A bioactive coating of a silica xerogel/chitosan hybrid on titanium by a room temperature sol-gel process

Shin H. Jun, Eun Jung Lee, Se W. Yook, Hyoun E. Kim, Hae W. Kim, Young-Hag Koh

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

A bioactive coating consisting of a silica xerogel/chitosan hybrid was applied to Ti at room temperature as a novel surface treatment for metallic implants. A crack-free thin layer (<2 μm) was coated on Ti with a chitosan content of >30 vol.% through a sol-gel process. The coating layer became more hydrophilic with increasing silica xerogel content, as assessed by contact angle measurement. The hybrid coatings afforded excellent bone bioactivity by inducing the rapid precipitation of apatite on their surface when immersed in a simulated body fluid (SBF). Osteoblastic cells cultured on the hybrid coatings were more viable than those on a pure chitosan coating. Furthermore, the alkaline phosphate activity of the cells was significantly higher on the hybrid coatings than on a pure chitosan coating, with the highest level being achieved on the hybrid coating containing 30% chitosan. These results indicate that silica xerogel/chitosan hybrids are potentially useful as room temperature bioactive coating materials on titanium-based medical implants.

Original languageEnglish
Pages (from-to)302-307
Number of pages6
JournalActa Biomaterialia
Volume6
Issue number1
DOIs
Publication statusPublished - 2010 Jan 1

Fingerprint

Xerogels
Chitosan
Polymethyl Methacrylate
Titanium
Silicon Dioxide
Sol-gel process
Gels
Silica
Coatings
Temperature
Apatites
Body Fluids
Cultured Cells
Body fluids
Phosphates
Apatite
Angle measurement
Bioactivity
Bone and Bones
Contact angle

Keywords

  • Bioactivity
  • Chitosan
  • Coating
  • Hybrid
  • Silica xerogel

ASJC Scopus subject areas

  • Biochemistry
  • Biotechnology
  • Molecular Biology
  • Biomedical Engineering
  • Biomaterials

Cite this

A bioactive coating of a silica xerogel/chitosan hybrid on titanium by a room temperature sol-gel process. / Jun, Shin H.; Lee, Eun Jung; Yook, Se W.; Kim, Hyoun E.; Kim, Hae W.; Koh, Young-Hag.

In: Acta Biomaterialia, Vol. 6, No. 1, 01.01.2010, p. 302-307.

Research output: Contribution to journalArticle

Jun, Shin H. ; Lee, Eun Jung ; Yook, Se W. ; Kim, Hyoun E. ; Kim, Hae W. ; Koh, Young-Hag. / A bioactive coating of a silica xerogel/chitosan hybrid on titanium by a room temperature sol-gel process. In: Acta Biomaterialia. 2010 ; Vol. 6, No. 1. pp. 302-307.
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