A case of paraneoplastic limbic encephalitis associated with small cell lung cancer

Ja Young Ryu, Seung Hyeun Lee, Eun Joo Lee, Kyung Hoon Min, Gyu Young Hur, Sung Yong Lee, Je Hyeong Kim, Sang Yeub Lee, Choi Shin, Jae Jeong Shim, Kwang Ho In, Kyung Ho Kang, Se Hwa Yoo

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Paraneoplastic limbic encephalitis (PLE) is a rare syndrome characterized by memory impairment, affective and behavioral disturbances and seizures. Among many different neoplasms known to cause PLE, small cell lung cancer (SCLC) is the most frequently reported. The pathogenesis is not fully understood but is believed to be autoimmune-related. We experienced a patient with typical clinical features of PLE. A 67-year-old man presented with seizure and disorientation. Brain magnetic resonance imaging demonstrated high signal intensity in the bilateral amygdala and hippocampus in flair and T2-weighted images suggestive of limbic encephalitis. Cerebrospinal fluid tapping revealed no evidence of malignant cells or infection. Positron emission tomography/computed tomography showed a lung mass with pleural effusion and a consequent biopsy confirmed the diagnosis of PLE associated with SCLC. The patient was subsequently treated with chemotherapy and neurologic symptoms gradually improved. Copyright

Original languageEnglish
Pages (from-to)273-277
Number of pages5
JournalTuberculosis and Respiratory Diseases
Volume73
Issue number5
DOIs
Publication statusPublished - 2012 Nov

Keywords

  • Limbic encephalitis
  • Lung neoplasms
  • Paraneoplastic syndromes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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