A brønsted acid catalyst for the enantioselective protonation reaction

Cheol-Hong Cheon, Hisashi Yamamoto

Research output: Contribution to journalArticle

187 Citations (Scopus)

Abstract

A highly reactive and robust chiral Brønsted acid catalyst, chiral N-triflyl thiophosphoramide, was developed. The first metal-free Brønsted acid catalyzed enantioselective protonation reaction of silyl enol ethers was demonstrated using this chiral Brønsted acid catalyst. The catalyst loading could be reduced to 0.05 mol % without any deleterious effect on the enantioselectivity.

Original languageEnglish
Pages (from-to)9246-9247
Number of pages2
JournalJournal of the American Chemical Society
Volume130
Issue number29
DOIs
Publication statusPublished - 2008 Jul 23
Externally publishedYes

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Protonation
Catalysts
Acids
Ethers
Enantioselectivity
Metals

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

A brønsted acid catalyst for the enantioselective protonation reaction. / Cheon, Cheol-Hong; Yamamoto, Hisashi.

In: Journal of the American Chemical Society, Vol. 130, No. 29, 23.07.2008, p. 9246-9247.

Research output: Contribution to journalArticle

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