5-α Reductase inhibitory effect and astringent activity of green apple rind extract on human keratinocytes and fibroblast cells

Da Hee Son, Mi Hyun Nam, Chung Oui Hong, Hye Min Seol, Jae Eon Yang, Young Bu Kim, Cheong Tae Kim, Kwang Won Lee

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Unripe green apples contain condensed tannins at 10 times higher levels than ripe apples. Tannin not only has strong antioxidant activity, but also an astringent property. In this study, we investigated the effects of green apple rind (GAR) extracts in reducing facial pores and sebum secretion. Among the GAR extracts, the 70% ethanol GAR extract showed the highest antioxidant activity and tannin content. Hence, it was further fractionated with different solvents. Among these rind solvent fractions, the ethyl acetate fraction of the extract (GAR-E) showed astringent activity. Additionally, it exhibited inhibitory effects on 5-α reductase, and induced type 1 collagen and involucrin synthesis. These results suggest that GAR-E can be applied in cosmetics to reduce facial pore size and sebum secretion.

Original languageEnglish
Pages (from-to)714-721
Number of pages8
JournalBioscience, Biotechnology and Biochemistry
Volume77
Issue number4
DOIs
Publication statusPublished - 2013 Jun 14

Fingerprint

Astringents
Tannins
Malus
Fibroblasts
Keratinocytes
Oxidoreductases
Antioxidants
Cells
Proanthocyanidins
Cosmetics
Collagen Type I
Pore size
Sebum
Ethanol

Keywords

  • 5-α reductase
  • Antioxidant
  • Facial pores
  • Green apple
  • Sebum

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Analytical Chemistry
  • Organic Chemistry

Cite this

5-α Reductase inhibitory effect and astringent activity of green apple rind extract on human keratinocytes and fibroblast cells. / Son, Da Hee; Nam, Mi Hyun; Hong, Chung Oui; Seol, Hye Min; Yang, Jae Eon; Kim, Young Bu; Kim, Cheong Tae; Lee, Kwang Won.

In: Bioscience, Biotechnology and Biochemistry, Vol. 77, No. 4, 14.06.2013, p. 714-721.

Research output: Contribution to journalArticle

Son, Da Hee ; Nam, Mi Hyun ; Hong, Chung Oui ; Seol, Hye Min ; Yang, Jae Eon ; Kim, Young Bu ; Kim, Cheong Tae ; Lee, Kwang Won. / 5-α Reductase inhibitory effect and astringent activity of green apple rind extract on human keratinocytes and fibroblast cells. In: Bioscience, Biotechnology and Biochemistry. 2013 ; Vol. 77, No. 4. pp. 714-721.
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