3-Dimensional in vitro model for studying monocyte-induced pre-metastatic cancer invasion

Hyunho Kim; Hyewon Chung; Yoojin Shin; Dong Hee Choi; Seok Chung; Seung Hyeok Seok

3-Dimensional in vitro model for studying monocyte-induced pre-metastatic cancer invasion

Hyunho Kim, Hyewon Chung, Yoojin Shin, Dong Hee Choi, Seok Chung, Seung Hyeok Seok

School of Mechanical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Cancer cell needs supportive microenvironments to survive in metastatic region. During cancer metastasis, some of macrophages make pre-metastatic niche in which circulating tumor cells are induced to extravasate. They secret various cytokines, matrix metalloproteinase (MMPs) and soluble factors promoting extracellular matrix (ECM) degradation [1]. However, the explanation regarding how monocyte (macrophage precursor)/macrophage work in pre-metastatic niche has not been clearly unveiled. We developed a 3D in vitro microfluidic chip containing ECM scaffold. This system provides physiological microenvironment resembling in vivo.

Original language	English
Title of host publication	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
Publisher	Chemical and Biological Microsystems Society
Pages	77-78
Number of pages	2
ISBN (Electronic)	9780979806490
Publication status	Published - 2016
Event	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland Duration: 2016 Oct 9 → 2016 Oct 13

Publication series

Name	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

Other

Other	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
Country	Ireland
City	Dublin
Period	16/10/9 → 16/10/13

Keywords

3D cancer invasion
Microfluidic device
Monocytes
Pre-metastatic niche

ASJC Scopus subject areas

Control and Systems Engineering

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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Kim, H., Chung, H., Shin, Y., Choi, D. H., Chung, S., & Seok, S. H. (2016). 3-Dimensional in vitro model for studying monocyte-induced pre-metastatic cancer invasion. In 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 (pp. 77-78). (20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016). Chemical and Biological Microsystems Society.

3-Dimensional in vitro model for studying monocyte-induced pre-metastatic cancer invasion. / Kim, Hyunho; Chung, Hyewon; Shin, Yoojin; Choi, Dong Hee; Chung, Seok; Seok, Seung Hyeok.

20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, 2016. p. 77-78 (20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Kim, H, Chung, H, Shin, Y, Choi, DH, Chung, S & Seok, SH 2016, 3-Dimensional in vitro model for studying monocyte-induced pre-metastatic cancer invasion. in 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016, Chemical and Biological Microsystems Society, pp. 77-78, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016, Dublin, Ireland, 16/10/9.

Kim H, Chung H, Shin Y, Choi DH, Chung S, Seok SH. 3-Dimensional in vitro model for studying monocyte-induced pre-metastatic cancer invasion. In 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society. 2016. p. 77-78. (20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016).

Kim, Hyunho ; Chung, Hyewon ; Shin, Yoojin ; Choi, Dong Hee ; Chung, Seok ; Seok, Seung Hyeok. / 3-Dimensional in vitro model for studying monocyte-induced pre-metastatic cancer invasion. 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, 2016. pp. 77-78 (20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016).

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title = "3-Dimensional in vitro model for studying monocyte-induced pre-metastatic cancer invasion",

abstract = "Cancer cell needs supportive microenvironments to survive in metastatic region. During cancer metastasis, some of macrophages make pre-metastatic niche in which circulating tumor cells are induced to extravasate. They secret various cytokines, matrix metalloproteinase (MMPs) and soluble factors promoting extracellular matrix (ECM) degradation [1]. However, the explanation regarding how monocyte (macrophage precursor)/macrophage work in pre-metastatic niche has not been clearly unveiled. We developed a 3D in vitro microfluidic chip containing ECM scaffold. This system provides physiological microenvironment resembling in vivo.",

keywords = "3D cancer invasion, Microfluidic device, Monocytes, Pre-metastatic niche",

author = "Hyunho Kim and Hyewon Chung and Yoojin Shin and Choi, {Dong Hee} and Seok Chung and Seok, {Seung Hyeok}",

note = "Funding Information: This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI14C3418) This research was supported by the Pioneer Research Center Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT & Future Planning (NRF-2015M3C1A3002152). Copyright: Copyright 2017 Elsevier B.V., All rights reserved.; 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 ; Conference date: 09-10-2016 Through 13-10-2016",

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AU - Chung, Seok

AU - Seok, Seung Hyeok

N1 - Funding Information: This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI14C3418) This research was supported by the Pioneer Research Center Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT & Future Planning (NRF-2015M3C1A3002152). Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2016

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N2 - Cancer cell needs supportive microenvironments to survive in metastatic region. During cancer metastasis, some of macrophages make pre-metastatic niche in which circulating tumor cells are induced to extravasate. They secret various cytokines, matrix metalloproteinase (MMPs) and soluble factors promoting extracellular matrix (ECM) degradation [1]. However, the explanation regarding how monocyte (macrophage precursor)/macrophage work in pre-metastatic niche has not been clearly unveiled. We developed a 3D in vitro microfluidic chip containing ECM scaffold. This system provides physiological microenvironment resembling in vivo.

AB - Cancer cell needs supportive microenvironments to survive in metastatic region. During cancer metastasis, some of macrophages make pre-metastatic niche in which circulating tumor cells are induced to extravasate. They secret various cytokines, matrix metalloproteinase (MMPs) and soluble factors promoting extracellular matrix (ECM) degradation [1]. However, the explanation regarding how monocyte (macrophage precursor)/macrophage work in pre-metastatic niche has not been clearly unveiled. We developed a 3D in vitro microfluidic chip containing ECM scaffold. This system provides physiological microenvironment resembling in vivo.

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KW - Microfluidic device

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BT - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

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ER -

3-Dimensional in vitro model for studying monocyte-induced pre-metastatic cancer invasion

Abstract

Publication series

Other

Keywords

ASJC Scopus subject areas

UN SDGs

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Cite this