A case of propylthiouracil induced diffuse pulmonary hemorrhage

Sung Yong Lee, Jin Yong Jung, Kyoung Ju Lee, Seung Hyeun Lee, Se Joong Kim, Eun Joo Lee, Gyu Young Hur, Hae Chul Jung, Sang Yeub Lee, Je Hyeong Kim, Chol Shin, Jae Jeong Shim, Kwang Ho In, Kyung Ho Kang, Se Hwa Yoo

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Abstract

Propylthiouracil(PUT) is a drug which used at Grave's disease. But PTU has recently been observed to associated with antineutrophil cytoplasmic antibody(ANCA)-positive vasculitis resulting in, infrequently, diffuse alveolar hemorrhage. We report the case of a patient who developed diffuse pulmonary hemorrhage after she had been taking PTU for two years. She had received a diagnosis of Grave's disease at two years ago. The serologic study was positive for ANCA with myeloperoxidase(MPO) specificity. Bronchoalveloar lavage(BAL) fluid analysis revealed hemosiderinladen macrophages. Such findings suggested propylthiouracil induced dffuse pulmonary hemorrhage associated with antineutrophil cytoplasmic antibody. To our knowledge, this represents the first documentation in a case of PTU-induced diffuse pulmonary hemorrhage in Korea.

Original languageEnglish
Pages (from-to)78-82
Number of pages5
JournalTuberculosis and Respiratory Diseases
Volume58
Issue number1
Publication statusPublished - 2005 Jan 1

Keywords

  • ANCA
  • Diffuse alveolar hemorrhage
  • Propylthiouracil

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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