3-dimensional in vitro nasal mucosa modeling on a micro-fluidic chip

Kyu Hwan Na, Hyun Woo Shin, Seok Chung

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The objective of our research was to construct in vitro 3D nasal mucosa for further researches such as inducing nasal diseases and drugs screening. We simplified in vivo nasal mucosa into human primary nasal epithelial cell (hNEC), human microvascular endothelial cell (hMVEC) and extracellular matrix. Furthermore, we used an airway culture method because hNEC's conditions are better than previous liquid-covered culture method and more in vivo like[1]. We tried to find best conditions for co-culturing and to observe interaction between two cells. Finally, we constructed in vitro nasal mucosa model, and now we are going to use this model for drug screening.

Original languageEnglish
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages476-478
Number of pages3
ISBN (Print)9780979806476
Publication statusPublished - 2014
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: 2014 Oct 262014 Oct 30

Other

Other18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
CountryUnited States
CitySan Antonio
Period14/10/2614/10/30

Keywords

  • Airway culture
  • Co-culture
  • Microchip
  • Nasal mucosa

ASJC Scopus subject areas

  • Control and Systems Engineering

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  • Cite this

    Na, K. H., Shin, H. W., & Chung, S. (2014). 3-dimensional in vitro nasal mucosa modeling on a micro-fluidic chip. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (pp. 476-478). Chemical and Biological Microsystems Society.