A biotin-guided fluorescent-peptide drug delivery system for cancer treatment

Taeyoung Kim, Hyun Mi Jeon, Hoa Thi Le, Tae Woo Kim, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Herein, we present a fluorescent-peptide drug delivery system composed of biotin-naphthalimide-HJ inhibitor peptide2, prodrug 1. Treatment of 1 to biotin receptor-positive HepG2 cells, which are resistant to high concentrations of the HJ inhibitor peptide2, decreased cell viability and increased intracellular fluorescence.

Original languageEnglish
Pages (from-to)7690-7693
Number of pages4
JournalChemical Communications
Volume50
Issue number57
DOIs
Publication statusPublished - 2014 Jul 21

Fingerprint

Naphthalimides
Oncology
Prodrugs
Hep G2 Cells
Drug Delivery Systems
Biotin
Peptides
Cell Survival
Fluorescence
Cells
Neoplasms
Therapeutics
biotin receptor

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys

Cite this

A biotin-guided fluorescent-peptide drug delivery system for cancer treatment. / Kim, Taeyoung; Jeon, Hyun Mi; Le, Hoa Thi; Kim, Tae Woo; Kang, Chulhun; Kim, Jong Seung.

In: Chemical Communications, Vol. 50, No. 57, 21.07.2014, p. 7690-7693.

Research output: Contribution to journalArticle

Kim, Taeyoung ; Jeon, Hyun Mi ; Le, Hoa Thi ; Kim, Tae Woo ; Kang, Chulhun ; Kim, Jong Seung. / A biotin-guided fluorescent-peptide drug delivery system for cancer treatment. In: Chemical Communications. 2014 ; Vol. 50, No. 57. pp. 7690-7693.
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