A case report of primary pericardial malignant mesothelioma treated with pemetrexed and cisplatin

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Abstract

Primary pericardial malignant mesothelioma (PPM) is a very rare malignancy, with an incidence of less than 0.002% and represents less than 5% of all mesotheliomas. The cause of pericardial mesothelioma is uncertain that differ from pleural mesothelioma which is associated with asbestos exposure. This malignancy is terribly aggressive and has very poor prognosis with less than six months of overall survival. We present a case of a 71-year-old woman who was diagnosed with cardiac tamponade caused by PPM and received chemotherapy with pemetrexed and cisplatin for six months. During two years she was alive without disease progression. To better understand the clinical, pathologic features and treatment outcome of this entity, we reviewed 23 cases described in the English literature from 2009, together with our case, provided a total of 24 cases. Based on this review, we suggest that PPM must be considered in patients who have unexplained massive pericardial effusion and recommend chemotherapy with pemetrexed and cisplatin for the better outcome of PPM.

Original languageEnglish
Pages (from-to)1879-1884
Number of pages6
JournalJournal of Korean Medical Science
Volume32
Issue number11
DOIs
Publication statusPublished - 2017 Nov 1

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Keywords

  • Cardiac tamponade
  • Cisplatin
  • Pemetrexed
  • Primary pericardial mesothelioma

ASJC Scopus subject areas

  • Medicine(all)

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