A Case of Tenofovir-associated Fanconi Syndrome in Patient with Chronic Hepatitis B

Dongwoo Kim, Jongjin Lee, Dae Ha Kim, Kyuho Kang, Sang Jun Suh, Young Kul Jung, Hyung Joon Yim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Tenofovir disoproxil fumarate (TDF) is one of the most widely used treatment options for human immunodeficiency virus (HIV) and HBV infections. Despite its efficacy and safety, some cases of nephrotoxicity have been reported in the treatment of HIV patients. Even more recently, very few cases of Fanconi syndrome associated with tenofovir therapy in HBV monoinfection have been reported. Herein, we report a case of a 47-year-old male with an HBV monoinfection, who developed Fanconi syndrome and a secondary osteomalacia with multiple bone pain. After TDF withdrawal and supplementation of calcitriol, his renal function was reverted. Although the overall risk of TDF-associated nephrotoxicity is very low, both glomerular and tubular function should be monitored in patients undergoing TDF treatment.

Original languageEnglish
Pages (from-to)317-320
Number of pages4
JournalThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Volume68
Issue number6
DOIs
Publication statusPublished - 2016 Dec 25

Keywords

  • Fanconi syndrome
  • Hepatitis B virus
  • Kidney tubules, proximal
  • Osteomalacia
  • Tenofovir

ASJC Scopus subject areas

  • Medicine(all)

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