A bioorthogonal ‘turn-on’ fluorescent probe for tracking mitochondrial nitroxyl formation

Kyoung Sunwoo, Kondapa Naidu Bobba, Ja Yun Lim, Taegun Park, Arup Podder, June Seok Heo, Seung Gwan Lee, Sankarprasad Bhuniya, Jong Seung Kim

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

A bioreductant-resistant ‘turn-on’ chemodosimetric fluorescent probe Mito-1 has been developed for the detection of mitochondrial HNO in live cells. Mito-1 enables the detection of HNO as low as ∼18 nM. It has the capability to detect both exogenous and endogenous mitochondrial HNO formations in cellular milieus by providing fluorescence images. Its two-photon imaging ability fosters its use as a noninvasive imaging tool for the detection of mitochondrial nitroxyl.

Original languageEnglish
Pages (from-to)1723-1726
Number of pages4
JournalChemical Communications
Volume53
Issue number10
DOIs
Publication statusPublished - 2017

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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  • Cite this

    Sunwoo, K., Bobba, K. N., Lim, J. Y., Park, T., Podder, A., Heo, J. S., Lee, S. G., Bhuniya, S., & Kim, J. S. (2017). A bioorthogonal ‘turn-on’ fluorescent probe for tracking mitochondrial nitroxyl formation. Chemical Communications, 53(10), 1723-1726. https://doi.org/10.1039/c6cc09082f