A case of paraneoplastic limbic encephalitis associated with small cell lung cancer

Ja Young Ryu; Seung Hyeun Lee; Eun Joo Lee; Kyung Hoon Min; Gyu Young Hur; Sung Yong Lee; Je Hyeong Kim; Sang Yeub Lee; Choi Shin; Jae Jeong Shim; Kwang Ho In; Kyung Ho Kang; Se Hwa Yoo

doi:10.4046/trd.2012.73.5.273

A case of paraneoplastic limbic encephalitis associated with small cell lung cancer

Ja Young Ryu, Seung Hyeun Lee, Eun Joo Lee, Kyung Hoon Min, Gyu Young Hur, Sung Yong Lee, Je Hyeong Kim, Sang Yeub Lee, Choi Shin, Jae Jeong Shim, Kwang Ho In, Kyung Ho Kang, Se Hwa Yoo

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Paraneoplastic limbic encephalitis (PLE) is a rare syndrome characterized by memory impairment, affective and behavioral disturbances and seizures. Among many different neoplasms known to cause PLE, small cell lung cancer (SCLC) is the most frequently reported. The pathogenesis is not fully understood but is believed to be autoimmune-related. We experienced a patient with typical clinical features of PLE. A 67-year-old man presented with seizure and disorientation. Brain magnetic resonance imaging demonstrated high signal intensity in the bilateral amygdala and hippocampus in flair and T2-weighted images suggestive of limbic encephalitis. Cerebrospinal fluid tapping revealed no evidence of malignant cells or infection. Positron emission tomography/computed tomography showed a lung mass with pleural effusion and a consequent biopsy confirmed the diagnosis of PLE associated with SCLC. The patient was subsequently treated with chemotherapy and neurologic symptoms gradually improved. Copyright

Original language	English
Pages (from-to)	273-277
Number of pages	5
Journal	Tuberculosis and Respiratory Diseases
Volume	73
Issue number	5
DOIs	https://doi.org/10.4046/trd.2012.73.5.273
Publication status	Published - 2012 Nov

Keywords

Limbic encephalitis
Lung neoplasms
Paraneoplastic syndromes

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4046/trd.2012.73.5.273

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title = "A case of paraneoplastic limbic encephalitis associated with small cell lung cancer",

abstract = "Paraneoplastic limbic encephalitis (PLE) is a rare syndrome characterized by memory impairment, affective and behavioral disturbances and seizures. Among many different neoplasms known to cause PLE, small cell lung cancer (SCLC) is the most frequently reported. The pathogenesis is not fully understood but is believed to be autoimmune-related. We experienced a patient with typical clinical features of PLE. A 67-year-old man presented with seizure and disorientation. Brain magnetic resonance imaging demonstrated high signal intensity in the bilateral amygdala and hippocampus in flair and T2-weighted images suggestive of limbic encephalitis. Cerebrospinal fluid tapping revealed no evidence of malignant cells or infection. Positron emission tomography/computed tomography showed a lung mass with pleural effusion and a consequent biopsy confirmed the diagnosis of PLE associated with SCLC. The patient was subsequently treated with chemotherapy and neurologic symptoms gradually improved. Copyright",

keywords = "Limbic encephalitis, Lung neoplasms, Paraneoplastic syndromes",

author = "Ryu, {Ja Young} and Lee, {Seung Hyeun} and Lee, {Eun Joo} and Min, {Kyung Hoon} and Hur, {Gyu Young} and Lee, {Sung Yong} and Kim, {Je Hyeong} and Lee, {Sang Yeub} and Choi Shin and Shim, {Jae Jeong} and In, {Kwang Ho} and Kang, {Kyung Ho} and Yoo, {Se Hwa}",

year = "2012",

month = nov,

doi = "10.4046/trd.2012.73.5.273",

language = "English",

volume = "73",

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AU - Ryu, Ja Young

AU - Lee, Seung Hyeun

AU - Lee, Eun Joo

AU - Min, Kyung Hoon

AU - Hur, Gyu Young

AU - Lee, Sung Yong

AU - Kim, Je Hyeong

AU - Lee, Sang Yeub

AU - Shin, Choi

AU - Shim, Jae Jeong

AU - In, Kwang Ho

AU - Kang, Kyung Ho

AU - Yoo, Se Hwa

PY - 2012/11

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N2 - Paraneoplastic limbic encephalitis (PLE) is a rare syndrome characterized by memory impairment, affective and behavioral disturbances and seizures. Among many different neoplasms known to cause PLE, small cell lung cancer (SCLC) is the most frequently reported. The pathogenesis is not fully understood but is believed to be autoimmune-related. We experienced a patient with typical clinical features of PLE. A 67-year-old man presented with seizure and disorientation. Brain magnetic resonance imaging demonstrated high signal intensity in the bilateral amygdala and hippocampus in flair and T2-weighted images suggestive of limbic encephalitis. Cerebrospinal fluid tapping revealed no evidence of malignant cells or infection. Positron emission tomography/computed tomography showed a lung mass with pleural effusion and a consequent biopsy confirmed the diagnosis of PLE associated with SCLC. The patient was subsequently treated with chemotherapy and neurologic symptoms gradually improved. Copyright

AB - Paraneoplastic limbic encephalitis (PLE) is a rare syndrome characterized by memory impairment, affective and behavioral disturbances and seizures. Among many different neoplasms known to cause PLE, small cell lung cancer (SCLC) is the most frequently reported. The pathogenesis is not fully understood but is believed to be autoimmune-related. We experienced a patient with typical clinical features of PLE. A 67-year-old man presented with seizure and disorientation. Brain magnetic resonance imaging demonstrated high signal intensity in the bilateral amygdala and hippocampus in flair and T2-weighted images suggestive of limbic encephalitis. Cerebrospinal fluid tapping revealed no evidence of malignant cells or infection. Positron emission tomography/computed tomography showed a lung mass with pleural effusion and a consequent biopsy confirmed the diagnosis of PLE associated with SCLC. The patient was subsequently treated with chemotherapy and neurologic symptoms gradually improved. Copyright

KW - Limbic encephalitis

KW - Lung neoplasms

KW - Paraneoplastic syndromes

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SN - 1738-3536

VL - 73

SP - 273

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JF - Tuberculosis and Respiratory Diseases

IS - 5

ER -

A case of paraneoplastic limbic encephalitis associated with small cell lung cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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