3-Dimensional in vitro model for studying monocyte-induced pre-metastatic cancer invasion

Hyunho Kim, Hyewon Chung, Yoojin Shin, Dong Hee Choi, Seok Chung, Seung Hyeok Seok

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Cancer cell needs supportive microenvironments to survive in metastatic region. During cancer metastasis, some of macrophages make pre-metastatic niche in which circulating tumor cells are induced to extravasate. They secret various cytokines, matrix metalloproteinase (MMPs) and soluble factors promoting extracellular matrix (ECM) degradation [1]. However, the explanation regarding how monocyte (macrophage precursor)/macrophage work in pre-metastatic niche has not been clearly unveiled. We developed a 3D in vitro microfluidic chip containing ECM scaffold. This system provides physiological microenvironment resembling in vivo.

Original languageEnglish
Title of host publication20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
PublisherChemical and Biological Microsystems Society
Pages77-78
Number of pages2
ISBN (Electronic)9780979806490
Publication statusPublished - 2016
Event20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland
Duration: 2016 Oct 92016 Oct 13

Other

Other20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
CountryIreland
CityDublin
Period16/10/916/10/13

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Keywords

  • 3D cancer invasion
  • Microfluidic device
  • Monocytes
  • Pre-metastatic niche

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Kim, H., Chung, H., Shin, Y., Choi, D. H., Chung, S., & Seok, S. H. (2016). 3-Dimensional in vitro model for studying monocyte-induced pre-metastatic cancer invasion. In 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 (pp. 77-78). Chemical and Biological Microsystems Society.