A case of pleural effusion due to vasculitis in scleroderma

Y. H. Lee, J. J. Sim, K. H. Kang, G. G. Song

Research output: Contribution to journalArticle


Systemic sclerosis is a multisystemic disease of unknown origin characterized by degenerative fibrotic and inflammatory changes in the skin, vessels, joints, muscles, and visceral organs. Involvement of the lung in systemic sclerosis is common, but pleural effusion is rare. Although vasculitis commonly accompanies many corrective tissue disorders, it has been rarely reported in systemic sclerosis. A 43-year-old woman, with a 10-year history of Raynaud's phenomenon, was admitted due to right chest pain. Her hands showed diffuse thickening and swelling of skin. Chest X-ray showed pleural effusions and esophageal manometry showed hypotonic peristalsis and low lower esophageal sphincter tone compatible with scleroderma esophagus. Antinuclear antibodies were present (titer > 1:160) with a speckled pattern. She was positive for rheumatoid factor, anti scl-70 and RNP antibodies, but negative for anti-Ro, La, and Sm antibodies. Histology of the pleura revealed the presence of leukocytoclastic vasculitis. After administration of prednisolone 30 mg/day, her chest symptom was improved. We report a case of systemic sclerosis with pleural effusions due to leukocytoclastic vasculitis with review of the literatures.

Original languageEnglish
Pages (from-to)786-791
Number of pages6
JournalTuberculosis and Respiratory Diseases
Issue number5
Publication statusPublished - 1996 Jan 1


  • pleural effusion
  • systemic sclerosis
  • vasculitis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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