TY - JOUR
T1 - A computational method for longitudinal mapping of orientation-specific expansion of cortical surface in infants
AU - Xia, Jing
AU - Wang, Fan
AU - Meng, Yu
AU - Wu, Zhengwang
AU - Wang, Li
AU - Lin, Weili
AU - Zhang, Caiming
AU - Shen, Dinggang
AU - Li, Gang
N1 - Funding Information:
This work was partially supported by NIH grants (MH100217, MH108914, MH107815, MH109773, MH110274, MH116225, MH113255), National Natural Science Foundation of China (61373078, 61572292, 61332015, 61602277), National Natural Science Foundation of China Joint Fund with Zhejiang Integration of Informatization and Industrialization under Key Project (U1609218), and Nature Science Foundation of Shandong Province of China (ZR2016FQ12).
Funding Information:
This work was partially supported by NIH grants ( MH100217, MH108914, MH107815, MH109773, MH110274, MH116225, MH113255 ), National Natural Science Foundation of China ( 61373078, 61572292, 61332015, 61602277 ), National Natural Science Foundation of China Joint Fund with Zhejiang Integration of Informatization and Industrialization under Key Project ( U1609218 ), and Nature Science Foundation of Shandong Province of China ( ZR2016FQ12 ).
Publisher Copyright:
© 2018
PY - 2018/10
Y1 - 2018/10
N2 - The cortical surface of the human brain expands dynamically and regionally heterogeneously during the first postnatal year. As all primary and secondary cortical folds as well as many tertiary cortical folds are well established at term birth, the cortical surface area expansion during this stage is largely driven by the increase of surface area in two orthogonal orientations in the tangent plane: 1) the expansion parallel to the folding orientation (i.e., increasing the lengths of folds) and 2) the expansion perpendicular to the folding orientation (i.e., increasing the depths of folds). This information would help us better understand the mechanisms of cortical development and provide important insights into neurodevelopmental disorders, but still remains largely unknown due to lack of dedicated computational methods. To address this issue, we propose a novel method for longitudinal mapping of orientation-specific expansion of cortical surface area in these two orthogonal orientations during early infancy. First, to derive the two orientation fields perpendicular and parallel to cortical folds, we propose to adaptively and smoothly fuse the gradient field of sulcal depth and also the maximum principal direction field, by leveraging their region-specific reliability. Specifically, we formulate this task as a discrete labeling problem, in which each vertex is assigned to an orientation label, and solve it by graph cuts. Then, based on the computed longitudinal deformation of the cortical surface, we estimate the Jacobian matrix at each vertex by solving a least-squares problem and derive its corresponding stretch tensor. Finally, to obtain the orientation-specific cortical surface expansion, we project the stretch tensor into the two orthogonal orientations separately. We have applied the proposed method to 30 healthy infants, and for the first time we revealed the orientation-specific longitudinal cortical surface expansion maps during the first postnatal year.
AB - The cortical surface of the human brain expands dynamically and regionally heterogeneously during the first postnatal year. As all primary and secondary cortical folds as well as many tertiary cortical folds are well established at term birth, the cortical surface area expansion during this stage is largely driven by the increase of surface area in two orthogonal orientations in the tangent plane: 1) the expansion parallel to the folding orientation (i.e., increasing the lengths of folds) and 2) the expansion perpendicular to the folding orientation (i.e., increasing the depths of folds). This information would help us better understand the mechanisms of cortical development and provide important insights into neurodevelopmental disorders, but still remains largely unknown due to lack of dedicated computational methods. To address this issue, we propose a novel method for longitudinal mapping of orientation-specific expansion of cortical surface area in these two orthogonal orientations during early infancy. First, to derive the two orientation fields perpendicular and parallel to cortical folds, we propose to adaptively and smoothly fuse the gradient field of sulcal depth and also the maximum principal direction field, by leveraging their region-specific reliability. Specifically, we formulate this task as a discrete labeling problem, in which each vertex is assigned to an orientation label, and solve it by graph cuts. Then, based on the computed longitudinal deformation of the cortical surface, we estimate the Jacobian matrix at each vertex by solving a least-squares problem and derive its corresponding stretch tensor. Finally, to obtain the orientation-specific cortical surface expansion, we project the stretch tensor into the two orthogonal orientations separately. We have applied the proposed method to 30 healthy infants, and for the first time we revealed the orientation-specific longitudinal cortical surface expansion maps during the first postnatal year.
KW - Cortical folding
KW - Cortical surface expansion
KW - Infant brain development
KW - Longitudinal development
UR - http://www.scopus.com/inward/record.url?scp=85050986985&partnerID=8YFLogxK
U2 - 10.1016/j.media.2018.07.006
DO - 10.1016/j.media.2018.07.006
M3 - Article
C2 - 30092545
AN - SCOPUS:85050986985
SN - 1361-8415
VL - 49
SP - 46
EP - 59
JO - Medical Image Analysis
JF - Medical Image Analysis
ER -
