A bioactive coating of a silica xerogel/chitosan hybrid on titanium by a room temperature sol-gel process

Shin H. Jun, Eun Jung Lee, Se W. Yook, Hyoun E. Kim, Hae W. Kim, Young-Hag Koh

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A bioactive coating consisting of a silica xerogel/chitosan hybrid was applied to Ti at room temperature as a novel surface treatment for metallic implants. A crack-free thin layer (<2 μm) was coated on Ti with a chitosan content of >30 vol.% through a sol-gel process. The coating layer became more hydrophilic with increasing silica xerogel content, as assessed by contact angle measurement. The hybrid coatings afforded excellent bone bioactivity by inducing the rapid precipitation of apatite on their surface when immersed in a simulated body fluid (SBF). Osteoblastic cells cultured on the hybrid coatings were more viable than those on a pure chitosan coating. Furthermore, the alkaline phosphate activity of the cells was significantly higher on the hybrid coatings than on a pure chitosan coating, with the highest level being achieved on the hybrid coating containing 30% chitosan. These results indicate that silica xerogel/chitosan hybrids are potentially useful as room temperature bioactive coating materials on titanium-based medical implants.

Original languageEnglish
Pages (from-to)302-307
Number of pages6
JournalActa Biomaterialia
Issue number1
Publication statusPublished - 2010 Jan 1



  • Bioactivity
  • Chitosan
  • Coating
  • Hybrid
  • Silica xerogel

ASJC Scopus subject areas

  • Biochemistry
  • Biotechnology
  • Molecular Biology
  • Biomedical Engineering
  • Biomaterials

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