A case of primary pulmonary NK/T cell lymphoma presenting as pneumonia

Sangho Lee; Bongkyung Shin; Hyungseok Yoon; Jung Yeon Lee; Gyu Rak Chon

doi:10.1016/j.rmcr.2015.11.003

A case of primary pulmonary NK/T cell lymphoma presenting as pneumonia

Sangho Lee, Bongkyung Shin, Hyungseok Yoon, Jung Yeon Lee, Gyu Rak Chon

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Primary pulmonary lymphoma, particularly non-B cell lymphomas involving lung parenchyma, is very rare. A 46-year-old male was admitted to the hospital with fever and cough. Chest X-ray showed left lower lobe consolidation, which was considered pneumonia. However, because the patient showed no response to empirical antibiotic therapy, bronchoscopic biopsy was performed for proper diagnosis. The biopsied specimen showed infiltrated atypical lymphocytes with angiocentric appearance. On immunohistochemical staining, these atypical cells were positive for CD3, CD30, CD56, MUM-1, and granzyme B, and labeled for Epstein-Barr virus encoded RNA in situ hybridization. These findings were consistent with NK/T cell lymphoma. We report on a case of primary pulmonary NK/T cell lymphoma presenting as pneumonic symptoms and review the literature on the subject.

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	Respiratory Medicine Case Reports
Volume	17
DOIs	https://doi.org/10.1016/j.rmcr.2015.11.003
Publication status	Published - 2016 Jan 1
Externally published	Yes

Keywords

Epstein-Barr virus
Lymphoma
NK-T cell lymphoma
Pneumonia

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

Access to Document

10.1016/j.rmcr.2015.11.003

Cite this

@article{aa98e94440a84e2a8ad810f43f644f5c,

title = "A case of primary pulmonary NK/T cell lymphoma presenting as pneumonia",

abstract = "Primary pulmonary lymphoma, particularly non-B cell lymphomas involving lung parenchyma, is very rare. A 46-year-old male was admitted to the hospital with fever and cough. Chest X-ray showed left lower lobe consolidation, which was considered pneumonia. However, because the patient showed no response to empirical antibiotic therapy, bronchoscopic biopsy was performed for proper diagnosis. The biopsied specimen showed infiltrated atypical lymphocytes with angiocentric appearance. On immunohistochemical staining, these atypical cells were positive for CD3, CD30, CD56, MUM-1, and granzyme B, and labeled for Epstein-Barr virus encoded RNA in situ hybridization. These findings were consistent with NK/T cell lymphoma. We report on a case of primary pulmonary NK/T cell lymphoma presenting as pneumonic symptoms and review the literature on the subject.",

keywords = "Epstein-Barr virus, Lymphoma, NK-T cell lymphoma, Pneumonia",

author = "Sangho Lee and Bongkyung Shin and Hyungseok Yoon and Lee, {Jung Yeon} and Chon, {Gyu Rak}",

note = "Publisher Copyright: {\textcopyright} 2015 The Authors.",

year = "2016",

month = jan,

day = "1",

doi = "10.1016/j.rmcr.2015.11.003",

language = "English",

volume = "17",

pages = "1--4",

journal = "Respiratory Medicine Case Reports",

issn = "2213-0071",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - A case of primary pulmonary NK/T cell lymphoma presenting as pneumonia

AU - Lee, Sangho

AU - Shin, Bongkyung

AU - Yoon, Hyungseok

AU - Lee, Jung Yeon

AU - Chon, Gyu Rak

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Primary pulmonary lymphoma, particularly non-B cell lymphomas involving lung parenchyma, is very rare. A 46-year-old male was admitted to the hospital with fever and cough. Chest X-ray showed left lower lobe consolidation, which was considered pneumonia. However, because the patient showed no response to empirical antibiotic therapy, bronchoscopic biopsy was performed for proper diagnosis. The biopsied specimen showed infiltrated atypical lymphocytes with angiocentric appearance. On immunohistochemical staining, these atypical cells were positive for CD3, CD30, CD56, MUM-1, and granzyme B, and labeled for Epstein-Barr virus encoded RNA in situ hybridization. These findings were consistent with NK/T cell lymphoma. We report on a case of primary pulmonary NK/T cell lymphoma presenting as pneumonic symptoms and review the literature on the subject.

AB - Primary pulmonary lymphoma, particularly non-B cell lymphomas involving lung parenchyma, is very rare. A 46-year-old male was admitted to the hospital with fever and cough. Chest X-ray showed left lower lobe consolidation, which was considered pneumonia. However, because the patient showed no response to empirical antibiotic therapy, bronchoscopic biopsy was performed for proper diagnosis. The biopsied specimen showed infiltrated atypical lymphocytes with angiocentric appearance. On immunohistochemical staining, these atypical cells were positive for CD3, CD30, CD56, MUM-1, and granzyme B, and labeled for Epstein-Barr virus encoded RNA in situ hybridization. These findings were consistent with NK/T cell lymphoma. We report on a case of primary pulmonary NK/T cell lymphoma presenting as pneumonic symptoms and review the literature on the subject.

KW - Epstein-Barr virus

KW - Lymphoma

KW - NK-T cell lymphoma

KW - Pneumonia

UR - http://www.scopus.com/inward/record.url?scp=84949216767&partnerID=8YFLogxK

U2 - 10.1016/j.rmcr.2015.11.003

DO - 10.1016/j.rmcr.2015.11.003

M3 - Article

AN - SCOPUS:84949216767

SN - 2213-0071

VL - 17

SP - 1

EP - 4

JO - Respiratory Medicine Case Reports

JF - Respiratory Medicine Case Reports

ER -

A case of primary pulmonary NK/T cell lymphoma presenting as pneumonia

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this