A coumarin-based fluorescence sensor for the reversible detection of thiols

A. Young Cho; Kihang Choi

doi:10.1246/cl.2012.1611

A coumarin-based fluorescence sensor for the reversible detection of thiols

A. Young Cho, Kihang Choi

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

A coumarin derivative with a cyanoacrylamide electrophile was prepared and used for fluorescence sensing of thiols. Thiol addition to the electrophile proceeded in a reversible manner so that the compound displayed fluorescence emission depending on thiol concentrations. Dissociation constants of the thiol addition products are in the mM ranges, which are similar to cellular thiol concentrations.

Original language	English
Pages (from-to)	1611-1612
Number of pages	2
Journal	Chemistry Letters
Volume	41
Issue number	12
DOIs	https://doi.org/10.1246/cl.2012.1611
Publication status	Published - 2012

ASJC Scopus subject areas

Chemistry(all)

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10.1246/cl.2012.1611

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abstract = "A coumarin derivative with a cyanoacrylamide electrophile was prepared and used for fluorescence sensing of thiols. Thiol addition to the electrophile proceeded in a reversible manner so that the compound displayed fluorescence emission depending on thiol concentrations. Dissociation constants of the thiol addition products are in the mM ranges, which are similar to cellular thiol concentrations.",

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AB - A coumarin derivative with a cyanoacrylamide electrophile was prepared and used for fluorescence sensing of thiols. Thiol addition to the electrophile proceeded in a reversible manner so that the compound displayed fluorescence emission depending on thiol concentrations. Dissociation constants of the thiol addition products are in the mM ranges, which are similar to cellular thiol concentrations.

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A coumarin-based fluorescence sensor for the reversible detection of thiols

Abstract

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