A clinical case of scrub typhus in the united states forces korea patient with eschar and genetic identification of orientia tsutsugamushi using multiplex pcr-based next-generation sequencing

Seungchan Cho, Jon C. Allison, Kkothanahreum Park, Jin Sun No, Seung Ho Lee, Kyungmin Park, Jongwoo Kim, Terry A. Klein, Heung Chul Kim, Won Keun Kim, Jin Won Song

Research output: Contribution to journalArticlepeer-review

Abstract

An epidemiological investigation was conducted for a scrub typhus case reported in a U.S. Forces Korea military patient in the Republic of Korea in November 2018. The patient had a fever, maculopapular rash, and an eschar. The full-length sequence of Orientia tsutsugamushi 56-kDa type-specific antigen (TSA) gene was obtained from eschar tissue by multiplex PCR-based Next Generation Sequencing for genetic identification. Based on the 56-kDa TSA gene, the O. tsutsugamushi aligned most closely with the Boryong strain.

Original languageEnglish
Article number424
JournalPathogens
Volume10
Issue number4
DOIs
Publication statusPublished - 2021 Apr

Keywords

  • Genetic identification
  • Orientia tsutsugamushi
  • Scrub typhus
  • Target enrichment nextgeneration sequencing

ASJC Scopus subject areas

  • Immunology and Allergy
  • Molecular Biology
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

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