A case of pulmonary lymphomatoid granulomatosis successfully treated by combination chemotherapy with rituximab

Ki Hwan Jung, Hwa Jung Sung, Ju Han Lee, Ki Yeol Lee, Jae Seung Shin, Kyung Min Kim, Young Sik Kim, Chol Shin, Je Hyeong Kim

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Lymphomatoid granulomatosis (LYG) is a rare angiocentric and angiodestructive lymphoproliferative disease characterized by Epstein-Barr virus-positive B cells admixed with reactive T cells. LYG most commonly affects the lung but can also involve other extrapulmonary sites. Pulmonary LYG usually presents as multiple pulmonary nodules with rapid progression and excavation. It can mimic various infectious diseases, vasculitis or metastatic malignancy and is difficult to be diagnosed clinically. Standard treatment for LYG has not yet been established. Despite combination chemotherapy, the overall prognosis is poor. Recently, anti-CD20 monoclonal antibody, rituximab, has been used to treat LYG. We report the case of a 70-year-old male patient with pulmonary LYG, who showed rapid remission of the disease after combination chemotherapy with rituximab.

Original languageEnglish
Pages (from-to)386-390
Number of pages5
JournalChemotherapy
Volume55
Issue number5
DOIs
Publication statusPublished - 2009

Keywords

  • Combination chemotherapy
  • Lymphomatoid granulomatosis
  • Monoclonal antibodies

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Drug Discovery
  • Pharmacology (medical)
  • Infectious Diseases

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