A comparison study of cerebral autoregulation assessed with transcranial Doppler and cortical laser Doppler flowmetry

Christian Zweifel, Marek Czosnyka, Andrea Lavinio, Gianluca Castellani, Dong Ju Kim, Emmanuel Carrera, John D. Pickard, Peter J. Kirkpatrick, Peter Smielewski

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objectives: We compared autoregulation monitored with cortical laser Doppler flowmetry (LDF) and autoregulation monitored with transcranial Doppler (TCD) in the middle cerebral artery (MCA) to verify the hypothesis that, following brain trauma, cortical vessel autoregulation to intracranial hypertension is different than assessed in the MCA. Methods: Data collected from 29 head injured patients were analysed retrospectively. Arterial blood pressure (ABP), intracranial pressure (ICP), flow velocity (FV) of the MCA and cortical flux (LDF) were monitored. Indices of cortical autoregulation (Lx) and autoregulation of cerebral blood flow in the MCA (Mx) were calculated as a moving correlation coefficient between slow waves of LDF and cerebral perfusion pressure (CPP) (Lx) or FV and CPP (Mx), respectively. Intact autoregulation was indicated by negative values for Lx and Mx; disturbed autoregulation was reflected by positive values. Results: FV and LDF showed a high coherence in the slow wave spectrum of 1-4 cycles/min (mean: 0·79 ± 0·12), indicating that similar information regarding autoregulation is carried by both signals. Mx and Lx correlated in all patients (R=0·43, p=0·02). On average, Lx was significantly higher than Mx; the mean difference was 0·13 ± 0·38 (p=0·032), potentially due to severe intracranial hypertension above 40 mmHg, driving CPP values below 60 mmHg. Conclusion: After traumatic brain injury, cortical autoregulation appears to be worse than autoregulation assessed in the MCA during rising ICP and falling CPP. When CPP is above 60 mmHg, cortical assessed autoregulation is similar to autoregulation assessed in the MCA.

Original languageEnglish
Pages (from-to)425-428
Number of pages4
JournalNeurological Research
Volume32
Issue number4
DOIs
Publication statusPublished - 2010 May 1
Externally publishedYes

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Laser-Doppler Flowmetry
Cerebrovascular Circulation
Homeostasis
Middle Cerebral Artery
Intracranial Hypertension
Intracranial Pressure
Accidental Falls
Arterial Pressure
Head

Keywords

  • Autoregulation
  • Laser doppler flowmetry
  • Transcranial doppler

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

A comparison study of cerebral autoregulation assessed with transcranial Doppler and cortical laser Doppler flowmetry. / Zweifel, Christian; Czosnyka, Marek; Lavinio, Andrea; Castellani, Gianluca; Kim, Dong Ju; Carrera, Emmanuel; Pickard, John D.; Kirkpatrick, Peter J.; Smielewski, Peter.

In: Neurological Research, Vol. 32, No. 4, 01.05.2010, p. 425-428.

Research output: Contribution to journalArticle

Zweifel, C, Czosnyka, M, Lavinio, A, Castellani, G, Kim, DJ, Carrera, E, Pickard, JD, Kirkpatrick, PJ & Smielewski, P 2010, 'A comparison study of cerebral autoregulation assessed with transcranial Doppler and cortical laser Doppler flowmetry', Neurological Research, vol. 32, no. 4, pp. 425-428. https://doi.org/10.1179/174313209X459165
Zweifel, Christian ; Czosnyka, Marek ; Lavinio, Andrea ; Castellani, Gianluca ; Kim, Dong Ju ; Carrera, Emmanuel ; Pickard, John D. ; Kirkpatrick, Peter J. ; Smielewski, Peter. / A comparison study of cerebral autoregulation assessed with transcranial Doppler and cortical laser Doppler flowmetry. In: Neurological Research. 2010 ; Vol. 32, No. 4. pp. 425-428.
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AU - Lavinio, Andrea

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AU - Kim, Dong Ju

AU - Carrera, Emmanuel

AU - Pickard, John D.

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AB - Objectives: We compared autoregulation monitored with cortical laser Doppler flowmetry (LDF) and autoregulation monitored with transcranial Doppler (TCD) in the middle cerebral artery (MCA) to verify the hypothesis that, following brain trauma, cortical vessel autoregulation to intracranial hypertension is different than assessed in the MCA. Methods: Data collected from 29 head injured patients were analysed retrospectively. Arterial blood pressure (ABP), intracranial pressure (ICP), flow velocity (FV) of the MCA and cortical flux (LDF) were monitored. Indices of cortical autoregulation (Lx) and autoregulation of cerebral blood flow in the MCA (Mx) were calculated as a moving correlation coefficient between slow waves of LDF and cerebral perfusion pressure (CPP) (Lx) or FV and CPP (Mx), respectively. Intact autoregulation was indicated by negative values for Lx and Mx; disturbed autoregulation was reflected by positive values. Results: FV and LDF showed a high coherence in the slow wave spectrum of 1-4 cycles/min (mean: 0·79 ± 0·12), indicating that similar information regarding autoregulation is carried by both signals. Mx and Lx correlated in all patients (R=0·43, p=0·02). On average, Lx was significantly higher than Mx; the mean difference was 0·13 ± 0·38 (p=0·032), potentially due to severe intracranial hypertension above 40 mmHg, driving CPP values below 60 mmHg. Conclusion: After traumatic brain injury, cortical autoregulation appears to be worse than autoregulation assessed in the MCA during rising ICP and falling CPP. When CPP is above 60 mmHg, cortical assessed autoregulation is similar to autoregulation assessed in the MCA.

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