3-Dimensional in vitro model for studying monocyte-induced pre-metastatic cancer invasion

Hyunho Kim; Hyewon Chung; Yoojin Shin; Dong Hee Choi; Seok Chung; Seung Hyeok Seok

3-Dimensional in vitro model for studying monocyte-induced pre-metastatic cancer invasion

Hyunho Kim, Hyewon Chung, Yoojin Shin, Dong Hee Choi, Seok Chung, Seung Hyeok Seok

Department of Mechanical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Cancer cell needs supportive microenvironments to survive in metastatic region. During cancer metastasis, some of macrophages make pre-metastatic niche in which circulating tumor cells are induced to extravasate. They secret various cytokines, matrix metalloproteinase (MMPs) and soluble factors promoting extracellular matrix (ECM) degradation [1]. However, the explanation regarding how monocyte (macrophage precursor)/macrophage work in pre-metastatic niche has not been clearly unveiled. We developed a 3D in vitro microfluidic chip containing ECM scaffold. This system provides physiological microenvironment resembling in vivo.

Original language	English
Title of host publication	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
Publisher	Chemical and Biological Microsystems Society
Pages	77-78
Number of pages	2
ISBN (Electronic)	9780979806490
Publication status	Published - 2016
Event	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland Duration: 2016 Oct 9 → 2016 Oct 13

Other

Other	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
Country	Ireland
City	Dublin
Period	16/10/9 → 16/10/13

Keywords

3D cancer invasion
Microfluidic device
Monocytes
Pre-metastatic niche

ASJC Scopus subject areas

Control and Systems Engineering

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3-Dimensional in vitro model for studying monocyte-induced pre-metastatic cancer invasion. / Kim, Hyunho; Chung, Hyewon; Shin, Yoojin; Choi, Dong Hee; Chung, Seok; Seok, Seung Hyeok.

20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, 2016. p. 77-78.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Kim, H, Chung, H, Shin, Y, Choi, DH, Chung, S & Seok, SH 2016, 3-Dimensional in vitro model for studying monocyte-induced pre-metastatic cancer invasion. in 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, pp. 77-78, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016, Dublin, Ireland, 16/10/9.

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abstract = "Cancer cell needs supportive microenvironments to survive in metastatic region. During cancer metastasis, some of macrophages make pre-metastatic niche in which circulating tumor cells are induced to extravasate. They secret various cytokines, matrix metalloproteinase (MMPs) and soluble factors promoting extracellular matrix (ECM) degradation [1]. However, the explanation regarding how monocyte (macrophage precursor)/macrophage work in pre-metastatic niche has not been clearly unveiled. We developed a 3D in vitro microfluidic chip containing ECM scaffold. This system provides physiological microenvironment resembling in vivo.",

keywords = "3D cancer invasion, Microfluidic device, Monocytes, Pre-metastatic niche",

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booktitle = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016",

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AU - Seok, Seung Hyeok

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AB - Cancer cell needs supportive microenvironments to survive in metastatic region. During cancer metastasis, some of macrophages make pre-metastatic niche in which circulating tumor cells are induced to extravasate. They secret various cytokines, matrix metalloproteinase (MMPs) and soluble factors promoting extracellular matrix (ECM) degradation [1]. However, the explanation regarding how monocyte (macrophage precursor)/macrophage work in pre-metastatic niche has not been clearly unveiled. We developed a 3D in vitro microfluidic chip containing ECM scaffold. This system provides physiological microenvironment resembling in vivo.

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KW - Microfluidic device

KW - Monocytes

KW - Pre-metastatic niche

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