3D in vitro high throughput screening model for analysis of colorectal cancer organoid by radiotherapy and chemotherapy for precision medicine

Dong Hee Choi, Yong Hun Jung, Seung Chul Shin, Ji Hun Yang, Seok Chung

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Organoids have been attracting much attention in precision medicine research because they are formed similar to structures and constructs of human tissues and possess most of the genetic data. However, there is a problem that the current method of organoid culture is not suitable for high throughput screening. In this study, a high throughput screening model using organoids was presented and several colorectal cancer were analyzed based on this. The responses of the organoids to radiotherapy and chemotherapy was analyzed using this model, and the results were consistent with the genetic data of the organoids.

Original languageEnglish
Title of host publication23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PublisherChemical and Biological Microsystems Society
Pages420-421
Number of pages2
ISBN (Electronic)9781733419000
Publication statusPublished - 2019
Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland
Duration: 2019 Oct 272019 Oct 31

Publication series

Name23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Conference

Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
CountrySwitzerland
CityBasel
Period19/10/2719/10/31

Keywords

  • Chemotherapy
  • High throughput screening
  • Organoid
  • Radiotherapy
  • Uniform

ASJC Scopus subject areas

  • Bioengineering
  • Chemical Engineering (miscellaneous)

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