A coumarin-naphthalimide hybrid as a dual emissive fluorescent probe for hNQO1

Sun Young Park, Miae Won, Chulhun Kang, Jong Seung Kim, Min Hee Lee

Research output: Contribution to journalArticle

Abstract

hNQO1 is a promising target for cancer diagnosis and treatment. Here, we developed a coumarin-naphthalimide hybrid (1) as a dual emissive fluorescent probe that enhances the emission through hNQO1-mediated cleavage of its trimethyl lockquinone moiety. Probe 1 can be used for a real-time monitoring of hNQO1 activity in living cells.

Original languageEnglish
Pages (from-to)341-345
Number of pages5
JournalDyes and Pigments
Volume164
DOIs
Publication statusPublished - 2019 May 1

Fingerprint

Naphthalimides
Fluorescent Dyes
Cells
Monitoring
coumarin

Keywords

  • Coumarin
  • Dual emission imaging
  • hNQO1 detection
  • Naphthalimide

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Process Chemistry and Technology

Cite this

A coumarin-naphthalimide hybrid as a dual emissive fluorescent probe for hNQO1. / Park, Sun Young; Won, Miae; Kang, Chulhun; Kim, Jong Seung; Lee, Min Hee.

In: Dyes and Pigments, Vol. 164, 01.05.2019, p. 341-345.

Research output: Contribution to journalArticle

Park, Sun Young ; Won, Miae ; Kang, Chulhun ; Kim, Jong Seung ; Lee, Min Hee. / A coumarin-naphthalimide hybrid as a dual emissive fluorescent probe for hNQO1. In: Dyes and Pigments. 2019 ; Vol. 164. pp. 341-345.
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