A chemodosimeter-modified carbon nanotube-field effect transistor: Toward a highly selective and sensitive electrical sensing platform

Chang Seuk Lee, Jong Seung Kim, Tae Hyun Kim

Research output: Contribution to journalArticle

Abstract

We present a carbon nanotube-field effect transistor (CNT-FET) biosensor which first implements the chemodosimeter sensing principle in CNT nanoelectronics. We experimentally illustrate the specific molecular interplay that the cysteine-selective chemodosimeter immobilized on the CNT surface can specifically interact with cysteine, which leads to the chemical transformation of the chemodosimeter. Since the chemical transformation of the chemodosimeter can disrupt the charge distribution in the vicinity of the CNT surface, the carrier equilibrium in CNT might be altered, and manifested by the conductivity change of CNT-FET. The real-Time conductance measurements show our biosensor is capable of label-free, rapid, highly selective and ultrasensitive detection of cysteine with a detection limit down to 0.45 fM. These results first verify the signaling principle competency of chemical transformation of the chemodosimeter in CNT electronic sensors. Combined with the advantages of the highly selective chemodosimeter and sensitive CNT-FET, the excellent performance of our sensor indicates its promising prospect as a valuable tool for developing highly sensitive and selective sensing platforms in practical application.

Original languageEnglish
Pages (from-to)28414-28420
Number of pages7
JournalRSC Advances
Volume9
Issue number49
DOIs
Publication statusPublished - 2019 Jan 1

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Carbon nanotube field effect transistors
Cysteine
Biosensors
Nanoelectronics
Charge distribution
Sensors
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ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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A chemodosimeter-modified carbon nanotube-field effect transistor : Toward a highly selective and sensitive electrical sensing platform. / Lee, Chang Seuk; Kim, Jong Seung; Kim, Tae Hyun.

In: RSC Advances, Vol. 9, No. 49, 01.01.2019, p. 28414-28420.

Research output: Contribution to journalArticle

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