Abstract
The objective of our research was to construct in vitro 3D nasal mucosa for further researches such as inducing nasal diseases and drugs screening. We simplified in vivo nasal mucosa into human primary nasal epithelial cell (hNEC), human microvascular endothelial cell (hMVEC) and extracellular matrix. Furthermore, we used an airway culture method because hNEC's conditions are better than previous liquid-covered culture method and more in vivo like[1]. We tried to find best conditions for co-culturing and to observe interaction between two cells. Finally, we constructed in vitro nasal mucosa model, and now we are going to use this model for drug screening.
| Original language | English |
|---|---|
| Title of host publication | 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 476-478 |
| Number of pages | 3 |
| ISBN (Print) | 9780979806476 |
| Publication status | Published - 2014 |
| Event | 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States Duration: 2014 Oct 26 → 2014 Oct 30 |
Other
| Other | 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 |
|---|---|
| Country | United States |
| City | San Antonio |
| Period | 14/10/26 → 14/10/30 |
Keywords
- Airway culture
- Co-culture
- Microchip
- Nasal mucosa
ASJC Scopus subject areas
- Control and Systems Engineering
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Cite this
Na, K. H., Shin, H. W., & Chung, S. (2014). 3-dimensional in vitro nasal mucosa modeling on a micro-fluidic chip. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (pp. 476-478). Chemical and Biological Microsystems Society.