A case report of primary pericardial malignant mesothelioma treated with pemetrexed and cisplatin

Jung Sun Kim, Sang Yup Lim, Jinwook Hwang, Eun Joo Kang, Yoon Ji Choi

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    Primary pericardial malignant mesothelioma (PPM) is a very rare malignancy, with an incidence of less than 0.002% and represents less than 5% of all mesotheliomas. The cause of pericardial mesothelioma is uncertain that differ from pleural mesothelioma which is associated with asbestos exposure. This malignancy is terribly aggressive and has very poor prognosis with less than six months of overall survival. We present a case of a 71-year-old woman who was diagnosed with cardiac tamponade caused by PPM and received chemotherapy with pemetrexed and cisplatin for six months. During two years she was alive without disease progression. To better understand the clinical, pathologic features and treatment outcome of this entity, we reviewed 23 cases described in the English literature from 2009, together with our case, provided a total of 24 cases. Based on this review, we suggest that PPM must be considered in patients who have unexplained massive pericardial effusion and recommend chemotherapy with pemetrexed and cisplatin for the better outcome of PPM.

    Original languageEnglish
    Pages (from-to)1879-1884
    Number of pages6
    JournalJournal of Korean medical science
    Volume32
    Issue number11
    DOIs
    Publication statusPublished - 2017 Nov 1

    Keywords

    • Cardiac tamponade
    • Cisplatin
    • Pemetrexed
    • Primary pericardial mesothelioma

    ASJC Scopus subject areas

    • Medicine(all)

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