A case of subcutaneous phaeohyphomycosis caused by Exophiala oligosperma showing multiple cysts

Tae Hyung Ryu, In Hyuk Kwon, Jae Eun Choi, Hyo Hyun Ahn, Young Chul Kye, Soo-Hong Seo

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Exophiala species are dark pigmented fungi associated with phaeohyphomycosis that exhibit yeast-like or hyphal forms of the fungus in superficial subcutaneous locations or systemic disease. The incidence of subcutaneous tissue infection of Exophiala species has recently increased, particularly in immunocompromised hosts. In Korea, E. jeanselmei, E. dermatitidis, and E. salmonis were isolated from patients with phaeohyphomycosis. However, there have been no case reports of phaeohyphomycosis caused by E. oligosperma. Here we report the first case of phaeohyphomycosis caused by E. oligosperma in Korea. An 82-year-old female with competent immune function presented with multiple subcutaneous masses on the dorsum of the left hand and wrist. A histopathological examination of the skin specimen revealed granulomatous inflammation with fungal hyphae and yeast. Molecular identification was performed using internal transcribed spacer sequences analysis. The sequence showed 100% identity with the E. oligosperma strains. She was treated with oral itraconazole and showed improvement.

Original languageEnglish
Pages (from-to)259-263
Number of pages5
JournalKorean Journal of Dermatology
Volume55
Issue number4
Publication statusPublished - 2017 May 1

Fingerprint

Phaeohyphomycosis
Exophiala
Cysts
Korea
Fungi
Yeasts
Itraconazole
Hyphae
Subcutaneous Tissue
Immunocompromised Host
Wrist
Sequence Analysis
Hand
Inflammation
Skin
Incidence
Infection

Keywords

  • Exophiala oligosperma
  • Immunocompetent
  • Phaeohyphomycosis
  • Phaeohyphomycotic cyst

ASJC Scopus subject areas

  • Dermatology

Cite this

A case of subcutaneous phaeohyphomycosis caused by Exophiala oligosperma showing multiple cysts. / Ryu, Tae Hyung; Kwon, In Hyuk; Choi, Jae Eun; Ahn, Hyo Hyun; Kye, Young Chul; Seo, Soo-Hong.

In: Korean Journal of Dermatology, Vol. 55, No. 4, 01.05.2017, p. 259-263.

Research output: Contribution to journalArticle

@article{cf6c12c4e1184287be78854307ad907c,
title = "A case of subcutaneous phaeohyphomycosis caused by Exophiala oligosperma showing multiple cysts",
abstract = "Exophiala species are dark pigmented fungi associated with phaeohyphomycosis that exhibit yeast-like or hyphal forms of the fungus in superficial subcutaneous locations or systemic disease. The incidence of subcutaneous tissue infection of Exophiala species has recently increased, particularly in immunocompromised hosts. In Korea, E. jeanselmei, E. dermatitidis, and E. salmonis were isolated from patients with phaeohyphomycosis. However, there have been no case reports of phaeohyphomycosis caused by E. oligosperma. Here we report the first case of phaeohyphomycosis caused by E. oligosperma in Korea. An 82-year-old female with competent immune function presented with multiple subcutaneous masses on the dorsum of the left hand and wrist. A histopathological examination of the skin specimen revealed granulomatous inflammation with fungal hyphae and yeast. Molecular identification was performed using internal transcribed spacer sequences analysis. The sequence showed 100{\%} identity with the E. oligosperma strains. She was treated with oral itraconazole and showed improvement.",
keywords = "Exophiala oligosperma, Immunocompetent, Phaeohyphomycosis, Phaeohyphomycotic cyst",
author = "Ryu, {Tae Hyung} and Kwon, {In Hyuk} and Choi, {Jae Eun} and Ahn, {Hyo Hyun} and Kye, {Young Chul} and Soo-Hong Seo",
year = "2017",
month = "5",
day = "1",
language = "English",
volume = "55",
pages = "259--263",
journal = "Korean Journal of Dermatology",
issn = "0494-4739",
publisher = "Korean Dermatological Association",
number = "4",

}

TY - JOUR

T1 - A case of subcutaneous phaeohyphomycosis caused by Exophiala oligosperma showing multiple cysts

AU - Ryu, Tae Hyung

AU - Kwon, In Hyuk

AU - Choi, Jae Eun

AU - Ahn, Hyo Hyun

AU - Kye, Young Chul

AU - Seo, Soo-Hong

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Exophiala species are dark pigmented fungi associated with phaeohyphomycosis that exhibit yeast-like or hyphal forms of the fungus in superficial subcutaneous locations or systemic disease. The incidence of subcutaneous tissue infection of Exophiala species has recently increased, particularly in immunocompromised hosts. In Korea, E. jeanselmei, E. dermatitidis, and E. salmonis were isolated from patients with phaeohyphomycosis. However, there have been no case reports of phaeohyphomycosis caused by E. oligosperma. Here we report the first case of phaeohyphomycosis caused by E. oligosperma in Korea. An 82-year-old female with competent immune function presented with multiple subcutaneous masses on the dorsum of the left hand and wrist. A histopathological examination of the skin specimen revealed granulomatous inflammation with fungal hyphae and yeast. Molecular identification was performed using internal transcribed spacer sequences analysis. The sequence showed 100% identity with the E. oligosperma strains. She was treated with oral itraconazole and showed improvement.

AB - Exophiala species are dark pigmented fungi associated with phaeohyphomycosis that exhibit yeast-like or hyphal forms of the fungus in superficial subcutaneous locations or systemic disease. The incidence of subcutaneous tissue infection of Exophiala species has recently increased, particularly in immunocompromised hosts. In Korea, E. jeanselmei, E. dermatitidis, and E. salmonis were isolated from patients with phaeohyphomycosis. However, there have been no case reports of phaeohyphomycosis caused by E. oligosperma. Here we report the first case of phaeohyphomycosis caused by E. oligosperma in Korea. An 82-year-old female with competent immune function presented with multiple subcutaneous masses on the dorsum of the left hand and wrist. A histopathological examination of the skin specimen revealed granulomatous inflammation with fungal hyphae and yeast. Molecular identification was performed using internal transcribed spacer sequences analysis. The sequence showed 100% identity with the E. oligosperma strains. She was treated with oral itraconazole and showed improvement.

KW - Exophiala oligosperma

KW - Immunocompetent

KW - Phaeohyphomycosis

KW - Phaeohyphomycotic cyst

UR - http://www.scopus.com/inward/record.url?scp=85021817700&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021817700&partnerID=8YFLogxK

M3 - Article

VL - 55

SP - 259

EP - 263

JO - Korean Journal of Dermatology

JF - Korean Journal of Dermatology

SN - 0494-4739

IS - 4

ER -