A comprehensive karyotypic analysis on a newly established sarcomatoid hepatocellular carcinoma cell line SH-J1 by comparative genomic hybridization and chromosome painting

Dae Ghon Kim, Soo Yeun Park, Hyun Kim, Yong Hyuck Chun, Woo Sung Moon, Sun-Hwa Park

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25 Citations (Scopus)

Abstract

We first established a sarcomatoid hepatocellular carcinoma cell line, designated as SH-J1, and applied comparative genomic hybridization and fluorescence in situ hybridization (FISH) with chromosome painting probes for the characterization of the chromosomal rearrangements. In the SH-J1 cell line, the pleomorphic spindle cells were arranged in bundles of interlacing patterns and were positive in immunohistochemical staining with hepatocyte-related markers. By G-banding and FISH, the chromosomal gains were detected at 6p and 17, whereas losses were observed at 3p21∼pter, 3q27∼qter, 4, 6q, 13pter∼q11, 16, 18, 19p13, and Y.

Original languageEnglish
Pages (from-to)120-124
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume132
Issue number2
DOIs
Publication statusPublished - 2002 Jan 15

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ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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