A case of melanoacanthoma

Immunohistochemical staining using vector® novaredtm to distinguish melanocytes from the cutaneous pigment

Jae Eun Choi, Eui Jong Bae, Aeree Kim, Sang Wook Son, Hae Jun Song, Chil Hwan Oh

Research output: Contribution to journalArticle

Abstract

Melanoacanthoma is a rare benign mixed tumor of both keratinocytes and melanocytes. Although some authors said that it is a rare variant of seborrheic keratosis, it has clinical and histological features distinct from seborrheic keratosis. It has large dendritic melanin-laden melanocytes throughout all levels of epidermis showing a disruption of melanin transfer from the melanocytes to neighboring keratinocytes. However, it is difficult to distinguish melanocytes clearly from cutaneous pigment in immunohistochemical stain with usually used brown chromogen. We used chromogen with brick-red indicator product (VECTOR® NovaRED™) in S-100 and melan-A immunohistochemical staining to distinguish melanocytes from melanin laden keratinocytes. We suggest that the immunohistochemical staining using this novel chromogen may be useful in the diagnosis of melanoacanthoma.

Original languageEnglish
Pages (from-to)18-21
Number of pages4
JournalAnnals of Dermatology
Volume20
Issue number1
Publication statusPublished - 2008 Jan 1

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Melanocytes
Staining and Labeling
Melanins
Skin
Keratinocytes
Seborrheic Keratosis
MART-1 Antigen
Epidermis
Coloring Agents
Neoplasms

ASJC Scopus subject areas

  • Dermatology

Cite this

A case of melanoacanthoma : Immunohistochemical staining using vector® novaredtm to distinguish melanocytes from the cutaneous pigment. / Choi, Jae Eun; Bae, Eui Jong; Kim, Aeree; Son, Sang Wook; Song, Hae Jun; Oh, Chil Hwan.

In: Annals of Dermatology, Vol. 20, No. 1, 01.01.2008, p. 18-21.

Research output: Contribution to journalArticle

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