A comparative pilot study of symptom improvement before and after phototherapy in Korean patients with perennial allergic rhinitis

Heung Man Lee, Man Sik Park, Il Ho Park, Seung Hoon Lee, Seong Keon Lee, Kyu Sung Kim, Hyuk Choi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Although allergic rhinitis is not life threatening, it significantly influences the quality of a patient's life. This study is intended to evaluate the safety and efficacy of phototherapy with low-level energy of a 650 nm laser irradiation system in perennial allergic rhinitis patients. This clinical trial was an open-label, single-center study with 42 perennial allergic rhinitis subjects. Following laser irradiation in the nasal cavity with a laser irradiation system, the efficacy at weeks 1 through 4 was determined. The symptoms were scored with four parameters (nasal obstruction, rhinorrhea, sneezing and itching) before and after illumination of the laser, and the total score was recorded. A survey of Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) was conducted by patients before and after treatment. Following treatment, significant improvement in the clinical symptoms of nasal obstruction (P < 0.001), rhinorrhea (P = 0.005), sneezing (P = 0.001) and itching (P = 0.003) was reported by 68% of perennial allergic rhinitis patients. The overall RQLQ scores significantly improved by 45% from the baseline with the treatment after 4 weeks. These results indicate that phototherapy is an effective modality for treating perennial allergic rhinitis and is another option in the steroid-free management of immune-mediated mucosal diseases.

Original languageEnglish
Pages (from-to)751-757
Number of pages7
JournalPhotochemistry and Photobiology
Volume89
Issue number3
DOIs
Publication statusPublished - 2013

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry

Fingerprint Dive into the research topics of 'A comparative pilot study of symptom improvement before and after phototherapy in Korean patients with perennial allergic rhinitis'. Together they form a unique fingerprint.

  • Cite this