3D in vitro high throughput screening model for analysis of colorectal cancer organoid by radiotherapy and chemotherapy for precision medicine

Dong Hee Choi; Yong Hun Jung; Seung Chul Shin; Ji Hun Yang; Seok Chung

3D in vitro high throughput screening model for analysis of colorectal cancer organoid by radiotherapy and chemotherapy for precision medicine

Dong Hee Choi, Yong Hun Jung, Seung Chul Shin, Ji Hun Yang, Seok Chung

School of Mechanical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Organoids have been attracting much attention in precision medicine research because they are formed similar to structures and constructs of human tissues and possess most of the genetic data. However, there is a problem that the current method of organoid culture is not suitable for high throughput screening. In this study, a high throughput screening model using organoids was presented and several colorectal cancer were analyzed based on this. The responses of the organoids to radiotherapy and chemotherapy was analyzed using this model, and the results were consistent with the genetic data of the organoids.

Original language	English
Title of host publication	23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
Publisher	Chemical and Biological Microsystems Society
Pages	420-421
Number of pages	2
ISBN (Electronic)	9781733419000
Publication status	Published - 2019
Event	23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland Duration: 2019 Oct 27 → 2019 Oct 31

Publication series

Name	23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Conference

Conference	23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
Country	Switzerland
City	Basel
Period	19/10/27 → 19/10/31

Keywords

Chemotherapy
High throughput screening
Organoid
Radiotherapy
Uniform

ASJC Scopus subject areas

Bioengineering
Chemical Engineering (miscellaneous)

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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Choi, D. H., Jung, Y. H., Shin, S. C., Yang, J. H., & Chung, S. (2019). 3D in vitro high throughput screening model for analysis of colorectal cancer organoid by radiotherapy and chemotherapy for precision medicine. In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 (pp. 420-421). (23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019). Chemical and Biological Microsystems Society.

3D in vitro high throughput screening model for analysis of colorectal cancer organoid by radiotherapy and chemotherapy for precision medicine. / Choi, Dong Hee; Jung, Yong Hun; Shin, Seung Chul; Yang, Ji Hun; Chung, Seok.

23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019. Chemical and Biological Microsystems Society, 2019. p. 420-421 (23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Choi, DH, Jung, YH, Shin, SC, Yang, JH & Chung, S 2019, 3D in vitro high throughput screening model for analysis of colorectal cancer organoid by radiotherapy and chemotherapy for precision medicine. in 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019. 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019, Chemical and Biological Microsystems Society, pp. 420-421, 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019, Basel, Switzerland, 19/10/27.

Choi DH, Jung YH, Shin SC, Yang JH, Chung S. 3D in vitro high throughput screening model for analysis of colorectal cancer organoid by radiotherapy and chemotherapy for precision medicine. In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019. Chemical and Biological Microsystems Society. 2019. p. 420-421. (23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019).

Choi, Dong Hee ; Jung, Yong Hun ; Shin, Seung Chul ; Yang, Ji Hun ; Chung, Seok. / 3D in vitro high throughput screening model for analysis of colorectal cancer organoid by radiotherapy and chemotherapy for precision medicine. 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019. Chemical and Biological Microsystems Society, 2019. pp. 420-421 (23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019).

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title = "3D in vitro high throughput screening model for analysis of colorectal cancer organoid by radiotherapy and chemotherapy for precision medicine",

abstract = "Organoids have been attracting much attention in precision medicine research because they are formed similar to structures and constructs of human tissues and possess most of the genetic data. However, there is a problem that the current method of organoid culture is not suitable for high throughput screening. In this study, a high throughput screening model using organoids was presented and several colorectal cancer were analyzed based on this. The responses of the organoids to radiotherapy and chemotherapy was analyzed using this model, and the results were consistent with the genetic data of the organoids.",

keywords = "Chemotherapy, High throughput screening, Organoid, Radiotherapy, Uniform",

author = "Choi, {Dong Hee} and Jung, {Yong Hun} and Shin, {Seung Chul} and Yang, {Ji Hun} and Seok Chung",

note = "Funding Information: This work was supported by the Technology Innovation Program (10067407, Development of high throughput organoid clearing system and 3D imaging system for drug) funded By the Ministry of Trade, industry & Energy(MOTIE, Korea) Publisher Copyright: {\textcopyright} 2019 CBMS-0001.; 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 ; Conference date: 27-10-2019 Through 31-10-2019",

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N1 - Funding Information: This work was supported by the Technology Innovation Program (10067407, Development of high throughput organoid clearing system and 3D imaging system for drug) funded By the Ministry of Trade, industry & Energy(MOTIE, Korea) Publisher Copyright: © 2019 CBMS-0001.

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N2 - Organoids have been attracting much attention in precision medicine research because they are formed similar to structures and constructs of human tissues and possess most of the genetic data. However, there is a problem that the current method of organoid culture is not suitable for high throughput screening. In this study, a high throughput screening model using organoids was presented and several colorectal cancer were analyzed based on this. The responses of the organoids to radiotherapy and chemotherapy was analyzed using this model, and the results were consistent with the genetic data of the organoids.

AB - Organoids have been attracting much attention in precision medicine research because they are formed similar to structures and constructs of human tissues and possess most of the genetic data. However, there is a problem that the current method of organoid culture is not suitable for high throughput screening. In this study, a high throughput screening model using organoids was presented and several colorectal cancer were analyzed based on this. The responses of the organoids to radiotherapy and chemotherapy was analyzed using this model, and the results were consistent with the genetic data of the organoids.

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3D in vitro high throughput screening model for analysis of colorectal cancer organoid by radiotherapy and chemotherapy for precision medicine

Abstract

Publication series

Conference

Keywords

ASJC Scopus subject areas

UN SDGs

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Cite this