Abstract
Cancer cell needs supportive microenvironments to survive in metastatic region. During cancer metastasis, some of macrophages make pre-metastatic niche in which circulating tumor cells are induced to extravasate. They secret various cytokines, matrix metalloproteinase (MMPs) and soluble factors promoting extracellular matrix (ECM) degradation [1]. However, the explanation regarding how monocyte (macrophage precursor)/macrophage work in pre-metastatic niche has not been clearly unveiled. We developed a 3D in vitro microfluidic chip containing ECM scaffold. This system provides physiological microenvironment resembling in vivo.
| Original language | English |
|---|---|
| Title of host publication | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 77-78 |
| Number of pages | 2 |
| ISBN (Electronic) | 9780979806490 |
| Publication status | Published - 2016 |
| Event | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland Duration: 2016 Oct 9 → 2016 Oct 13 |
Other
| Other | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 |
|---|---|
| Country | Ireland |
| City | Dublin |
| Period | 16/10/9 → 16/10/13 |
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Keywords
- 3D cancer invasion
- Microfluidic device
- Monocytes
- Pre-metastatic niche
ASJC Scopus subject areas
- Control and Systems Engineering
Cite this
3-Dimensional in vitro model for studying monocyte-induced pre-metastatic cancer invasion. / Kim, Hyunho; Chung, Hyewon; Shin, Yoojin; Choi, Dong Hee; Chung, Seok; Seok, Seung Hyeok.
20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, 2016. p. 77-78.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - 3-Dimensional in vitro model for studying monocyte-induced pre-metastatic cancer invasion
AU - Kim, Hyunho
AU - Chung, Hyewon
AU - Shin, Yoojin
AU - Choi, Dong Hee
AU - Chung, Seok
AU - Seok, Seung Hyeok
PY - 2016
Y1 - 2016
N2 - Cancer cell needs supportive microenvironments to survive in metastatic region. During cancer metastasis, some of macrophages make pre-metastatic niche in which circulating tumor cells are induced to extravasate. They secret various cytokines, matrix metalloproteinase (MMPs) and soluble factors promoting extracellular matrix (ECM) degradation [1]. However, the explanation regarding how monocyte (macrophage precursor)/macrophage work in pre-metastatic niche has not been clearly unveiled. We developed a 3D in vitro microfluidic chip containing ECM scaffold. This system provides physiological microenvironment resembling in vivo.
AB - Cancer cell needs supportive microenvironments to survive in metastatic region. During cancer metastasis, some of macrophages make pre-metastatic niche in which circulating tumor cells are induced to extravasate. They secret various cytokines, matrix metalloproteinase (MMPs) and soluble factors promoting extracellular matrix (ECM) degradation [1]. However, the explanation regarding how monocyte (macrophage precursor)/macrophage work in pre-metastatic niche has not been clearly unveiled. We developed a 3D in vitro microfluidic chip containing ECM scaffold. This system provides physiological microenvironment resembling in vivo.
KW - 3D cancer invasion
KW - Microfluidic device
KW - Monocytes
KW - Pre-metastatic niche
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UR - http://www.scopus.com/inward/citedby.url?scp=85014262545&partnerID=8YFLogxK
M3 - Conference contribution
SP - 77
EP - 78
BT - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
PB - Chemical and Biological Microsystems Society
ER -