A compact optical system using LED and CMOS image sensor for liver function analysis

Chul Kim, Chang Jin Lim, Myung Hyun Nam, Dong Sik Kim, Sungkyu Seo, Jungho Pak

Research output: Contribution to journalArticle

Abstract

This paper presents a portable and compact optical device which can conveniently be used to perform a functional analysis of human liver function. The proposed system employed red/green LEDs, as a light source, and CMOS image sensor, which is commonly used in cellular phones. With this system, several blood serum samples have been evaluated for liver functional analysis by measuring light absorption level through the blood serum samples depending on aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin concentration. The light absorption through the blood serum samples containing AST, ALT, or total bilirubin can provide their concentrations. The green light absorption is more sensitive to the concentration of AST or ALT, and the red light absorption is more sensitive to the total bilirubuin concentration. Additional calibration steps were performed by using a MATLAB program in order to eliminate the light scattering effects from the extraneous particles existing in each blood serum sample. From the blind test, three standard light intensity curves through each enzyme have been obtained and the enzyme concentration values have been compared to those obtained from a commercially available biochemistry analyzer (Toshiba 200 FR). The average percent difference in the obtained concentrations from two systems for AST, ALT, and total bilirubin concentration came out to be 7.79%, 7.98%. and 7.56%, respectively, with the adjusted coefficient of determination (R 2) higher than 0.98. This system can possibly lead to a low-cost and simple system that can be used as a point-of-care (POC) system in a condition without advanced equipments.

Original languageEnglish
Pages (from-to)270-275
Number of pages6
JournalTransactions of the Korean Institute of Electrical Engineers
Volume61
Issue number2
Publication statusPublished - 2012 Feb 1

Fingerprint

Image sensors
Optical systems
Liver
Light absorption
Light emitting diodes
Blood
Functional analysis
Enzymes
Biochemistry
Optical devices
Light scattering
MATLAB
Light sources
Calibration
Costs

Keywords

  • Alt (alanine aminotransferase)
  • AST(Aspartate aminotransferase)
  • Cmos image sensor
  • LED
  • Liver function test
  • Low cost
  • Total bilirubin

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

Cite this

A compact optical system using LED and CMOS image sensor for liver function analysis. / Kim, Chul; Lim, Chang Jin; Nam, Myung Hyun; Kim, Dong Sik; Seo, Sungkyu; Pak, Jungho.

In: Transactions of the Korean Institute of Electrical Engineers, Vol. 61, No. 2, 01.02.2012, p. 270-275.

Research output: Contribution to journalArticle

@article{6cccce4ecb044a4f9e78397006e29834,
title = "A compact optical system using LED and CMOS image sensor for liver function analysis",
abstract = "This paper presents a portable and compact optical device which can conveniently be used to perform a functional analysis of human liver function. The proposed system employed red/green LEDs, as a light source, and CMOS image sensor, which is commonly used in cellular phones. With this system, several blood serum samples have been evaluated for liver functional analysis by measuring light absorption level through the blood serum samples depending on aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin concentration. The light absorption through the blood serum samples containing AST, ALT, or total bilirubin can provide their concentrations. The green light absorption is more sensitive to the concentration of AST or ALT, and the red light absorption is more sensitive to the total bilirubuin concentration. Additional calibration steps were performed by using a MATLAB program in order to eliminate the light scattering effects from the extraneous particles existing in each blood serum sample. From the blind test, three standard light intensity curves through each enzyme have been obtained and the enzyme concentration values have been compared to those obtained from a commercially available biochemistry analyzer (Toshiba 200 FR). The average percent difference in the obtained concentrations from two systems for AST, ALT, and total bilirubin concentration came out to be 7.79{\%}, 7.98{\%}. and 7.56{\%}, respectively, with the adjusted coefficient of determination (R 2) higher than 0.98. This system can possibly lead to a low-cost and simple system that can be used as a point-of-care (POC) system in a condition without advanced equipments.",
keywords = "Alt (alanine aminotransferase), AST(Aspartate aminotransferase), Cmos image sensor, LED, Liver function test, Low cost, Total bilirubin",
author = "Chul Kim and Lim, {Chang Jin} and Nam, {Myung Hyun} and Kim, {Dong Sik} and Sungkyu Seo and Jungho Pak",
year = "2012",
month = "2",
day = "1",
language = "English",
volume = "61",
pages = "270--275",
journal = "Transactions of the Korean Institute of Electrical Engineers",
issn = "1975-8359",
publisher = "Korean Institute of Electrical Engineers",
number = "2",

}

TY - JOUR

T1 - A compact optical system using LED and CMOS image sensor for liver function analysis

AU - Kim, Chul

AU - Lim, Chang Jin

AU - Nam, Myung Hyun

AU - Kim, Dong Sik

AU - Seo, Sungkyu

AU - Pak, Jungho

PY - 2012/2/1

Y1 - 2012/2/1

N2 - This paper presents a portable and compact optical device which can conveniently be used to perform a functional analysis of human liver function. The proposed system employed red/green LEDs, as a light source, and CMOS image sensor, which is commonly used in cellular phones. With this system, several blood serum samples have been evaluated for liver functional analysis by measuring light absorption level through the blood serum samples depending on aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin concentration. The light absorption through the blood serum samples containing AST, ALT, or total bilirubin can provide their concentrations. The green light absorption is more sensitive to the concentration of AST or ALT, and the red light absorption is more sensitive to the total bilirubuin concentration. Additional calibration steps were performed by using a MATLAB program in order to eliminate the light scattering effects from the extraneous particles existing in each blood serum sample. From the blind test, three standard light intensity curves through each enzyme have been obtained and the enzyme concentration values have been compared to those obtained from a commercially available biochemistry analyzer (Toshiba 200 FR). The average percent difference in the obtained concentrations from two systems for AST, ALT, and total bilirubin concentration came out to be 7.79%, 7.98%. and 7.56%, respectively, with the adjusted coefficient of determination (R 2) higher than 0.98. This system can possibly lead to a low-cost and simple system that can be used as a point-of-care (POC) system in a condition without advanced equipments.

AB - This paper presents a portable and compact optical device which can conveniently be used to perform a functional analysis of human liver function. The proposed system employed red/green LEDs, as a light source, and CMOS image sensor, which is commonly used in cellular phones. With this system, several blood serum samples have been evaluated for liver functional analysis by measuring light absorption level through the blood serum samples depending on aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin concentration. The light absorption through the blood serum samples containing AST, ALT, or total bilirubin can provide their concentrations. The green light absorption is more sensitive to the concentration of AST or ALT, and the red light absorption is more sensitive to the total bilirubuin concentration. Additional calibration steps were performed by using a MATLAB program in order to eliminate the light scattering effects from the extraneous particles existing in each blood serum sample. From the blind test, three standard light intensity curves through each enzyme have been obtained and the enzyme concentration values have been compared to those obtained from a commercially available biochemistry analyzer (Toshiba 200 FR). The average percent difference in the obtained concentrations from two systems for AST, ALT, and total bilirubin concentration came out to be 7.79%, 7.98%. and 7.56%, respectively, with the adjusted coefficient of determination (R 2) higher than 0.98. This system can possibly lead to a low-cost and simple system that can be used as a point-of-care (POC) system in a condition without advanced equipments.

KW - Alt (alanine aminotransferase)

KW - AST(Aspartate aminotransferase)

KW - Cmos image sensor

KW - LED

KW - Liver function test

KW - Low cost

KW - Total bilirubin

UR - http://www.scopus.com/inward/record.url?scp=84863238017&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863238017&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84863238017

VL - 61

SP - 270

EP - 275

JO - Transactions of the Korean Institute of Electrical Engineers

JF - Transactions of the Korean Institute of Electrical Engineers

SN - 1975-8359

IS - 2

ER -