TY - GEN
T1 - 3-dimensional in-vitro human nasal mucous membrane with glands
AU - Na, Kyuhwan
AU - Lee, Mingyu
AU - Shin, Hyun Woo
AU - Chung, Seok
N1 - Funding Information:
This work was supported by the Human Resources Development of the Korea Institute of Energy Technology Evaluation and Planning(KETEP) grant funded by the Korea government Ministry of Trade, Industry & Energy(No. 20144010200770) This work was supported by BioNano Health-Guard Research Center funded by the Ministry of Science, ICT & Future Planning (MSIP) of Korea as Global Frontier Project (Grant Number H-GUARD2014M3A6B2060524).
PY - 2016
Y1 - 2016
N2 - The microfluidic epithelial models to mimic microenvironment physiologically has potential to be a useful tool for drug screening and pathophysiologic researches. Although a number of researches have demonstrated in-vitro nasal epithelial models, only few studies showed complicated nasal mucous membrane models. Here, we introduced a new 3-dimmensional (3D) in-vitro human nasal mucosa model with glands by optimizing culture conditions such as media, air-interfacing, hydrogels and type of cells in micro-scale. The similarity between in-vivo nasal mucous membrane and our invitro model suggest its utilization as a reliable research model for nasal disease models.
AB - The microfluidic epithelial models to mimic microenvironment physiologically has potential to be a useful tool for drug screening and pathophysiologic researches. Although a number of researches have demonstrated in-vitro nasal epithelial models, only few studies showed complicated nasal mucous membrane models. Here, we introduced a new 3-dimmensional (3D) in-vitro human nasal mucosa model with glands by optimizing culture conditions such as media, air-interfacing, hydrogels and type of cells in micro-scale. The similarity between in-vivo nasal mucous membrane and our invitro model suggest its utilization as a reliable research model for nasal disease models.
KW - 3-dimensional
KW - Glands
KW - Nasal epithelial model
KW - Nasal mucosa
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M3 - Conference contribution
AN - SCOPUS:85014234370
T3 - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
SP - 503
EP - 504
BT - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
PB - Chemical and Biological Microsystems Society
T2 - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
Y2 - 9 October 2016 through 13 October 2016
ER -
