A Cytotoxic Secocycloartenoid from Abies koreana

Hyun Jung Kim, Quoc Khanh Le, Mi Hyun Lee, Tae Sung Kim, Hyeong Kyu Lee, Young Ho Kim, KiHwan Bae, Ik Soo Lee

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Two triterpenoids, 24-methylene-3,4-seco-cycloart-4(28)-en-3-oic acid (1) and 3-oxo-9β- lanosta-7,22Z,24-trien-26,23-olide (6) were isolated from Abies koreana, together with β- sitosterol (2), maltol (3), β-sitosterol-O-β-D-glucoside (4), and hexacosylferulate (5). The structures of the compounds were established based on the spectroscopic data. The cytotoxic activities of triterpenoids have been evaluated using the sulforhodamine B (SRB) method. Compound 1 showed moderate cytotoxicities against human lung carcinoma (A549), ovarian carcinoma (SK-OV-3), malignant melanoma (SK-MEL-2), and colon carcinoma (HCT-15) cell lines.

Original languageEnglish
Pages (from-to)527-531
Number of pages5
JournalArchives of Pharmacal Research
Volume24
Issue number6
Publication statusPublished - 2001 Dec 1
Externally publishedYes

Fingerprint

Abies
lissamine rhodamine B
Trientine
Carcinoma
Glucosides
Cytotoxicity
Cells
Acids
Melanoma
Colon
Cell Line
Lung
gamma-sitosterol
maltol

Keywords

  • 24-methylene-3,4-seco-cycloart-4(28)-en-3-oic acid
  • 3- Oxo-9β-lanosta-7,22z,24-trien-26,23-olide
  • Abies koreana
  • Cytotoxicity
  • Pinaceae

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Kim, H. J., Le, Q. K., Lee, M. H., Kim, T. S., Lee, H. K., Kim, Y. H., ... Lee, I. S. (2001). A Cytotoxic Secocycloartenoid from Abies koreana. Archives of Pharmacal Research, 24(6), 527-531.

A Cytotoxic Secocycloartenoid from Abies koreana. / Kim, Hyun Jung; Le, Quoc Khanh; Lee, Mi Hyun; Kim, Tae Sung; Lee, Hyeong Kyu; Kim, Young Ho; Bae, KiHwan; Lee, Ik Soo.

In: Archives of Pharmacal Research, Vol. 24, No. 6, 01.12.2001, p. 527-531.

Research output: Contribution to journalArticle

Kim, HJ, Le, QK, Lee, MH, Kim, TS, Lee, HK, Kim, YH, Bae, K & Lee, IS 2001, 'A Cytotoxic Secocycloartenoid from Abies koreana', Archives of Pharmacal Research, vol. 24, no. 6, pp. 527-531.
Kim HJ, Le QK, Lee MH, Kim TS, Lee HK, Kim YH et al. A Cytotoxic Secocycloartenoid from Abies koreana. Archives of Pharmacal Research. 2001 Dec 1;24(6):527-531.
Kim, Hyun Jung ; Le, Quoc Khanh ; Lee, Mi Hyun ; Kim, Tae Sung ; Lee, Hyeong Kyu ; Kim, Young Ho ; Bae, KiHwan ; Lee, Ik Soo. / A Cytotoxic Secocycloartenoid from Abies koreana. In: Archives of Pharmacal Research. 2001 ; Vol. 24, No. 6. pp. 527-531.
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