A candidate single nucleotide polymorphism in the 3' untranslated region of stearoyl-CoA desaturase gene for fatness quality and the gene expression in berkshire pigs

Kyu Sang Lim, Jun Mo Kim, Eun A. Lee, Jee Hwan Choe, Ki Chang Hong

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Fatness qualities in pigs measured by the amount of fat deposition and composition of fatty acids (FAs) in pork have considerable effect on current breeding goals. The stearoyl-CoA desaturase (SCD) gene plays a crucial role in the conversion of saturated FAs into monounsaturated FAs (MUFAs), and hence, is among the candidate genes responsible for pig fatness traits. Here, we identified a single nucleotide polymorphism (SNP, c.∗2041T>C) in the 3' untranslated region by direct sequencing focused on coding and regulatory regions of porcine SCD. According to the association analysis using a hundred of Berkshire pigs, the SNP was significantly associated with FA composition (MUFAs and polyunsaturated FAs [PUFAs]), polyunsaturated to saturated (P:S) FA ratio, n-6:n-3 FA ratio, and extent of fat deposition such as intramuscular fat and marbling (p<0.05). In addition, the SNP showed a significant effect on the SCD mRNA expression levels (p = 0.041). Based on our results, we suggest that the SCD c.∗2041T>C SNP plays a role in the gene regulation and affects the fatness qualities in Berkshire pigs.

Original languageEnglish
Pages (from-to)151-157
Number of pages7
JournalAsian-Australasian Journal of Animal Sciences
Volume28
Issue number2
DOIs
Publication statusPublished - 2015 Feb 1

Keywords

  • Berkshire
  • Fatness quality
  • Polymorphism gene expression
  • Stearoyl-CoA desaturase [SCD]

ASJC Scopus subject areas

  • Food Science
  • Animal Science and Zoology
  • Engineering(all)

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