Abstract
Perivascular epithelioid cell tumors (PEComas) refers to a family of mesenchymal neoplasms composed of angiomyolipomas, clear cell "sugar" tumors of the lung, and lymphangioleiomyomatoses. These tumors have a distinctive and common component of perivascular epithelioid cells that show an association with blood vessel walls and immunohistochemically display myomelanocytic differentiation. The unique neoplasms have been shown to have an expanded range through a variety of case reports, including visceral, intra-abdominal, soft tissue, and bone tumors. The retroperitoneum, abdominopelvic region, and uterus have been reported to be the most common sites. Most PEComas follow a benign course. However, reports of malignant PEComas are increasing. Many papers have described uterine PEComas, but to our knowledge, there have not yet been any reports of a malignant PEComa arising concomitant with another epithelial tumor and mesenchymal tumor. We report herein the case of a 67-year-old woman who experienced a malignant uterine PEComa infiltrating a preexisting intramural leiomyoma with synchronous well differentiated endometrial carcinoma and multiple liver and lung metastases.
| Original language | English |
|---|---|
| Pages (from-to) | 469-473 |
| Number of pages | 5 |
| Journal | Journal of Pathology and Translational Medicine |
| Volume | 50 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2016 |
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Keywords
- Immunihistochemistry
- Perivascular epithelioid cell neoplasms
- Uterus
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology
Cite this
A case of malignant PEComa of the uterus associated with intramural leiomyoma and endometrial carcinoma. / Choi, Yoo Jin; Hong, Jin-Hwa; Kim, Aeree; Kim, Han Kyeom; Chang, Hyeyoon.
In: Journal of Pathology and Translational Medicine, Vol. 50, No. 6, 2016, p. 469-473.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A case of malignant PEComa of the uterus associated with intramural leiomyoma and endometrial carcinoma
AU - Choi, Yoo Jin
AU - Hong, Jin-Hwa
AU - Kim, Aeree
AU - Kim, Han Kyeom
AU - Chang, Hyeyoon
PY - 2016
Y1 - 2016
N2 - Perivascular epithelioid cell tumors (PEComas) refers to a family of mesenchymal neoplasms composed of angiomyolipomas, clear cell "sugar" tumors of the lung, and lymphangioleiomyomatoses. These tumors have a distinctive and common component of perivascular epithelioid cells that show an association with blood vessel walls and immunohistochemically display myomelanocytic differentiation. The unique neoplasms have been shown to have an expanded range through a variety of case reports, including visceral, intra-abdominal, soft tissue, and bone tumors. The retroperitoneum, abdominopelvic region, and uterus have been reported to be the most common sites. Most PEComas follow a benign course. However, reports of malignant PEComas are increasing. Many papers have described uterine PEComas, but to our knowledge, there have not yet been any reports of a malignant PEComa arising concomitant with another epithelial tumor and mesenchymal tumor. We report herein the case of a 67-year-old woman who experienced a malignant uterine PEComa infiltrating a preexisting intramural leiomyoma with synchronous well differentiated endometrial carcinoma and multiple liver and lung metastases.
AB - Perivascular epithelioid cell tumors (PEComas) refers to a family of mesenchymal neoplasms composed of angiomyolipomas, clear cell "sugar" tumors of the lung, and lymphangioleiomyomatoses. These tumors have a distinctive and common component of perivascular epithelioid cells that show an association with blood vessel walls and immunohistochemically display myomelanocytic differentiation. The unique neoplasms have been shown to have an expanded range through a variety of case reports, including visceral, intra-abdominal, soft tissue, and bone tumors. The retroperitoneum, abdominopelvic region, and uterus have been reported to be the most common sites. Most PEComas follow a benign course. However, reports of malignant PEComas are increasing. Many papers have described uterine PEComas, but to our knowledge, there have not yet been any reports of a malignant PEComa arising concomitant with another epithelial tumor and mesenchymal tumor. We report herein the case of a 67-year-old woman who experienced a malignant uterine PEComa infiltrating a preexisting intramural leiomyoma with synchronous well differentiated endometrial carcinoma and multiple liver and lung metastases.
KW - Immunihistochemistry
KW - Perivascular epithelioid cell neoplasms
KW - Uterus
UR - http://www.scopus.com/inward/record.url?scp=85006150325&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85006150325&partnerID=8YFLogxK
U2 - 10.4132/jptm.2016.04.20
DO - 10.4132/jptm.2016.04.20
M3 - Article
VL - 50
SP - 469
EP - 473
JO - Journal of Pathology and Translational Medicine
JF - Journal of Pathology and Translational Medicine
SN - 2383-7837
IS - 6
ER -