A case of syndrome of inappropriate secretion of antidiuretic hormone following chemotherapy in a patient with non-small-cell lung cancer

Kyoung Ju Lee, Jae Young Moon, Sung Yong Lee, Sang Yeub Lee, Je Hyeong Kim, Chol Shin, Jae Jeong Shim, Kwang Ho In, Kyung Ho Kang, Se Hwa Yoo

Research output: Contribution to journalArticle

Abstract

The syndrome of inappropriate secretion of the antidiuretic hormone (SIADH) is a well recognized paraneoplastic phenomenon related to impaired water excretion, and can result in dilutional hyponatremia as well as central nervous system symptoms. It is characterized by a decrease in plasma osmolarity with inappropriately concentrated urine. The causes of SIADH are associated with pulmonary and endocrine disorders, central nervous system diseases, and malignancies, including lung cancer. The other causes of SIADH include some drugs, particularly chemotherapy agents. Anticancer drugs, such as cisplatin, vincristine, and cyclophosphamide are well known causes of SIADH but the mechanisms are unclear. Recently, we encountered a patient with advanced non-small cell lung cancer who suffered from general weakness and altered mentality after an intravenous carboplatin and gemcitabine combination.

Original languageEnglish
Pages (from-to)324-328
Number of pages5
JournalTuberculosis and Respiratory Diseases
Volume66
Issue number4
DOIs
Publication statusPublished - 2009 Apr 1

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Inappropriate ADH Syndrome
Vasopressins
Non-Small Cell Lung Carcinoma
gemcitabine
Drug Therapy
Hyponatremia
Carboplatin
Central Nervous System Diseases
Vincristine
Pharmaceutical Preparations
Osmolar Concentration
Cyclophosphamide
Cisplatin
Lung Neoplasms
Central Nervous System
Urine
Lung
Water
Neoplasms

Keywords

  • Carboplatin
  • Hyponatremia
  • Inappropriate ADH syndrome
  • Non-small-cell lung carcinoma

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

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title = "A case of syndrome of inappropriate secretion of antidiuretic hormone following chemotherapy in a patient with non-small-cell lung cancer",
abstract = "The syndrome of inappropriate secretion of the antidiuretic hormone (SIADH) is a well recognized paraneoplastic phenomenon related to impaired water excretion, and can result in dilutional hyponatremia as well as central nervous system symptoms. It is characterized by a decrease in plasma osmolarity with inappropriately concentrated urine. The causes of SIADH are associated with pulmonary and endocrine disorders, central nervous system diseases, and malignancies, including lung cancer. The other causes of SIADH include some drugs, particularly chemotherapy agents. Anticancer drugs, such as cisplatin, vincristine, and cyclophosphamide are well known causes of SIADH but the mechanisms are unclear. Recently, we encountered a patient with advanced non-small cell lung cancer who suffered from general weakness and altered mentality after an intravenous carboplatin and gemcitabine combination.",
keywords = "Carboplatin, Hyponatremia, Inappropriate ADH syndrome, Non-small-cell lung carcinoma",
author = "Lee, {Kyoung Ju} and Moon, {Jae Young} and Lee, {Sung Yong} and Lee, {Sang Yeub} and Kim, {Je Hyeong} and Chol Shin and Shim, {Jae Jeong} and In, {Kwang Ho} and Kang, {Kyung Ho} and Yoo, {Se Hwa}",
year = "2009",
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T1 - A case of syndrome of inappropriate secretion of antidiuretic hormone following chemotherapy in a patient with non-small-cell lung cancer

AU - Lee, Kyoung Ju

AU - Moon, Jae Young

AU - Lee, Sung Yong

AU - Lee, Sang Yeub

AU - Kim, Je Hyeong

AU - Shin, Chol

AU - Shim, Jae Jeong

AU - In, Kwang Ho

AU - Kang, Kyung Ho

AU - Yoo, Se Hwa

PY - 2009/4/1

Y1 - 2009/4/1

N2 - The syndrome of inappropriate secretion of the antidiuretic hormone (SIADH) is a well recognized paraneoplastic phenomenon related to impaired water excretion, and can result in dilutional hyponatremia as well as central nervous system symptoms. It is characterized by a decrease in plasma osmolarity with inappropriately concentrated urine. The causes of SIADH are associated with pulmonary and endocrine disorders, central nervous system diseases, and malignancies, including lung cancer. The other causes of SIADH include some drugs, particularly chemotherapy agents. Anticancer drugs, such as cisplatin, vincristine, and cyclophosphamide are well known causes of SIADH but the mechanisms are unclear. Recently, we encountered a patient with advanced non-small cell lung cancer who suffered from general weakness and altered mentality after an intravenous carboplatin and gemcitabine combination.

AB - The syndrome of inappropriate secretion of the antidiuretic hormone (SIADH) is a well recognized paraneoplastic phenomenon related to impaired water excretion, and can result in dilutional hyponatremia as well as central nervous system symptoms. It is characterized by a decrease in plasma osmolarity with inappropriately concentrated urine. The causes of SIADH are associated with pulmonary and endocrine disorders, central nervous system diseases, and malignancies, including lung cancer. The other causes of SIADH include some drugs, particularly chemotherapy agents. Anticancer drugs, such as cisplatin, vincristine, and cyclophosphamide are well known causes of SIADH but the mechanisms are unclear. Recently, we encountered a patient with advanced non-small cell lung cancer who suffered from general weakness and altered mentality after an intravenous carboplatin and gemcitabine combination.

KW - Carboplatin

KW - Hyponatremia

KW - Inappropriate ADH syndrome

KW - Non-small-cell lung carcinoma

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