A Cytotoxic Secocycloartenoid from Abies koreana

Hyun Jung Kim, Quoc Khanh Le, Mi Hyun Lee, Tae Sung Kim, Hyeong Kyu Lee, Young Ho Kim, Ki Hwan Bae, Ik Soo Lee

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Two triterpenoids, 24-methylene-3,4-seco-cycloart-4(28)-en-3-oic acid (1) and 3-oxo-9β- lanosta-7,22Z,24-trien-26,23-olide (6) were isolated from Abies koreana, together with β- sitosterol (2), maltol (3), β-sitosterol-O-β-D-glucoside (4), and hexacosylferulate (5). The structures of the compounds were established based on the spectroscopic data. The cytotoxic activities of triterpenoids have been evaluated using the sulforhodamine B (SRB) method. Compound 1 showed moderate cytotoxicities against human lung carcinoma (A549), ovarian carcinoma (SK-OV-3), malignant melanoma (SK-MEL-2), and colon carcinoma (HCT-15) cell lines.

Original languageEnglish
Pages (from-to)527-531
Number of pages5
JournalArchives of pharmacal research
Volume24
Issue number6
DOIs
Publication statusPublished - 2001

Keywords

  • 24-methylene-3,4-seco-cycloart-4(28)-en-3-oic acid
  • 3- Oxo-9β-lanosta-7,22z,24-trien-26,23-olide
  • Abies koreana
  • Cytotoxicity
  • Pinaceae

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    Kim, H. J., Le, Q. K., Lee, M. H., Kim, T. S., Lee, H. K., Kim, Y. H., Bae, K. H., & Lee, I. S. (2001). A Cytotoxic Secocycloartenoid from Abies koreana. Archives of pharmacal research, 24(6), 527-531. https://doi.org/10.1007/BF02975159