A case of mottled hypopigmentation after low-fluence 1,064-nm Q-switched neodymium-doped yttrium aluminum garnet laser therapy

Hwa Jung Ryu, Jiehoon Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Melasma is a very difficult pigmented disease to treat with high recurrence rate. Using low-fluence 1,064-nm Q-switched neodymium-doped yttrium aluminum garnet (QSNY) lasers repeatedly for the treatment of melasma is now a common practice in East Asia. However, one of the significant side effects is mottled hypopigmentation that appears as scattered white macules in the middle of melasma lesion. The pathophysiology of these hypopigmentation is yet unknown. The biopsy of the hypopigmented lesion showed decreased melanosome with intact melanocytes, and topical tretinoin may be the effective solution for these types of condition.

Original languageEnglish
Pages (from-to)290-292
Number of pages3
JournalJournal of Cosmetic and Laser Therapy
Volume15
Issue number5
DOIs
Publication statusPublished - 2013 Oct 1

Fingerprint

Hypopigmentation
Melanosis
Solid-State Lasers
Laser Therapy
Melanosomes
Far East
Melanocytes
Tretinoin
Biopsy
Recurrence
Therapeutics

Keywords

  • Lasers and light sources
  • Topical agents

ASJC Scopus subject areas

  • Surgery
  • Dermatology

Cite this

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abstract = "Melasma is a very difficult pigmented disease to treat with high recurrence rate. Using low-fluence 1,064-nm Q-switched neodymium-doped yttrium aluminum garnet (QSNY) lasers repeatedly for the treatment of melasma is now a common practice in East Asia. However, one of the significant side effects is mottled hypopigmentation that appears as scattered white macules in the middle of melasma lesion. The pathophysiology of these hypopigmentation is yet unknown. The biopsy of the hypopigmented lesion showed decreased melanosome with intact melanocytes, and topical tretinoin may be the effective solution for these types of condition.",
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