@inproceedings{a54999f96bb241b1b2c27afff289cbd2,
title = "3-Dimensional in vitro model for studying monocyte-induced pre-metastatic cancer invasion",
abstract = "Cancer cell needs supportive microenvironments to survive in metastatic region. During cancer metastasis, some of macrophages make pre-metastatic niche in which circulating tumor cells are induced to extravasate. They secret various cytokines, matrix metalloproteinase (MMPs) and soluble factors promoting extracellular matrix (ECM) degradation [1]. However, the explanation regarding how monocyte (macrophage precursor)/macrophage work in pre-metastatic niche has not been clearly unveiled. We developed a 3D in vitro microfluidic chip containing ECM scaffold. This system provides physiological microenvironment resembling in vivo.",
keywords = "3D cancer invasion, Microfluidic device, Monocytes, Pre-metastatic niche",
author = "Hyunho Kim and Hyewon Chung and Yoojin Shin and Choi, {Dong Hee} and Seok Chung and Seok, {Seung Hyeok}",
note = "Funding Information: This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI14C3418) This research was supported by the Pioneer Research Center Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT & Future Planning (NRF-2015M3C1A3002152).; 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 ; Conference date: 09-10-2016 Through 13-10-2016",
year = "2016",
language = "English",
series = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016",
publisher = "Chemical and Biological Microsystems Society",
pages = "77--78",
booktitle = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016",
}
