A case of granulomatous lung disease in a patient with Good's syndrome

Seung Heon Lee, Sang Min Lee, Seok Chul Yang, Chul Gyu Yoo, Young Whan Kim, Young Soo Shim, Sung Koo Han

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10 Citations (Scopus)


Good's syndrome is extremely rare. This adult-onset condition is characterized by a thymoma with immunodeficiency, low B- and T-cell counts, and hypo-gammaglobulinemia. The initial clinical presentation is either a mass-lesion thymoma or a recurrent infection. Patients with Good's syndrome are very susceptible to infections; common respiratory and opportunistic infections can be life-threatening. There are no reports of granulomatous lung disease in patients with Good's syndrome, although it has been observed in patients with common variable immunodeficiency, of which Good's syndrome is a subset. We describe a 53-year-old male thymoma patient who presented with respiratory symptoms caused by granulomatous lung disease and an opportunistic infection. He died of uncontrolled fungal infection despite repeated intravenous immunoglobulin and supportive care. Clinicians should look for evidence of immunologic dysfunction in thymoma patients presenting with severe recurrent infections, especially opportunistic infections.

Original languageEnglish
Pages (from-to)219-222
Number of pages4
JournalKorean Journal of Internal Medicine
Issue number4
Publication statusPublished - 2008
Externally publishedYes


  • Immunodeficiency
  • Opportunistic infection
  • Thymoma

ASJC Scopus subject areas

  • Internal Medicine


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