A case of occupational rhinitis caused by porcine pancreatic extract developing into occupational asthma

Youp Shin Seung, Young Hur Gyu, Min Ye Young, Sim Park Hae

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    Porcine pancreatic extracts (PPE), which are widely used as a digestive drug in Korea, are composed of -amylase and lipase. Such enzymes are commonly described as occupational allergens. This is the first report of occupational rhinitis caused by PPE developing into occupational asthma in a hospital nurse. She showed strong positive response in the skin prick test (SPT) (5+, wheal ratio of allergen to histamine) and had a high serum-specific IgE level to PPE, but showed a negative response in the methacholine bronchial challenge test (MBT). She had been exposed to PPE intermittently with intermittent medications for rhinitis. Two years later, she presented with rhinitis and additional asthmatic symptoms. In contrast to her first visit, she showed a positive response in the MBT, and developed bronchoconstriction in the PPE-bronchial provocation test (BPT). These findings suggest that inhalation of PPE powder can induce IgE-mediated occupational rhinitis in a hospital setting, which will develop into occupational asthma if avoidance is not complete.

    Original languageEnglish
    Pages (from-to)347-349
    Number of pages3
    JournalJournal of Korean medical science
    Volume23
    Issue number2
    DOIs
    Publication statusPublished - 2008 Apr

    Keywords

    • Occupational asthma
    • Occupational rhinitis
    • Pancreatic extracts
    • Specific IgE

    ASJC Scopus subject areas

    • Medicine(all)

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