TY - GEN
T1 - 3-Dimensional in vitro model for studying monocyte-induced pre-metastatic cancer invasion
AU - Kim, Hyunho
AU - Chung, Hyewon
AU - Shin, Yoojin
AU - Choi, Dong Hee
AU - Chung, Seok
AU - Seok, Seung Hyeok
N1 - Funding Information:
This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI14C3418) This research was supported by the Pioneer Research Center Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT & Future Planning (NRF-2015M3C1A3002152).
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016
Y1 - 2016
N2 - Cancer cell needs supportive microenvironments to survive in metastatic region. During cancer metastasis, some of macrophages make pre-metastatic niche in which circulating tumor cells are induced to extravasate. They secret various cytokines, matrix metalloproteinase (MMPs) and soluble factors promoting extracellular matrix (ECM) degradation [1]. However, the explanation regarding how monocyte (macrophage precursor)/macrophage work in pre-metastatic niche has not been clearly unveiled. We developed a 3D in vitro microfluidic chip containing ECM scaffold. This system provides physiological microenvironment resembling in vivo.
AB - Cancer cell needs supportive microenvironments to survive in metastatic region. During cancer metastasis, some of macrophages make pre-metastatic niche in which circulating tumor cells are induced to extravasate. They secret various cytokines, matrix metalloproteinase (MMPs) and soluble factors promoting extracellular matrix (ECM) degradation [1]. However, the explanation regarding how monocyte (macrophage precursor)/macrophage work in pre-metastatic niche has not been clearly unveiled. We developed a 3D in vitro microfluidic chip containing ECM scaffold. This system provides physiological microenvironment resembling in vivo.
KW - 3D cancer invasion
KW - Microfluidic device
KW - Monocytes
KW - Pre-metastatic niche
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M3 - Conference contribution
AN - SCOPUS:85014262545
T3 - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
SP - 77
EP - 78
BT - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
PB - Chemical and Biological Microsystems Society
T2 - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
Y2 - 9 October 2016 through 13 October 2016
ER -
