies showed complicated nasal mucous membrane models. Here, we introduced a new 3-dimmensional (3D) in-vitro human nasal mucosa model with glands by optimizing culture conditions such as media, air-interfacing, hydrogels and type of cells in micro-scale. The similarity between in-vivo nasal mucous membrane and our invitro model suggest its utilization as a reliable research model for nasal disease models.
AB - The microfluidic epithelial models to mimic microenvironment physiologically has potential to be a useful tool for drug screening and pathophysiologic researches. Although a number of researches have demonstrated in-vitro nasal epithelial models, only few studies showed complicated nasal mucous membrane models. Here, we introduced a new 3-dimmensional (3D) in-vitro human nasal mucosa model with glands by optimizing culture conditions such as media, air-interfacing, hydrogels and type of cells in micro-scale. The similarity between in-vivo nasal mucous membrane and our invitro model suggest its utilization as a reliable research model for nasal disease models.
KW - 3-dimensional
KW - Glands
KW - Nasal epithelial model
KW - Nasal mucosa
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UR - http://www.scopus.com/inward/citedby.url?scp=85014234370&partnerID=8YFLogxK
M3 - Conference contribution
SP - 503
EP - 504
BT - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
PB - Chemical and Biological Microsystems Society
ER -