A case of fixed drug eruption induced by tegafur-uracil(tegasil)

Young Soo Heo, Hae Jun Song, Chil Hwan Oh

Research output: Contribution to journalArticle

Abstract

A mixture of tegafur and uracil (TEGASIL) is a common antineoplastic agent. Tegafur is a fluoropyrimidine structurally similar to 5-fluorouracil (5-FU); uracil slows the degradation of 5-FU by dihydropyrimidine dehydrogenase, which results in higher 5-FU concentrations in tumors. Mucocutaneous side effects induced by this agent are rare and include photosensitivity of lichenoid and eczematous types, acral erythema, hyperpigmentation and palmoplantar keratoderma. However, there have been no reports of fixed drug eruption associated with TEGASIL. We report here on a case of fixed drug eruption due to oral TEGASIL. (Korean J Dermatol 2010;48(2):155-157).

Original languageEnglish
Pages (from-to)155-157
Number of pages3
JournalKorean Journal of Dermatology
Volume48
Issue number2
Publication statusPublished - 2010 Feb 1

Fingerprint

Tegafur
Drug Eruptions
Uracil
Fluorouracil
Palmoplantar Keratoderma
Dihydrouracil Dehydrogenase (NADP)
Hyperpigmentation
Erythema
Antineoplastic Agents
Extremities
Neoplasms

Keywords

  • Fixed drug eruption
  • Tegafur
  • Tegasil

ASJC Scopus subject areas

  • Dermatology

Cite this

A case of fixed drug eruption induced by tegafur-uracil(tegasil). / Heo, Young Soo; Song, Hae Jun; Oh, Chil Hwan.

In: Korean Journal of Dermatology, Vol. 48, No. 2, 01.02.2010, p. 155-157.

Research output: Contribution to journalArticle

Heo, Young Soo ; Song, Hae Jun ; Oh, Chil Hwan. / A case of fixed drug eruption induced by tegafur-uracil(tegasil). In: Korean Journal of Dermatology. 2010 ; Vol. 48, No. 2. pp. 155-157.
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