Abstract
This study demonstrates the utility of camphene as the pore-regulating agent for phase separation-based 3D plotting to produce hierarchical macro/micro-porous poly(ε-caprolactone) (PCL)-calcium phosphate (CaP) composite scaffolds, specifically featuring highly microporous surfaces. Unlike conventional particulate porogens, camphene is highly soluble in acetone, the solvent for PCL polymer, but insoluble in coagulation medium (water). In this study, this unique characteristic supported the creation of numerous micropores both within and at the surfaces of PCL and PCL-CaP composite filaments when using high camphene contents (40 and 50 wt%). In addition, the incorporation of the CaP particles into PCL solutions did not deteriorate the formation of microporous structures, and thus hierarchical macro/micro-porous PCL-CaP composite scaffolds could be successfully produced. As the CaP content increased, the in vitro biocompatibility, apatite-forming ability, and mechanical properties (tensile strength, tensile modulus, and compressive modulus) of the PCL-CaP composite scaffolds were substantially improved.
| Original language | English |
|---|---|
| Article number | 2650 |
| Journal | Materials |
| Volume | 12 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2019 Jan 1 |
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Keywords
- 3D printing
- Hydroxyapatite
- In vitro bioactivity
- Poly(ε-caprolactone)
- Porous scaffolds
ASJC Scopus subject areas
- Materials Science(all)
Cite this
3D plotting using camphene as pore-regulating agent to produce hierarchical macro/micro-porous poly(ε-caprolactone)/calcium phosphate composite scaffolds. / Choi, Jae Won; Maeng, Woo Youl; Koh, Young-Hag; Lee, Hyun; Kim, Hyoun Ee.
In: Materials, Vol. 12, No. 7, 2650, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 3D plotting using camphene as pore-regulating agent to produce hierarchical macro/micro-porous poly(ε-caprolactone)/calcium phosphate composite scaffolds
AU - Choi, Jae Won
AU - Maeng, Woo Youl
AU - Koh, Young-Hag
AU - Lee, Hyun
AU - Kim, Hyoun Ee
PY - 2019/1/1
Y1 - 2019/1/1
N2 - This study demonstrates the utility of camphene as the pore-regulating agent for phase separation-based 3D plotting to produce hierarchical macro/micro-porous poly(ε-caprolactone) (PCL)-calcium phosphate (CaP) composite scaffolds, specifically featuring highly microporous surfaces. Unlike conventional particulate porogens, camphene is highly soluble in acetone, the solvent for PCL polymer, but insoluble in coagulation medium (water). In this study, this unique characteristic supported the creation of numerous micropores both within and at the surfaces of PCL and PCL-CaP composite filaments when using high camphene contents (40 and 50 wt%). In addition, the incorporation of the CaP particles into PCL solutions did not deteriorate the formation of microporous structures, and thus hierarchical macro/micro-porous PCL-CaP composite scaffolds could be successfully produced. As the CaP content increased, the in vitro biocompatibility, apatite-forming ability, and mechanical properties (tensile strength, tensile modulus, and compressive modulus) of the PCL-CaP composite scaffolds were substantially improved.
AB - This study demonstrates the utility of camphene as the pore-regulating agent for phase separation-based 3D plotting to produce hierarchical macro/micro-porous poly(ε-caprolactone) (PCL)-calcium phosphate (CaP) composite scaffolds, specifically featuring highly microporous surfaces. Unlike conventional particulate porogens, camphene is highly soluble in acetone, the solvent for PCL polymer, but insoluble in coagulation medium (water). In this study, this unique characteristic supported the creation of numerous micropores both within and at the surfaces of PCL and PCL-CaP composite filaments when using high camphene contents (40 and 50 wt%). In addition, the incorporation of the CaP particles into PCL solutions did not deteriorate the formation of microporous structures, and thus hierarchical macro/micro-porous PCL-CaP composite scaffolds could be successfully produced. As the CaP content increased, the in vitro biocompatibility, apatite-forming ability, and mechanical properties (tensile strength, tensile modulus, and compressive modulus) of the PCL-CaP composite scaffolds were substantially improved.
KW - 3D printing
KW - Hydroxyapatite
KW - In vitro bioactivity
KW - Poly(ε-caprolactone)
KW - Porous scaffolds
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UR - http://www.scopus.com/inward/citedby.url?scp=85071883018&partnerID=8YFLogxK
U2 - 10.3390/ma12172650
DO - 10.3390/ma12172650
M3 - Article
VL - 12
JO - Materials
JF - Materials
SN - 1996-1944
IS - 7
M1 - 2650
ER -